HitPredict

Interactor 1: PIAS1 (O75925)
E3 SUMO-protein ligase PIAS1 (EC 2.3.2.-) (DEAD/H box-binding protein 1) (E3 SUMO-protein transferase PIAS1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein)
Gene: PIAS1

Interactor 2: MBD1 (Q9UIS9)
Methyl-CpG-binding domain protein 1 (CXXC-type zinc finger protein 3) (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1)
Gene: MBD1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.639

Property	Details
Experiments	19074829, 17066076
Identification Methods	affinity chromatography technology, two hybrid, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0008270 - zinc ion binding GO:0016607 - nuclear speck
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 651 Hs			1 605
+	Hs
		1355892 PIAS3_HUMAN (1-651): 0: 740: 56.88		MBD1_HUMAN (1-605): 0: 886: 100.00
+	Hs
		278348 PIAS2_HUMAN (1-566): 0: 633: 58.97		MBD1_HUMAN (1-605): 0: 886: 100.00