Protein: SAP30
Histone deacetylase complex subunit SAP30 (30 kDa Sin3-associated polypeptide) (Sin3 corepressor complex subunit SAP30) (Sin3-associated polypeptide p30)

Gene: SAP30
Organism: Homo sapiens
Interactions: 137
UniProt ID: O75446

Gene Ontology (top 5):
GO:0000118 - histone deacetylase complex
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003677 - DNA binding
GO:0003712 - transcription coregulator activity
GO:0003714 - transcription corepressor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

282295

SIN3A
Paired amphipathic helix protein Sin3a

16

4

Small-scale

0.986

High

282266

BRM1L
Breast cancer metastasis-suppressor 1-like protein

4

3

Small-scale

0.895

High

274269

SIN3B
Paired amphipathic helix protein Sin3b

4

4

Small-scale

0.892

High

282310

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

3

3

High-throughput

0.861

High

282313

BRMS1
Breast cancer metastasis-suppressor 1

3

3

Small-scale

0.847

High

282250

HDAC1
Histone deacetylase 1

19

7

Small-scale

0.765

High

282284

HDAC2
Histone deacetylase 2

13

7

Small-scale

0.759

High

282260

RBBP7
Histone-binding protein RBBP7

11

4

Small-scale

0.757

High

282242

RBBP4
Histone-binding protein RBBP4

10

4

Small-scale

0.756

High

282326

ING1
Inhibitor of growth protein 1

5

7

Small-scale

0.721

High

282315

SHCAF
SIN3-HDAC complex-associated factor

5

1

Small-scale

0.716

High

282236

FOXK2
Forkhead box protein K2

4

2

Small-scale

0.704

High

282222

ARI4A
AT-rich interactive domain-containing protein 4A

4

1

Small-scale

0.703

High

282306

ING2
Inhibitor of growth protein 2

4

6

Small-scale

0.699

High

282233

FOXK1
Forkhead box protein K1

3

2

High-throughput

0.675

High

282263

ARI4B
AT-rich interactive domain-containing protein 4B

3

1

High-throughput

0.667

High

282268

ZN704
Zinc finger protein 704

3

2

High-throughput

0.662

High

282305

SP130
Histone deacetylase complex subunit SAP130

3

3

High-throughput

0.656

High

190103

TNC18
Trinucleotide repeat-containing gene 18 protein

2

1

High-throughput

0.628

High

282300

PHF23
PHD finger protein 23

2

0

High-throughput

0.602

High

278188

NCOR1
Nuclear receptor corepressor 1

2

4

Small-scale

0.585

High

210224

PHF1
PHD finger protein 1

2

1

Small-scale

0.584

High

282254

CHD4
Chromodomain-helicase-DNA-binding protein 4

2

4

Small-scale

0.584

High

282258

EZH2
Histone-lysine N-methyltransferase EZH2

2

2

High-throughput

0.584

High

282281

GATD1
GATA zinc finger domain-containing protein 1

2

1

High-throughput

0.584

High

282293

PHF12
PHD finger protein 12

2

5

Small-scale

0.584

High

96985

E9PJF5
BRMS1 transcriptional repressor and anoikis regulator

1

3

High-throughput

0.575

High

282301

MAD3
Max dimerization protein 3

2

5

High-throughput

0.574

High

282321

BAHC1
BAH and coiled-coil domain-containing protein 1

2

1

High-throughput

0.574

High

282210

MTA2
Metastasis-associated protein MTA2

2

2

Small-scale

0.571

High

282296

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

3

Small-scale

0.561

High

282311

ZN395
Zinc finger protein 395

1

2

Small-scale

0.561

High

282251

CUL4B
Cullin-4B

2

0

Small-scale

0.559

High

282219

TYY1
Transcriptional repressor protein YY1

1

0

Small-scale

0.549

High

282318

SAMN1
SAM domain-containing protein SAMSN-1

1

0

Small-scale

0.537

High

282218

CSK22
Casein kinase II subunit alpha'

1

1

High-throughput

0.536

High

282228

MAX
Protein max

1

3

High-throughput

0.536

High

282232

CSK21
Casein kinase II subunit alpha

1

1

High-throughput

0.536

High

282252

FHL2
Four and a half LIM domains protein 2

1

1

High-throughput

0.536

High

282271

TF2LX
Homeobox protein TGIF2LX

1

3

High-throughput

0.536

High

282304

TGIF2
Homeobox protein TGIF2

1

3

High-throughput

0.536

High

282312

SP30L
Histone deacetylase complex subunit SAP30L

1

1

High-throughput

0.536

High

282332

NCOR2
Nuclear receptor corepressor 2

1

2

Small-scale

0.536

High

282230

PHS
Pterin-4-alpha-carbinolamine dehydratase

1

0

High-throughput

0.518

High

282238

ID3
DNA-binding protein inhibitor ID-3

1

0

High-throughput

0.518

High

184034

CLIC2
Chloride intracellular channel protein 2

1

0

High-throughput

0.513

High

282215

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.513

High

282216

H2AZ
Histone H2A.Z

1

0

High-throughput

0.513

High

282229

RL15
Large ribosomal subunit protein eL15

1

0

High-throughput

0.513

High

282235

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

High-throughput

0.513

High

282253

SMC1A
Structural maintenance of chromosomes protein 1A

1

0

High-throughput

0.513

High

282261

DECR
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial

1

0

High-throughput

0.513

High

282289

ADAT3
Probable inactive tRNA-specific adenosine deaminase-like protein 3

1

0

High-throughput

0.513

High

282298

BCL7B
B-cell CLL/lymphoma 7 protein family member B

1

0

High-throughput

0.513

High

282314

SRA1
Steroid receptor RNA activator 1

1

0

High-throughput

0.513

High

282316

ZCC17
Zinc finger CCHC domain-containing protein 17

1

0

High-throughput

0.513

High

282317

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.513

High

282320

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

0

High-throughput

0.513

High

282328

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.513

High

282241

MAD1
Max dimerization protein 1

1

5

Small-scale

0.501

High

282309

RPF2
Ribosome production factor 2 homolog

1

0

High-throughput

0.493

High

282211

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.493

High

282223

SYUA
Alpha-synuclein

1

0

High-throughput

0.493

High

282225

HD
Huntingtin

1

0

High-throughput

0.493

High

282234

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.493

High

282237

NC2B
Protein Dr1

1

0

High-throughput

0.493

High

282274

PIAS4
E3 SUMO-protein ligase PIAS4

1

0

High-throughput

0.493

High

282283

NDRG1
Protein NDRG1

1

0

High-throughput

0.493

High

282286

APBB2
Amyloid beta precursor protein binding family B member 2

1

0

High-throughput

0.493

High

282331

TF3C3
General transcription factor 3C polypeptide 3

1

0

High-throughput

0.493

High

282269

CIR1
Corepressor interacting with RBPJ 1

1

0

Small-scale

0.486

High

282262

H2B2E
Histone H2B type 2-E

1

0

Small-scale

0.480

High

188131

HDAC3
Histone deacetylase 3

1

7

Small-scale

0.479

High

243485

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

5

High-throughput

0.479

High

248260

HBP1
HMG box-containing protein 1

1

3

High-throughput

0.479

High

259211

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

282212

MBD3
Methyl-CpG-binding domain protein 3

1

2

High-throughput

0.479

High

282213

MYCN
N-myc proto-oncogene protein

1

5

High-throughput

0.479

High

282221

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

1

5

High-throughput

0.479

High

282227

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

5

Small-scale

0.479

High

282231

H4
Histone H4

1

1

High-throughput

0.479

High

282239

KMT2A
Histone-lysine N-methyltransferase 2A

1

2

Small-scale

0.479

High

282243

BPTF
Nucleosome-remodeling factor subunit BPTF

1

2

High-throughput

0.479

High

282244

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

4

High-throughput

0.479

High

282247

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

282248

MTA1
Metastasis-associated protein MTA1

1

2

High-throughput

0.479

High

282255

SHPRH
E3 ubiquitin-protein ligase SHPRH

1

6

High-throughput

0.479

High

282270

P66A
Transcriptional repressor p66-alpha

1

1

High-throughput

0.479

High

282276

CHD5
Chromodomain-helicase-DNA-binding protein 5

1

4

High-throughput

0.479

High

282280

ZN296
Zinc finger protein 296

1

2

High-throughput

0.479

High

282282

P66B
Transcriptional repressor p66-beta

1

1

High-throughput

0.479

High

282285

EZH1
Histone-lysine N-methyltransferase EZH1

1

2

High-throughput

0.479

High

282294

CIC
Protein capicua homolog

1

2

High-throughput

0.479

High

282299

MTA3
Metastasis-associated protein MTA3

1

5

High-throughput

0.479

High

282303

BC11B
B-cell lymphoma/leukemia 11B

1

2

High-throughput

0.479

High

282307

BC11A
BCL11 transcription factor A

1

2

High-throughput

0.479

High

282323

MBD2
Methyl-CpG-binding domain protein 2

1

2

High-throughput

0.479

High

282325

HMGX4
HMG domain-containing protein 4

1

2

High-throughput

0.479

High

282327

BRPF3
Bromodomain and PHD finger-containing protein 3

1

1

High-throughput

0.479

High

282330

MTF2
Metal-response element-binding transcription factor 2

1

1

High-throughput

0.479

High

282220

ELAV4
ELAV-like protein 4

1

1

High-throughput

0.470

High

282224

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.460

High

155267

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

0

High-throughput

0.458

High

168159

HAT1
Histone acetyltransferase type B catalytic subunit

1

0

High-throughput

0.458

High

282209

EED
Polycomb protein EED

1

0

High-throughput

0.458

High

282214

RET1
Retinol-binding protein 1

1

0

Small-scale

0.458

High

282217

MYBB
Myb-related protein B

1

0

High-throughput

0.458

High

282226

TAF6
Transcription initiation factor TFIID subunit 6

1

0

Small-scale

0.458

High

282240

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

282245

CAF1A
Chromatin assembly factor 1 subunit A

1

0

High-throughput

0.458

High

282246

CAF1B
Chromatin assembly factor 1 subunit B

1

0

High-throughput

0.458

High

282249

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.458

High

282256

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

282259

DDB1
DNA damage-binding protein 1

1

0

Small-scale

0.458

High

282264

LIN52
Protein lin-52 homolog

1

0

High-throughput

0.458

High

282267

LIN9
Protein lin-9 homolog

1

0

High-throughput

0.458

High

282273

BAP18
BPTF-associated chromatin complex component 1

1

0

High-throughput

0.458

High

282275

HJURP
Holliday junction recognition protein

1

0

High-throughput

0.458

High

282277

SAP25
Histone deacetylase complex subunit SAP25

1

0

Small-scale

0.458

High

282278

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

0

Small-scale

0.458

High

282288

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

0

Small-scale

0.458

High

282290

LIN37
Protein lin-37 homolog

1

0

High-throughput

0.458

High

282291

Z512B
Zinc finger protein 512B

1

0

High-throughput

0.458

High

282292

PWP2A
PWWP domain-containing protein 2A

1

0

High-throughput

0.458

High

282302

DPY30
Protein dpy-30 homolog

1

0

High-throughput

0.458

High

282322

ZN219
Zinc finger protein 219

1

0

High-throughput

0.458

High

116432

H7BXF5
Sin3A associated protein 130

1

1

High-throughput

0.445

High

282329

TRI33
E3 ubiquitin-protein ligase TRIM33

1

1

Small-scale

0.445

High

282272

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

Small-scale

0.438

High

282257

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

1

0

High-throughput

0.279

Low

282265

ACTBL
Beta-actin-like protein 2

1

0

High-throughput

0.279

Low

282279

CO040
UPF0235 protein C15orf40

1

0

High-throughput

0.279

Low

282287

CMBL
Carboxymethylenebutenolidase homolog

1

0

High-throughput

0.279

Low

282297

LYST
Lysosomal-trafficking regulator

1

0

High-throughput

0.279

Low

282324

DKK2
Dickkopf-related protein 2

1

0

High-throughput

0.279

Low

282308

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

282319

RM22
Large ribosomal subunit protein uL22m

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025