HitPredict

Interactor 1: DNM3A (O88508)
DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (Cysteine methyltransferase DNMT3A) (EC 2.1.1.-) (DNA methyltransferase MmuIIIA) (DNA MTase MmuIIIA) (M.MmuIIIA)
Gene: Dnmt3a

Interactor 2: H33 (P84244)
Histone H3.3
Gene: H3-3a

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	20211137
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~PWWP
Common GO terms	GO:0000775 - chromosome, centromeric region GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0007283 - spermatogenesis
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 908 Mm			1 136
+	Hs
		935442 DNM3A_HUMAN (1-908): 0: 1584: 96.26		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		952734 DNM3A_HUMAN (1-908): 0: 1584: 96.26		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		828439 DNM3A_HUMAN (1-908): 0: 1584: 96.26		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76
+	Hs
		935328 DNM3B_HUMAN (147-907): 0: 1268: 53.07		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		952687 DNM3L_HUMAN (472-811): 2.96e-179: 524: 40.18		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		1174681 DNM3L_HUMAN (472-811): 2.96e-179: 524: 40.18		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Hs
		935132 PWP2A_HUMAN (240-373): 1.01e-37: 153: 24.82		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		952557 PWP2A_HUMAN (240-373): 1.01e-37: 153: 24.82		H33_HUMAN (1-136): 1.12e-59: 182: 100.00