HitPredict

Interactor 1: RNF8 (O76064)
E3 ubiquitin-protein ligase RNF8 (hRNF8) (EC 2.3.2.27) (RING finger protein 8) (RING-type E3 ubiquitin transferase RNF8)
Gene: RNF8

Interactor 2: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35831895
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0035861 - site of double-strand break
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 485 Hs			1 664
+	Hs
		282510 RNF8_HUMAN (1-485): 0: 523: 100.00		K2C5_HUMAN (24-390): 2.24e-117: 364: 25.95
+	Hs
		282457 RNF8_HUMAN (1-485): 0: 523: 100.00		K2C6A_HUMAN (23-407): 5.26e-116: 360: 23.71
+	Hs
		282465 RNF8_HUMAN (1-485): 0: 523: 100.00		K2C6B_HUMAN (24-407): 5.03e-115: 357: 23.51
+	Hs
		380469 TRI26_HUMAN (391-482): 8.35e-23: 103: 26.32		K2C6B_HUMAN (24-407): 5.03e-115: 357: 23.51
+	Hs
		443720 CHFR_HUMAN (37-474): 4.38e-82: 269: 16.59		VIME_HUMAN (27-389): 3.94e-31: 129: 28.93
+	Hs
		359651 RO52_HUMAN (389-483): 7.64e-26: 112: 31.25		LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00
+	Hs
		62675 TRI64_HUMAN (389-477): 3.17e-25: 109: 33.70		LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00
+	Hs
		360442 TRI39_HUMAN (394-483): 7.45e-24: 106: 29.03		LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00
+	Hs
		359894 TRI26_HUMAN (391-482): 8.35e-23: 103: 26.32		LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00
+	Hs
		360383 TRIM6_HUMAN (389-468): 4.88e-23: 103: 24.14		LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00
+	Hs
		584872 RO52_HUMAN (389-483): 7.64e-26: 112: 31.25		LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37
+	Hs
		595372 UHRF1_HUMAN (206-472): 3.2e-24: 108: 11.96		LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37
+	Hs
		536792 TRI27_HUMAN (392-478): 1.06e-22: 103: 21.11		LMNB2_HUMAN (21-580): 7.45e-51: 188: 52.68
+	Hs
		318813 LONF1_HUMAN (243-483): 1.28e-27: 118: 19.26		K2C75_HUMAN (23-390): 1.2e-45: 172: 23.85
+	Hs
		1089362 LONF1_HUMAN (243-483): 1.28e-27: 118: 19.26		KRT35_HUMAN (30-387): 1.7e-41: 158: 24.58
+	Hs
		318774 TRI27_HUMAN (392-478): 1.06e-22: 103: 21.11		K2C75_HUMAN (23-390): 1.2e-45: 172: 23.85
+	Hs
		535408 LONF2_HUMAN (185-483): 1.04e-29: 125: 14.29		GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43
+	Hs
		443320 RO52_HUMAN (389-483): 7.64e-26: 112: 31.25		VIME_HUMAN (27-389): 3.94e-31: 129: 28.93
+	Hs
		443583 TRI68_HUMAN (393-483): 4.57e-23: 103: 19.39		VIME_HUMAN (27-389): 3.94e-31: 129: 28.93
+	Hs
		535315 TRI27_HUMAN (392-478): 1.06e-22: 103: 21.11		GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43