Protein: SRBP1
Sterol regulatory element-binding protein 1 (SREBP-1) (Class D basic helix-loop-helix protein 1) (bHLHd1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1 (Transcription factor SREBF1)]

Gene: SRBP1, SREBF1
Organism: Homo sapiens
Interactions: 104
UniProt ID: P36956

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000139 - Golgi membrane
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

787890

FBXW7
F-box/WD repeat-containing protein 7

8

13

Small-scale

0.753

High

787885

CBP
CREB-binding protein

5

20

Small-scale

0.725

High

787893

MED15
Mediator of RNA polymerase II transcription subunit 15

5

20

Small-scale

0.721

High

787863

EP300
Histone acetyltransferase p300

5

20

Small-scale

0.720

High

648332

USF1
Upstream stimulatory factor 1

1

18

Small-scale

0.691

High

787864

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

4

17

Small-scale

0.686

High

385512

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

3

5

Small-scale

0.685

High

787882

TWST2
Twist-related protein 2

1

11

Small-scale

0.680

High

787902

MED23
Mediator of RNA polymerase II transcription subunit 23

3

1

Small-scale

0.664

High

287768

MED6
Mediator of RNA polymerase II transcription subunit 6

3

1

Small-scale

0.655

High

787892

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

6

Small-scale

0.650

High

787844

SRBP1
Sterol regulatory element-binding protein 1

1

15

Small-scale

0.647

High

787859

ID2
DNA-binding protein inhibitor ID-2

1

1

Small-scale

0.647

High

787860

ID3
DNA-binding protein inhibitor ID-3

1

1

Small-scale

0.647

High

787865

SRBP2
Sterol regulatory element-binding protein 2

1

18

Small-scale

0.647

High

239545

MED14
Mediator of RNA polymerase II transcription subunit 14

3

16

Small-scale

0.641

High

282359

MED24
Mediator of RNA polymerase II transcription subunit 24

3

1

Small-scale

0.641

High

787889

MED12
Mediator of RNA polymerase II transcription subunit 12

3

16

Small-scale

0.641

High

632930

PRVA
Parvalbumin alpha

2

1

High-throughput

0.628

High

787884

SORL
Sortilin-related receptor

2

4

High-throughput

0.628

High

787854

ATX1
Ataxin-1

2

5

High-throughput

0.620

High

335964

MED26
Mediator of RNA polymerase II transcription subunit 26

3

0

Small-scale

0.613

High

787901

MED13
Mediator of RNA polymerase II transcription subunit 13

3

0

Small-scale

0.613

High

787848

CDK8
Cyclin-dependent kinase 8

2

15

Small-scale

0.613

High

787873

MED1
Mediator of RNA polymerase II transcription subunit 1

2

11

Small-scale

0.608

High

787849

GSK3B
Glycogen synthase kinase-3 beta

2

12

Small-scale

0.602

High

787845

HNF4A
Hepatocyte nuclear factor 4-alpha

2

20

Small-scale

0.595

High

787877

MED25
Mediator of RNA polymerase II transcription subunit 25

2

4

Small-scale

0.595

High

219476

MED7
Mediator of RNA polymerase II transcription subunit 7

2

0

Small-scale

0.592

High

464848

SP1
Transcription factor Sp1

2

18

Small-scale

0.585

High

787906

TRRAP
Transformation/transcription domain-associated protein

2

8

Small-scale

0.584

High

787869

DX39B
Spliceosome RNA helicase DDX39B

1

12

Small-scale

0.573

High

787899

MED17
Mediator of RNA polymerase II transcription subunit 17

2

0

Small-scale

0.569

High

162489

ANM5
Protein arginine N-methyltransferase 5

1

9

Small-scale

0.561

High

519798

ANDR
Androgen receptor

1

20

Small-scale

0.561

High

787853

PLK1
Serine/threonine-protein kinase PLK1

1

8

Small-scale

0.561

High

787887

SMRC1
SWI/SNF complex subunit SMARCC1

1

9

Small-scale

0.561

High

787896

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

8

Small-scale

0.561

High

51760

ZBT7C
Zinc finger and BTB domain-containing protein 7C

1

8

Small-scale

0.552

High

691651

MK03
Mitogen-activated protein kinase 3

1

8

Small-scale

0.550

High

703466

MK01
Mitogen-activated protein kinase 1

1

8

Small-scale

0.550

High

66425

ASB14
Ankyrin repeat and SOCS box protein 14

1

3

High-throughput

0.536

High

572907

INSRR
Insulin receptor-related protein

1

15

High-throughput

0.536

High

784819

ACHA7
Neuronal acetylcholine receptor subunit alpha-7

1

2

High-throughput

0.536

High

787871

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

1

High-throughput

0.536

High

787874

TTMP
TPA-induced transmembrane protein

1

2

High-throughput

0.536

High

787881

KCNG4
Voltage-gated potassium channel regulatory subunit KCNG4

1

5

High-throughput

0.536

High

787852

NR0B1
Nuclear receptor subfamily 0 group B member 1

1

20

Small-scale

0.527

High

787846

HD
Huntingtin

1

5

High-throughput

0.515

High

787847

MTR1B
Melatonin receptor type 1B

1

4

High-throughput

0.508

High

137529

NR5A2
Nuclear receptor subfamily 5 group A member 2

1

20

Small-scale

0.501

High

634331

LMNB1
Lamin-B1

1

7

Small-scale

0.501

High

675388

TYY1
Transcriptional repressor protein YY1

1

6

Small-scale

0.501

High

787876

SMRD3
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

1

6

Small-scale

0.501

High

787905

KLF13
Krueppel-like factor 13

1

20

Small-scale

0.501

High

787875

TM268
Transmembrane protein 268

1

1

High-throughput

0.489

High

787897

TMM9B
Transmembrane protein 9B

1

1

High-throughput

0.489

High

505529

ATX1L
Ataxin-1-like

1

5

High-throughput

0.481

High

787861

MECOM
Histone-lysine N-methyltransferase MECOM

1

1

High-throughput

0.481

High

128816

MEN1
Menin

1

3

Small-scale

0.479

High

192459

INSI1
Insulin-induced gene 1 protein

1

4

Small-scale

0.479

High

217906

TGON2
Trans-Golgi network integral membrane protein 2

1

7

High-throughput

0.479

High

240933

PRKN
E3 ubiquitin-protein ligase parkin

1

13

High-throughput

0.479

High

254479

PLPL9
85/88 kDa calcium-independent phospholipase A2

1

5

Small-scale

0.479

High

279123

ULK1
Serine/threonine-protein kinase ULK1

1

3

Small-scale

0.479

High

284806

TADA3
Transcriptional adapter 3

1

1

Small-scale

0.479

High

321195

ERLN2
Erlin-2

1

4

Small-scale

0.479

High

334515

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

10

Small-scale

0.479

High

413319

P53
Cellular tumor antigen p53

1

14

Small-scale

0.479

High

443235

CDK1
Cyclin-dependent kinase 1

1

4

Small-scale

0.479

High

461223

HS90A
Heat shock protein HSP 90-alpha

1

12

High-throughput

0.479

High

468138

HS90B
Heat shock protein HSP 90-beta

1

12

High-throughput

0.479

High

573766

CCNB1
G2/mitotic-specific cyclin-B1

1

1

Small-scale

0.479

High

623156

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

Small-scale

0.479

High

643349

OSBP1
Oxysterol-binding protein 1

1

1

Small-scale

0.479

High

667198

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

3

Small-scale

0.479

High

787850

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

17

Small-scale

0.479

High

787851

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

17

Small-scale

0.479

High

787855

H4
Histone H4

1

11

High-throughput

0.479

High

787856

UBC9
SUMO-conjugating enzyme UBC9

1

5

Small-scale

0.479

High

787857

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.479

High

787858

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

Small-scale

0.479

High

787862

TF65
Transcription factor p65

1

11

Small-scale

0.479

High

787866

ATM
Serine-protein kinase ATM

1

8

Small-scale

0.479

High

787867

MED21
Mediator of RNA polymerase II transcription subunit 21

1

1

Small-scale

0.479

High

787868

HDAC1
Histone deacetylase 1

1

12

Small-scale

0.479

High

787870

KLF5
Krueppel-like factor 5

1

20

Small-scale

0.479

High

787872

ZN638
Zinc finger protein 638

1

2

Small-scale

0.479

High

787878

TAD2B
Transcriptional adapter 2-beta

1

4

Small-scale

0.479

High

787883

GCN1
Stalled ribosome sensor GCN1

1

8

Small-scale

0.479

High

787886

KAT2A
Histone acetyltransferase KAT2A

1

20

Small-scale

0.479

High

787888

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

6

Small-scale

0.479

High

787891

SYTL4
Synaptotagmin-like protein 4

1

1

High-throughput

0.479

High

787894

SIN3A
Paired amphipathic helix protein Sin3a

1

1

Small-scale

0.479

High

787895

SPRNG
SREBP regulating gene protein

1

1

Small-scale

0.479

High

787898

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

2

Small-scale

0.479

High

787900

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

Small-scale

0.479

High

787903

RUVB2
RuvB-like 2

1

4

Small-scale

0.479

High

787907

INSI2
Insulin-induced gene 2 protein

1

4

Small-scale

0.479

High

787879

RYBP
RING1 and YY1-binding protein

1

3

High-throughput

0.445

High

787904

S27A6
Long-chain fatty acid transport protein 6

1

4

High-throughput

0.445

High

376587

EGF
Pro-epidermal growth factor

1

4

Small-scale

0.437

High

787880

GOLM1
Golgi membrane protein 1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025