Protein: MED6
Mediator of RNA polymerase II transcription subunit 6 (Activator-recruited cofactor 33 kDa component) (ARC33) (Mediator complex subunit 6) (hMed6) (Renal carcinoma antigen NY-REN-28)

Gene: MED6
Organism: Homo sapiens
Interactions: 99
UniProt ID: O75586

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0001223 - transcription coactivator binding
GO:0003677 - DNA binding
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

287771

CDK8
Cyclin-dependent kinase 8

16

4

Small-scale

0.985

High

287814

MED10
Mediator of RNA polymerase II transcription subunit 10

8

4

Small-scale

0.970

High

287816

CDK19
Cyclin-dependent kinase 19

6

4

High-throughput

0.947

High

287822

MED17
Mediator of RNA polymerase II transcription subunit 17

5

1

Small-scale

0.919

High

287790

MED22
Mediator of RNA polymerase II transcription subunit 22

3

3

High-throughput

0.861

High

287765

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

3

High-throughput

0.789

High

287809

MED8
Mediator of RNA polymerase II transcription subunit 8

2

1

High-throughput

0.789

High

287764

CCNC
Cyclin-C

7

2

Small-scale

0.741

High

287825

MED29
Mediator of RNA polymerase II transcription subunit 29

6

2

Small-scale

0.736

High

287786

MED21
Mediator of RNA polymerase II transcription subunit 21

6

1

Small-scale

0.734

High

287807

MED12
Mediator of RNA polymerase II transcription subunit 12

6

2

High-throughput

0.733

High

287817

MED28
Mediator of RNA polymerase II transcription subunit 28

6

1

Small-scale

0.732

High

48882

MED19
Mediator of RNA polymerase II transcription subunit 19

10

0

Small-scale

0.725

High

219462

MED7
Mediator of RNA polymerase II transcription subunit 7

5

4

High-throughput

0.722

High

287820

MED4
Mediator of RNA polymerase II transcription subunit 4

5

1

High-throughput

0.718

High

287815

MED18
Mediator of RNA polymerase II transcription subunit 18

5

2

Small-scale

0.718

High

287810

MED30
Mediator of RNA polymerase II transcription subunit 30

5

1

Small-scale

0.716

High

287791

MED1
Mediator of RNA polymerase II transcription subunit 1

7

0

Small-scale

0.714

High

287819

MED20
Mediator of RNA polymerase II transcription subunit 20

4

2

High-throughput

0.699

High

287828

MED23
Mediator of RNA polymerase II transcription subunit 23

4

1

Small-scale

0.691

High

287824

MED9
Mediator of RNA polymerase II transcription subunit 9

5

0

Small-scale

0.682

High

287801

MED25
Mediator of RNA polymerase II transcription subunit 25

4

2

Small-scale

0.672

High

282333

MED24
Mediator of RNA polymerase II transcription subunit 24

3

1

High-throughput

0.667

High

287748

MED26
Mediator of RNA polymerase II transcription subunit 26

3

1

High-throughput

0.667

High

287797

MED27
Mediator of RNA polymerase II transcription subunit 27

3

1

Small-scale

0.662

High

287752

ESR1
Estrogen receptor

3

4

Small-scale

0.660

High

287763

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.656

High

287768

SRBP1
Sterol regulatory element-binding protein 1

3

1

Small-scale

0.655

High

239511

MED14
Mediator of RNA polymerase II transcription subunit 14

3

5

Small-scale

0.650

High

287813

MED15
Mediator of RNA polymerase II transcription subunit 15

3

2

Small-scale

0.640

High

287832

MED31
Mediator of RNA polymerase II transcription subunit 31

2

3

High-throughput

0.628

High

287761

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

2

High-throughput

0.611

High

287766

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

2

High-throughput

0.611

High

287826

MED11
Mediator of RNA polymerase II transcription subunit 11

2

1

High-throughput

0.611

High

287831

MED16
Mediator of RNA polymerase II transcription subunit 16

2

1

High-throughput

0.611

High

188628

BIRC5
Baculoviral IAP repeat-containing protein 5

2

0

High-throughput

0.602

High

192765

RPB4
DNA-directed RNA polymerase II subunit RPB4

2

0

High-throughput

0.602

High

287762

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

2

0

High-throughput

0.602

High

287793

SMAD1
Mothers against decapentaplegic homolog 1

2

2

Small-scale

0.601

High

287827

MED13
Mediator of RNA polymerase II transcription subunit 13

2

3

High-throughput

0.601

High

287806

ESR2
Estrogen receptor beta

2

4

Small-scale

0.595

High

287777

RPB7
DNA-directed RNA polymerase II subunit RPB7

2

0

High-throughput

0.585

High

287759

VDR
Vitamin D3 receptor

2

3

Small-scale

0.584

High

287808

FBXW7
F-box/WD repeat-containing protein 7

2

1

Small-scale

0.584

High

287775

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

2

1

High-throughput

0.571

High

287754

PARP1
Poly [ADP-ribose] polymerase 1

2

0

Small-scale

0.569

High

287792

SMAD2
Mothers against decapentaplegic homolog 2

1

2

Small-scale

0.515

High

76420

B4DUB1
cyclin-dependent kinase

1

4

High-throughput

0.514

High

287750

CRYAA
Alpha-crystallin A chain

1

0

High-throughput

0.513

High

287760

EGR1
Early growth response protein 1

1

0

High-throughput

0.513

High

287798

FXL19
F-box/LRR-repeat protein 19

1

0

High-throughput

0.513

High

287821

KIF15
Kinesin-like protein KIF15

1

0

High-throughput

0.513

High

287772

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.505

High

287773

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

1

Small-scale

0.501

High

287833

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

1

Small-scale

0.501

High

287782

SRBP2
Sterol regulatory element-binding protein 2

1

1

Small-scale

0.500

High

287779

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.493

High

287787

CUL1
Cullin-1

1

0

Small-scale

0.493

High

287785

TADBP
TAR DNA-binding protein 43

1

1

Small-scale

0.481

High

287770

BCL6
B-cell lymphoma 6 protein

1

0

Small-scale

0.480

High

287789

SUZ12
Polycomb protein SUZ12

1

0

Small-scale

0.480

High

142761

NFIB
Nuclear factor 1 B-type

1

3

High-throughput

0.479

High

259220

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

283406

TAD2A
Transcriptional adapter 2-alpha

1

2

High-throughput

0.479

High

287747

SCAF4
SR-related and CTD-associated factor 4

1

1

High-throughput

0.479

High

287749

EYA4
Protein phosphatase EYA4

1

2

High-throughput

0.479

High

287753

NFIC
Nuclear factor 1 C-type

1

6

High-throughput

0.479

High

287756

ANDR
Androgen receptor

1

4

High-throughput

0.479

High

287757

RARA
Retinoic acid receptor alpha

1

4

Small-scale

0.479

High

287758

THA
Thyroid hormone receptor alpha

1

3

Small-scale

0.479

High

287767

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

2

High-throughput

0.479

High

287774

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

2

High-throughput

0.479

High

287781

SMAD3
Mothers against decapentaplegic homolog 3

1

2

Small-scale

0.479

High

287783

NFIA
Nuclear factor 1 A-type

1

4

High-throughput

0.479

High

287788

NFIX
Nuclear factor 1 X-type

1

4

High-throughput

0.479

High

287800

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

1

3

High-throughput

0.479

High

287802

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

1

2

High-throughput

0.479

High

287823

NLE1
Notchless protein homolog 1

1

2

High-throughput

0.479

High

287829

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.479

High

287830

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.479

High

287746

UBR5
E3 ubiquitin-protein ligase UBR5

1

0

High-throughput

0.458

High

287769

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

287776

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

287778

H4
Histone H4

1

0

High-throughput

0.458

High

287780

SKP1
S-phase kinase-associated protein 1

1

0

Small-scale

0.458

High

287784

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

287794

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

0

High-throughput

0.458

High

287799

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.458

High

287803

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

0

High-throughput

0.458

High

287804

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

0

Small-scale

0.458

High

287811

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

0

Small-scale

0.458

High

287812

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

287818

STN1
CST complex subunit STN1

1

0

High-throughput

0.458

High

95742

E5RFK5
Cyclin-C

1

2

High-throughput

0.445

High

287795

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.437

High

287805

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

287751

APOA2
Apolipoprotein A-II

1

0

High-throughput

0.249

Low

287796

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

0

High-throughput

0.249

Low

287755

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025