HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: H2AW (Q9P0M6)
Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2)
Gene: MACROH2A2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	29467282, 35013218
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HLH~Histone
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 372
+	Hs
		277500 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		H2AY_HUMAN (1-371): 8.22e-156: 444: 66.31
+	Hs
		277505 MYCN_HUMAN (12-451): 8.07e-58: 199: 33.40		H2AY_HUMAN (1-371): 8.22e-156: 444: 66.31
+	Hs
		406748 MYCN_HUMAN (12-451): 8.07e-58: 199: 33.40		H2AW_HUMAN (1-372): 5.29e-152: 434: 100.00
+	Hs
		372492 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		H2A2B_HUMAN (1-123): 1.25e-64: 203: 63.49
+	Hs
		370906 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		H2A1B_HUMAN (1-126): 6.68e-64: 201: 60.47
+	Hs
		371001 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		H2A1_HUMAN (1-126): 6.4e-64: 201: 60.47
+	Hs
		372159 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		H2A2C_HUMAN (1-126): 7.61e-64: 201: 61.24
+	Hs
		277623 MAX_HUMAN (354-454): 1.4e-24: 101: 32.67		H2AY_HUMAN (1-371): 8.22e-156: 444: 66.31
+	Hs
		406357 MYCN_HUMAN (12-451): 8.07e-58: 199: 33.40		H2A2B_HUMAN (1-123): 1.25e-64: 203: 63.49
+	Hs
		406233 MYCN_HUMAN (12-451): 8.07e-58: 199: 33.40		H2A2C_HUMAN (1-126): 7.61e-64: 201: 61.24