HitPredict

Interactor 1: PIAS2 (O75928)
E3 SUMO-protein ligase PIAS2 (EC 2.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (E3 SUMO-protein transferase PIAS2) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)
Gene: PIAS2

Interactor 2: SRBP2 (Q12772)
Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2 (Transcription factor SREBF2)]
Gene: SREBF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	20936779
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 621 Hs			1 1141
+	Hs
		1016123 PIAS3_HUMAN (1-621): 0: 666: 55.25		SRBP2_HUMAN (1-1141): 0: 1168: 100.00
+	Hs
		278069 PIAS1_HUMAN (1-621): 0: 653: 54.10		SRBP2_HUMAN (1-1141): 0: 1168: 100.00
+	Hs
		252893 PIAS2_HUMAN (1-621): 0: 811: 100.00		MITF_HUMAN (55-441): 3.85e-34: 140: 17.04
+	Hs
		278313 PIAS2_HUMAN (1-621): 0: 811: 100.00		CBP_HUMAN (5-492): 1.07e-29: 130: 12.88
+	Mm
		222296 PIAS3_MOUSE (1-621): 0: 665: 55.25		MITF_MOUSE (55-441): 5.92e-35: 143: 17.29
+	Hs
		252940 PIAS3_HUMAN (1-621): 0: 666: 55.25		MITF_HUMAN (55-441): 3.85e-34: 140: 17.04
+	Hs
		1270855 PIAS3_HUMAN (1-621): 0: 666: 55.25		CBP_HUMAN (5-492): 1.07e-29: 130: 12.88
+	Hs
		252892 PIAS1_HUMAN (1-621): 0: 653: 54.10		MITF_HUMAN (55-441): 3.85e-34: 140: 17.04
+	Hs
		1167144 PIAS3_HUMAN (1-621): 0: 666: 55.25		MCAF1_HUMAN (17-480): 6.91e-28: 124: 12.42
+	Hs
		278139 PIAS1_HUMAN (1-621): 0: 653: 54.10		CBP_HUMAN (5-492): 1.07e-29: 130: 12.88
+	Hs
		999269 PIAS3_HUMAN (1-621): 0: 666: 55.25		EP300_HUMAN (13-430): 1.85e-13: 77.7: 8.50
+	Hs
		278068 PIAS1_HUMAN (1-621): 0: 653: 54.10		EP300_HUMAN (13-430): 1.85e-13: 77.7: 8.50
+	Hs
		1167108 PIAS4_HUMAN (2-499): 1.7e-172: 502: 43.32		MCAF1_HUMAN (17-480): 6.91e-28: 124: 12.42