HitPredict

Interactor 1: H2AY (O75367)
Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (Histone H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205)
Gene: MACROH2A1

Interactor 2: MAX (P61244)
Protein max (Class D basic helix-loop-helix protein 4) (bHLHd4) (Myc-associated factor X)
Gene: MAX

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.51	1.00	0.715

Property	Details
Experiments	25609649
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HLH~Histone
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 369 Hs			1 160
+	Hs
		277500 H2AY_HUMAN (1-369): 6.52e-165: 467: 100.00		MYC_HUMAN (14-105): 1.82e-21: 91.5: 34.74
+	Hs
		277505 H2AY_HUMAN (1-369): 6.52e-165: 467: 100.00		MYCN_HUMAN (7-101): 2.1e-21: 91.1: 33.67
+	Hs
		373358 H2AW_HUMAN (1-368): 1.42e-145: 418: 66.04		MYC_HUMAN (14-105): 1.82e-21: 91.5: 34.74
+	Hs
		406748 H2AW_HUMAN (1-368): 1.42e-145: 418: 66.04		MYCN_HUMAN (7-101): 2.1e-21: 91.1: 33.67
+	Hs
		372492 H2A2B_HUMAN (1-125): 5.81e-65: 204: 64.06		MYC_HUMAN (14-105): 1.82e-21: 91.5: 34.74
+	Hs
		406357 H2A2B_HUMAN (1-125): 5.81e-65: 204: 64.06		MYCN_HUMAN (7-101): 2.1e-21: 91.1: 33.67
+	Hs
		370906 H2A1B_HUMAN (1-126): 1.28e-64: 203: 62.02		MYC_HUMAN (14-105): 1.82e-21: 91.5: 34.74
+	Hs
		371001 H2A1_HUMAN (1-126): 1.21e-64: 203: 62.02		MYC_HUMAN (14-105): 1.82e-21: 91.5: 34.74
+	Hs
		372159 H2A2C_HUMAN (1-125): 9.27e-64: 201: 63.28		MYC_HUMAN (14-105): 1.82e-21: 91.5: 34.74
+	Hs
		406233 H2A2C_HUMAN (1-125): 9.27e-64: 201: 63.28		MYCN_HUMAN (7-101): 2.1e-21: 91.1: 33.67