Protein: CXB2
Gap junction beta-2 protein (Connexin-26) (Cx26)

Gene: CXB2, GJB2
Organism: Homo sapiens
Interactions: 68
UniProt ID: P29033

Gene Ontology (top 5):
GO:0005243 - gap junction channel activity
GO:0005509 - calcium ion binding
GO:0005793 - endoplasmic reticulum-Golgi intermediate compartment
GO:0005886 - plasma membrane
GO:0005921 - gap junction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

706010

CXB2
Gap junction beta-2 protein

2

15

Small-scale

0.793

High

464678

CXB1
Gap junction beta-1 protein

2

15

High-throughput

0.783

High

706014

CXA5
Gap junction alpha-5 protein

2

15

High-throughput

0.783

High

706015

CXA8
Gap junction alpha-8 protein

2

16

High-throughput

0.783

High

706063

CXA3
Gap junction alpha-3 protein

1

16

High-throughput

0.691

High

194678

FFAR2
Free fatty acid receptor 2

2

12

High-throughput

0.606

High

332783

KCNK5
Potassium channel subfamily K member 5

2

1

High-throughput

0.606

High

688529

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

2

4

High-throughput

0.606

High

706012

TRFR
Thyrotropin-releasing hormone receptor

2

6

High-throughput

0.606

High

706013

APJ
Apelin receptor

2

8

High-throughput

0.606

High

706032

MFSD6
Major facilitator superfamily domain-containing protein 6

2

1

High-throughput

0.606

High

706038

LHPL5
LHFPL tetraspan subfamily member 5 protein

2

6

High-throughput

0.606

High

706039

GP152
Probable G-protein coupled receptor 152

2

11

High-throughput

0.606

High

706049

ZNT2
Proton-coupled zinc antiporter SLC30A2

2

14

High-throughput

0.606

High

706055

LRC4C
Leucine-rich repeat-containing protein 4C

2

3

High-throughput

0.606

High

706042

T106A
Transmembrane protein 106A

2

0

High-throughput

0.580

High

706044

M4A6E
Membrane-spanning 4-domains subfamily A member 6E

2

0

High-throughput

0.580

High

706047

TM237
Transmembrane protein 237

2

0

High-throughput

0.580

High

706016

VMAT1
Chromaffin granule amine transporter

2

1

High-throughput

0.553

High

706021

AQP6
Aquaporin-6

2

4

High-throughput

0.553

High

706022

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

2

2

High-throughput

0.553

High

706025

AR13B
ADP-ribosylation factor-like protein 13B

2

6

High-throughput

0.553

High

706034

DHB13
17-beta-hydroxysteroid dehydrogenase 13

2

2

High-throughput

0.553

High

706035

AMGO1
Amphoterin-induced protein 1

2

8

High-throughput

0.553

High

706057

SAR1A
Small COPII coat GTPase SAR1A

2

6

High-throughput

0.553

High

706060

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

2

1

High-throughput

0.553

High

390468

TFR1
Transferrin receptor protein 1

1

3

High-throughput

0.536

High

669298

ACKR3
Atypical chemokine receptor 3

1

10

High-throughput

0.536

High

706011

CCR1
C-C chemokine receptor type 1

1

10

High-throughput

0.536

High

706026

ZACN
Ligand-gated cation channel ZACN

1

6

High-throughput

0.536

High

706037

INADL
InaD-like protein

1

11

High-throughput

0.536

High

706045

S35E1
Solute carrier family 35 member E1

1

1

High-throughput

0.536

High

706048

S38A2
Sodium-coupled neutral amino acid symporter 2

1

7

High-throughput

0.536

High

706053

ANTR1
Anthrax toxin receptor 1

1

2

High-throughput

0.536

High

706059

PACN3
Protein kinase C and casein kinase substrate in neurons protein 3

1

3

High-throughput

0.536

High

471537

CD14
Monocyte differentiation antigen CD14

1

0

High-throughput

0.518

High

193396

GPR42
G-protein coupled receptor 42

1

12

High-throughput

0.515

High

706019

Q0VAB0
Thromboxane A2 receptor

1

10

High-throughput

0.515

High

706041

PIEZ1
Piezo-type mechanosensitive ion channel component 1

1

0

High-throughput

0.513

High

706052

MUC13
Mucin-13

1

0

High-throughput

0.513

High

706031

CNST
Consortin

1

11

Small-scale

0.501

High

249573

SNX3
Sorting nexin-3

1

2

High-throughput

0.489

High

706020

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

6

High-throughput

0.489

High

706033

RFIP2
Rab11 family-interacting protein 2

1

7

High-throughput

0.489

High

640490

TA2R
Thromboxane A2 receptor

1

9

High-throughput

0.481

High

706023

SOAT
Sodium-dependent organic anion transporter

1

1

High-throughput

0.481

High

706018

CAV1
Caveolin-1

1

3

Small-scale

0.479

High

230266

CREB3
Cyclic AMP-responsive element-binding protein 3

1

1

High-throughput

0.439

High

385477

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

9

High-throughput

0.439

High

706028

TMM31
Transmembrane protein 31

1

1

High-throughput

0.439

High

706029

A16L1
Autophagy-related protein 16-1

1

4

Small-scale

0.437

High

706051

ATG5
Autophagy protein 5

1

2

Small-scale

0.437

High

142083

PEX12
Peroxisome assembly protein 12

2

0

High-throughput

0.316

High

706024

SHSL1
Protein shisa-like-1

2

0

High-throughput

0.316

High

706027

F209A
Protein FAM209A

2

0

High-throughput

0.316

High

706036

TEX29
Testis-expressed protein 29

2

0

High-throughput

0.316

High

706040

SSMM1
Serine-rich single-pass membrane protein 1

2

0

High-throughput

0.316

High

706043

PKHB2
Pleckstrin homology domain-containing family B member 2

2

0

High-throughput

0.316

High

706046

TLCD4
TLC domain-containing protein 4

2

0

High-throughput

0.316

High

706050

TM2D2
TM2 domain-containing protein 2

2

0

High-throughput

0.316

High

706056

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

2

0

High-throughput

0.316

High

706062

TMX2
Thioredoxin-related transmembrane protein 2

2

0

High-throughput

0.316

High

706058

FBX2
F-box only protein 2

1

0

Small-scale

0.292

High

706030

TM154
Transmembrane protein 154

1

0

High-throughput

0.279

Low

706054

CLSPN
Claspin

1

0

High-throughput

0.279

Low

706061

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.279

Low

706017

SKP1
S-phase kinase-associated protein 1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025