HitPredict

Interactor 1: NEBL (O76041)
Nebulette (Actin-binding Z-disk protein)
Gene: NEBL

Interactor 2: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.50	0.470

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1014 Hs			1 664
+	Hs
		282302 NEBL_HUMAN (1-1014): 0: 665: 100.00		GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43
+	Hs
		282299 NEBL_HUMAN (1-1014): 0: 665: 100.00		NFL_HUMAN (28-433): 1.96e-26: 115: 27.07
+	Hs
		117889 MYO1F_HUMAN (461-1013): 2.75e-53: 205: 11.02		LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37
+	Hs
		595217 SPTN1_HUMAN (359-1013): 4.51e-39: 160: 11.50		LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37
+	Hs
		359934 SRC8_HUMAN (284-641): 3.71e-12: 72.1: 14.37		LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00
+	Hs
		443504 SPTN1_HUMAN (359-1013): 4.51e-39: 160: 11.50		VIME_HUMAN (27-389): 3.94e-31: 129: 28.93
+	Hs
		569077 SPTN1_HUMAN (359-1013): 4.51e-39: 160: 11.50		DESM_HUMAN (27-389): 6.1e-28: 119: 30.03
+	Hs
		422175 SPTN1_HUMAN (359-1013): 4.51e-39: 160: 11.50		NFL_HUMAN (28-433): 1.96e-26: 115: 27.07
+	Hs
		443759 SH3G3_HUMAN (811-1013): 2.44e-31: 128: 16.59		VIME_HUMAN (27-389): 3.94e-31: 129: 28.93
+	Hs
		443758 SH3G1_HUMAN (808-1013): 1.7e-29: 123: 15.02		VIME_HUMAN (27-389): 3.94e-31: 129: 28.93
+	Hs
		275169 GRAP2_HUMAN (775-1013): 6.92e-30: 123: 13.22		GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43
+	Hs
		443328 NEBU_HUMAN (281-878): 2.26e-21: 103: 20.16		VIME_HUMAN (27-389): 3.94e-31: 129: 28.93
+	Hs
		569047 NEBU_HUMAN (281-878): 2.26e-21: 103: 20.16		DESM_HUMAN (27-389): 6.1e-28: 119: 30.03
+	Hs
		443521 LASP1_HUMAN (496-672): 7.48e-19: 89.4: 25.14		VIME_HUMAN (27-389): 3.94e-31: 129: 28.93
+	Hs
		535403 ITSN1_HUMAN (364-1012): 1.76e-19: 96.9: 11.30		GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43
+	Hs
		569085 ITSN1_HUMAN (364-1012): 1.76e-19: 96.9: 11.30		DESM_HUMAN (27-389): 6.1e-28: 119: 30.03
+	Hs
		422187 ITSN1_HUMAN (364-1012): 1.76e-19: 96.9: 11.30		NFL_HUMAN (28-433): 1.96e-26: 115: 27.07
+	Hs
		535397 LASP1_HUMAN (496-672): 7.48e-19: 89.4: 25.14		GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43
+	Hs
		422179 LASP1_HUMAN (496-672): 7.48e-19: 89.4: 25.14		NFL_HUMAN (28-433): 1.96e-26: 115: 27.07
+	Hs
		443514 SRC8_HUMAN (284-641): 3.71e-12: 72.1: 14.37		VIME_HUMAN (27-389): 3.94e-31: 129: 28.93