Protein: ZBT16
Zinc finger and BTB domain-containing protein 16 (Promyelocytic leukemia zinc finger protein) (Zinc finger protein 145) (Zinc finger protein PLZF)

Gene: ZBT16, ZBTB16
Organism: Homo sapiens
Interactions: 178
UniProt ID: Q05516

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001222 - transcription corepressor binding
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1051356

ZBT16
Zinc finger and BTB domain-containing protein 16

11

14

Small-scale

0.978

High

74335

ZBT42
Zinc finger and BTB domain-containing protein 42

2

19

High-throughput

0.783

High

1051384

ZN620
Zinc finger protein 620

2

15

High-throughput

0.783

High

1051392

ZN655
Zinc finger protein 655

2

14

High-throughput

0.783

High

1051394

IKBD
NF-kappa-B inhibitor delta

2

2

High-throughput

0.783

High

1051424

ZN552
Zinc finger protein 552

2

17

High-throughput

0.783

High

1051367

HDAC1
Histone deacetylase 1

12

9

Small-scale

0.758

High

1051445

NCOR2
Nuclear receptor corepressor 2

7

3

Small-scale

0.746

High

278312

NCOR1
Nuclear receptor corepressor 1

5

5

Small-scale

0.716

High

1051441

ZBT32
Zinc finger and BTB domain-containing protein 32

1

17

Small-scale

0.713

High

1051408

CRBN
Protein cereblon

1

0

Small-scale

0.708

High

1051381

K1C40
Keratin, type I cytoskeletal 40

4

9

High-throughput

0.705

High

1051407

SIN3A
Paired amphipathic helix protein Sin3a

4

1

Small-scale

0.699

High

227512

SPOP
Speckle-type POZ protein

1

1

High-throughput

0.698

High

600287

ZNF24
Zinc finger protein 24

1

20

High-throughput

0.698

High

219158

LTOR5
Ragulator complex protein LAMTOR5

5

0

High-throughput

0.695

High

832695

BCL6
B-cell lymphoma 6 protein

1

17

Small-scale

0.680

High

1051416

TRI54
Tripartite motif-containing protein 54

3

20

High-throughput

0.675

High

1051365

TRAF1
TNF receptor-associated factor 1

3

9

High-throughput

0.671

High

940927

HDAC4
Histone deacetylase 4

3

11

Small-scale

0.667

High

343749

LDOC1
Protein LDOC1

3

3

High-throughput

0.667

High

1051364

TRAF2
TNF receptor-associated factor 2

3

20

High-throughput

0.667

High

1051393

CEP70
Centrosomal protein of 70 kDa

3

6

High-throughput

0.667

High

1051410

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

0

High-throughput

0.663

High

549129

CDK4
Cyclin-dependent kinase 4

1

1

High-throughput

0.656

High

765430

BMI1
Polycomb complex protein BMI-1

2

10

Small-scale

0.646

High

1051360

GOGA2
Golgin subfamily A member 2

4

12

High-throughput

0.646

High

993515

UBC9
SUMO-conjugating enzyme UBC9

3

2

Small-scale

0.645

High

571938

TRI27
Zinc finger protein RFP

2

20

High-throughput

0.640

High

714054

PML
Protein PML

2

20

Small-scale

0.639

High

1051427

VTA1
Vacuolar protein sorting-associated protein VTA1 homolog

3

0

High-throughput

0.639

High

1051437

HDAC5
Histone deacetylase 5

2

10

Small-scale

0.629

High

1051398

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

0

Small-scale

0.628

High

543496

VDR
Vitamin D3 receptor

2

4

Small-scale

0.624

High

1051361

EP300
Histone acetyltransferase p300

2

7

Small-scale

0.624

High

1051440

ZN281
Zinc finger protein 281

1

14

High-throughput

0.621

High

1034985

KPCE
Protein kinase C epsilon type

1

1

Small-scale

0.618

High

1051368

CUL3
Cullin-3

1

20

Small-scale

0.618

High

210260

PHF1
PHD finger protein 1

2

1

High-throughput

0.606

High

269179

HSF2B
Heat shock factor 2-binding protein

2

2

High-throughput

0.606

High

623297

RO52
E3 ubiquitin-protein ligase TRIM21

2

20

High-throughput

0.606

High

725374

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

2

2

High-throughput

0.606

High

783244

TRI23
E3 ubiquitin-protein ligase TRIM23

2

1

High-throughput

0.606

High

885225

HXA1
Homeobox protein Hox-A1

2

10

High-throughput

0.606

High

1025214

HXC5
Homeobox protein Hox-C5

2

11

High-throughput

0.606

High

1051359

TLE5
TLE family member 5

2

2

High-throughput

0.606

High

1051377

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

9

High-throughput

0.606

High

1051379

FHL5
Four and a half LIM domains protein 5

2

9

High-throughput

0.606

High

1051396

CCHCR
Coiled-coil alpha-helical rod protein 1

2

2

High-throughput

0.606

High

1051413

TRAF4
TNF receptor-associated factor 4

2

19

High-throughput

0.606

High

1051418

CTDS1
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

2

13

High-throughput

0.606

High

1051420

CARD9
Caspase recruitment domain-containing protein 9

2

6

High-throughput

0.606

High

1051435

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

20

High-throughput

0.606

High

1051357

MTG8
Protein CBFA2T1

2

0

Small-scale

0.605

High

843503

HD
Huntingtin

2

5

High-throughput

0.596

High

188250

HDAC3
Histone deacetylase 3

2

8

Small-scale

0.595

High

464926

SP1
Transcription factor Sp1

1

11

High-throughput

0.590

High

519973

ANDR
Androgen receptor

2

18

Small-scale

0.586

High

443325

CDK1
Cyclin-dependent kinase 1

1

0

Small-scale

0.586

High

996116

EF1A1
Elongation factor 1-alpha 1

1

1

Small-scale

0.586

High

1051374

EZH2
Histone-lysine N-methyltransferase EZH2

2

5

Small-scale

0.584

High

297795

PIAS2
E3 SUMO-protein ligase PIAS2

2

0

High-throughput

0.580

High

1048828

REL
Proto-oncogene c-Rel

2

0

High-throughput

0.580

High

1051383

RINT1
RAD50-interacting protein 1

2

0

High-throughput

0.580

High

1051401

MYLIP
E3 ubiquitin-protein ligase MYLIP

2

0

High-throughput

0.580

High

1051406

RAB3I
Rab-3A-interacting protein

2

0

High-throughput

0.580

High

1051421

GO45
Golgin-45

2

0

High-throughput

0.580

High

1051423

OSBL3
Oxysterol-binding protein-related protein 3

2

0

High-throughput

0.580

High

1051429

F217B
Protein FAM217B

2

0

High-throughput

0.580

High

1051438

AMOL2
Angiomotin-like protein 2

2

0

High-throughput

0.580

High

274313

SIN3B
Paired amphipathic helix protein Sin3b

1

1

Small-scale

0.573

High

1051370

FHL2
Four and a half LIM domains protein 2

1

9

Small-scale

0.573

High

1051425

SH24A
SH2 domain-containing protein 4A

1

1

High-throughput

0.573

High

991302

SUMO1
Small ubiquitin-related modifier 1

2

0

Small-scale

0.569

High

662409

GATA2
Endothelial transcription factor GATA-2

1

1

Small-scale

0.561

High

886786

CEBPA
CCAAT/enhancer-binding protein alpha

1

6

Small-scale

0.561

High

1051434

HDAC6
Protein deacetylase HDAC6

1

11

Small-scale

0.561

High

65033

GG6L9
Golgin subfamily A member 6-like protein 9

2

12

High-throughput

0.553

High

143831

NDKM
Nucleoside diphosphate kinase, mitochondrial

2

1

High-throughput

0.553

High

350448

GPAN1
G patch domain and ankyrin repeat-containing protein 1

2

2

High-throughput

0.553

High

1051414

KIFC3
Kinesin-like protein KIFC3

2

4

High-throughput

0.553

High

1051432

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

0

High-throughput

0.549

High

180510

PLS1
Phospholipid scramblase 1

1

1

High-throughput

0.541

High

848858

MAGAB
Melanoma-associated antigen 11

1

3

High-throughput

0.541

High

1051373

CC85B
Coiled-coil domain-containing protein 85B

1

1

High-throughput

0.541

High

1051411

KR412
Keratin-associated protein 4-12

1

20

High-throughput

0.541

High

1051431

LYAR
Cell growth-regulating nucleolar protein

1

1

High-throughput

0.541

High

1051433

CEP72
Centrosomal protein of 72 kDa

1

1

High-throughput

0.541

High

442681

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.537

High

370010

TIMP1
Metalloproteinase inhibitor 1

1

0

Small-scale

0.529

High

663754

IL32
Interleukin-32

1

0

Small-scale

0.529

High

1051387

LYRIC
Protein LYRIC

1

0

Small-scale

0.529

High

520564

RARA
Retinoic acid receptor alpha

1

10

Small-scale

0.527

High

127937

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

0

High-throughput

0.518

High

155658

FCHO1
F-BAR domain only protein 1

1

0

High-throughput

0.518

High

251340

CIDEA
Lipid transferase CIDEA

1

0

High-throughput

0.518

High

255614

DPM1
Dolichol-phosphate mannosyltransferase subunit 1

1

0

High-throughput

0.518

High

627641

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

0

High-throughput

0.518

High

787991

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.518

High

902263

RB27A
Ras-related protein Rab-27A

1

0

High-throughput

0.518

High

928426

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.518

High

948798

CD81
CD81 antigen

1

0

High-throughput

0.518

High

1040471

GSTM4
Glutathione S-transferase Mu 4

1

0

High-throughput

0.518

High

1051366

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

0

High-throughput

0.518

High

1051369

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.518

High

1051372

PA1B3
Platelet-activating factor acetylhydrolase IB subunit alpha1

1

0

High-throughput

0.518

High

1051386

HDX
Highly divergent homeobox

1

0

High-throughput

0.518

High

1051388

DAAF5
Dynein axonemal assembly factor 5

1

0

High-throughput

0.518

High

1051415

TGT
Queuine tRNA-ribosyltransferase catalytic subunit 1

1

0

High-throughput

0.518

High

1051417

WDR33
pre-mRNA 3' end processing protein WDR33

1

0

High-throughput

0.518

High

1051419

TOLIP
Toll-interacting protein

1

0

High-throughput

0.518

High

1051430

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

0

High-throughput

0.518

High

1051436

APC5
Anaphase-promoting complex subunit 5

1

0

High-throughput

0.518

High

1051443

LSM2
U6 snRNA-associated Sm-like protein LSm2

1

0

High-throughput

0.518

High

1051382

Q6FHY5
MEOX2 protein

1

11

High-throughput

0.515

High

221118

SPY2
Protein sprouty homolog 2

1

8

High-throughput

0.508

High

405440

KITH
Thymidine kinase, cytosolic

1

1

High-throughput

0.508

High

627956

ANXA7
Annexin A7

1

2

High-throughput

0.508

High

808031

CDN1A
Cyclin-dependent kinase inhibitor 1

1

2

High-throughput

0.508

High

896734

DYN2
Dynamin-2

1

2

High-throughput

0.508

High

1014481

SMAD3
Mothers against decapentaplegic homolog 3

1

4

High-throughput

0.508

High

1051371

GRB7
Growth factor receptor-bound protein 7

1

2

High-throughput

0.508

High

1051375

SMN
Survival motor neuron protein

1

1

High-throughput

0.508

High

395969

ESR1
Estrogen receptor

1

18

Small-scale

0.501

High

403999

GCR
Glucocorticoid receptor

1

18

Small-scale

0.501

High

840043

CASP3
Caspase-3

1

1

Small-scale

0.501

High

893003

AGTR2
Type-2 angiotensin II receptor

1

1

Small-scale

0.501

High

1051397

HDAC7
Histone deacetylase 7

1

10

Small-scale

0.501

High

1051402

HDAC2
Histone deacetylase 2

1

9

Small-scale

0.501

High

569243

YJU2B
Probable splicing factor YJU2B

1

6

High-throughput

0.494

High

1051395

ENOX1
Ecto-NOX disulfide-thiol exchanger 1

1

1

High-throughput

0.494

High

1051405

LMTK3
Serine/threonine-protein kinase LMTK3

1

3

High-throughput

0.494

High

1051442

COQ6
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

1

1

High-throughput

0.494

High

633371

MX1
Interferon-induced GTP-binding protein Mx1

1

2

Small-scale

0.481

High

893833

MEOX2
Homeobox protein MOX-2

1

10

High-throughput

0.481

High

1051400

PIBF1
Progesterone-induced-blocking factor 1

1

6

High-throughput

0.481

High

487223

PARP1
Poly [ADP-ribose] polymerase 1

1

0

Small-scale

0.480

High

316819

MTA2
Metastasis-associated protein MTA2

1

1

Small-scale

0.479

High

413680

P53
Cellular tumor antigen p53

1

6

Small-scale

0.479

High

488115

IFIT2
Interferon-induced protein with tetratricopeptide repeats 2

1

2

Small-scale

0.479

High

590410

GATA1
Erythroid transcription factor

1

1

Small-scale

0.479

High

730530

1433S
14-3-3 protein sigma

1

12

High-throughput

0.479

High

853230

CBX5
Chromobox protein homolog 5

1

20

Small-scale

0.479

High

971431

1433E
14-3-3 protein epsilon

1

1

High-throughput

0.479

High

1051358

ACK1
Activated CDC42 kinase 1

1

5

Small-scale

0.479

High

1051363

NFIA
Nuclear factor 1 A-type

1

12

High-throughput

0.479

High

1051376

Q4G0R1
PIBF1 protein

1

6

High-throughput

0.470

High

1051385

Q7KZS0
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.470

High

69373

WASH1
WASH complex subunit 1

1

0

High-throughput

0.460

High

273757

ATS4
A disintegrin and metalloproteinase with thrombospondin motifs 4

1

0

High-throughput

0.460

High

352116

MBD3
Methyl-CpG-binding domain protein 3

1

0

Small-scale

0.458

High

1051422

TXNIP
Thioredoxin-interacting protein

1

0

Small-scale

0.458

High

482606

GNAO
Guanine nucleotide-binding protein G(o) subunit alpha

1

1

Small-scale

0.457

High

663522

FSHR
Follicle-stimulating hormone receptor

1

1

Small-scale

0.439

High

426982

IL6
Interleukin-6

1

0

High-throughput

0.438

High

567209

PPA5
Tartrate-resistant acid phosphatase type 5

1

0

High-throughput

0.438

High

1051428

PNRC2
Proline-rich nuclear receptor coactivator 2

1

0

High-throughput

0.438

High

1051362

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

1

Small-scale

0.437

High

1051444

KLK4
Kallikrein-4

1

1

Small-scale

0.437

High

748797

ICAM3
Intercellular adhesion molecule 3

1

1

High-throughput

0.417

High

1051426

K1549
UPF0606 protein KIAA1549

1

2

High-throughput

0.417

High

1051439

COG6
Conserved oligomeric Golgi complex subunit 6

3

0

High-throughput

0.350

High

1051412

PHAF1
Phagosome assembly factor 1

3

0

High-throughput

0.347

High

1051409

HBEGF
Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor

2

0

Small-scale

0.332

High

1051378

EFHC2
EF-hand domain-containing family member C2

2

0

High-throughput

0.316

High

1051380

TTC23
Tetratricopeptide repeat protein 23

2

0

High-throughput

0.316

High

1051389

F90A1
Protein FAM90A1

2

0

High-throughput

0.316

High

775758

ATP7B
Copper-transporting ATPase 2

1

0

Small-scale

0.299

High

292618

RENR
Renin receptor

1

0

Small-scale

0.288

High

658546

GCSH
Glycine cleavage system H protein, mitochondrial

1

0

High-throughput

0.282

High

1051390

THNS2
Threonine synthase-like 2

1

0

High-throughput

0.282

High

1051391

RFLB
Refilin-B

1

0

High-throughput

0.282

High

1051403

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

0

High-throughput

0.282

High

458909

HEXB
Beta-hexosaminidase subunit beta

1

0

High-throughput

0.268

Low

1051404

LRIG1
Leucine-rich repeats and immunoglobulin-like domains protein 1

1

0

Small-scale

0.265

Low

472299

CFAH
Complement factor H

1

0

High-throughput

0.251

Low

1051399

RSAD2
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025