HitPredict

Interactor 1: PIAS2 (O75928)
E3 SUMO-protein ligase PIAS2 (EC 2.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (E3 SUMO-protein transferase PIAS2) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)
Gene: PIAS2

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	11117529
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0008270 - zinc ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 621 Hs			1 530
+	Hs
		278206 PIAS2_HUMAN (1-621): 0: 811: 100.00		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		278207 PIAS2_HUMAN (1-621): 0: 811: 100.00		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		278228 PIAS2_HUMAN (1-621): 0: 811: 100.00		NR4A1_HUMAN (7-501): 3.18e-101: 318: 25.30
+	Hs
		1270069 PIAS3_HUMAN (1-621): 0: 666: 55.25		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		278138 PIAS1_HUMAN (1-621): 0: 653: 54.10		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		370843 PIAS3_HUMAN (1-621): 0: 666: 55.25		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		277875 PIAS1_HUMAN (1-621): 0: 653: 54.10		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		277974 PIAS1_HUMAN (1-621): 0: 653: 54.10		HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30
+	Hs
		611538 PIAS3_HUMAN (1-621): 0: 666: 55.25		NR4A1_HUMAN (7-501): 3.18e-101: 318: 25.30
+	Hs
		277876 PIAS1_HUMAN (1-621): 0: 653: 54.10		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		278072 PIAS1_HUMAN (1-621): 0: 653: 54.10		NR1H3_HUMAN (65-499): 1.77e-104: 322: 20.97
+	Hs
		278004 PIAS1_HUMAN (1-621): 0: 653: 54.10		NR1H2_HUMAN (49-499): 2.78e-103: 319: 20.86
+	Hs
		278210 PIAS2_HUMAN (1-621): 0: 811: 100.00		PRGR_HUMAN (149-459): 2.26e-41: 161: 32.82
+	Hs
		277936 PIAS1_HUMAN (1-621): 0: 653: 54.10		NR4A1_HUMAN (7-501): 3.18e-101: 318: 25.30
+	Hs
		278213 PIAS2_HUMAN (1-621): 0: 811: 100.00		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		414536 PIAS3_HUMAN (1-621): 0: 666: 55.25		PRGR_HUMAN (149-459): 2.26e-41: 161: 32.82
+	Hs
		487883 PIAS3_HUMAN (1-621): 0: 666: 55.25		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		277885 PIAS1_HUMAN (1-621): 0: 653: 54.10		PRGR_HUMAN (149-459): 2.26e-41: 161: 32.82
+	Hs
		277899 PIAS1_HUMAN (1-621): 0: 653: 54.10		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		487590 PIAS4_HUMAN (2-499): 1.7e-172: 502: 43.32		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59