HitPredict

Interactor 1: PIAS2 (O75928)
E3 SUMO-protein ligase PIAS2 (EC 2.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (E3 SUMO-protein transferase PIAS2) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)
Gene: PIAS2

Interactor 2: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	30415952, 17471507, 17418410
Identification Methods	proximity labelling technology, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 621 Hs			1 454
+	Hs
		278272 PIAS2_HUMAN (1-621): 0: 811: 100.00		SRBP2_HUMAN (124-446): 8.64e-35: 139: 12.54
+	Hs
		252893 PIAS2_HUMAN (1-621): 0: 811: 100.00		MITF_HUMAN (155-450): 1.47e-29: 123: 14.47
+	Hs
		278326 PIAS2_HUMAN (1-621): 0: 811: 100.00		MNT_HUMAN (274-452): 2.36e-24: 107: 21.11
+	Hs
		347309 PIAS4_HUMAN (2-499): 1.7e-172: 502: 43.32		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		1016123 PIAS3_HUMAN (1-621): 0: 666: 55.25		SRBP2_HUMAN (124-446): 8.64e-35: 139: 12.54
+	Mm
		222296 PIAS3_MOUSE (1-621): 0: 665: 55.25		MITF_MOUSE (155-450): 3.21e-31: 127: 15.11
+	Hs
		278069 PIAS1_HUMAN (1-621): 0: 653: 54.10		SRBP2_HUMAN (124-446): 8.64e-35: 139: 12.54
+	Hs
		252940 PIAS3_HUMAN (1-621): 0: 666: 55.25		MITF_HUMAN (155-450): 1.47e-29: 123: 14.47
+	Hs
		252892 PIAS1_HUMAN (1-621): 0: 653: 54.10		MITF_HUMAN (155-450): 1.47e-29: 123: 14.47
+	Hs
		1218681 PIAS4_HUMAN (2-499): 1.7e-172: 502: 43.32		MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71