HitPredict

Interactor 1: MED6 (O75586)
Mediator of RNA polymerase II transcription subunit 6 (Activator-recruited cofactor 33 kDa component) (ARC33) (Mediator complex subunit 6) (hMed6) (Renal carcinoma antigen NY-REN-28)
Gene: MED6

Interactor 2: NFIC (P08651)
Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein)
Gene: NFIC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	39617063
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 246 Hs			1 508
+	Hs
		287788 MED6_HUMAN (1-246): 1.59e-147: 413: 100.00		NFIX_HUMAN (2-507): 2.18e-156: 456: 56.73
+	Hs
		287783 MED6_HUMAN (1-246): 1.59e-147: 413: 100.00		NFIA_HUMAN (2-508): 1.69e-133: 398: 59.20
+	Hs
		142761 MED6_HUMAN (1-246): 1.59e-147: 413: 100.00		NFIB_HUMAN (1-423): 2.41e-128: 381: 63.47
+	Hs
		287768 MED6_HUMAN (1-246): 1.59e-147: 413: 100.00		SRBP1_HUMAN (293-455): 4.45e-21: 99.2: 15.06
+	Hs
		287765 MED6_HUMAN (1-246): 1.59e-147: 413: 100.00		RPB1_HUMAN (374-496): 2.4e-09: 62.2: 20.33
+	Ce
		594160 MED6_CAEEL (7-189): 1.64e-66: 208: 38.34		RPB1_CAEEL (223-392): 3.44e-17: 87.3: 15.88