HitPredict - High confidence protein-protein interactions

Interactor 1: AXIN2 (O88566)
Axin-2 (Axin-like protein) (Axil) (Axis inhibition protein 2) (Conductin)
Gene: AXIN2

Interactor 2: CTNB1 (Q02248)
Catenin beta-1 (Beta-catenin)
Gene: Ctnnb1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.793

Property	Details
Experiments	9554852, 25873176
Identification Methods	two hybrid, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Arm~Axin_b-cat_bind
Common GO terms	GO:0001649 - osteoblast differentiation GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0005886 - plasma membrane and 14 others more... GO:0008104 - protein localization GO:0008283 - cell population proliferation GO:0008285 - negative regulation of cell population proliferation GO:0009950 - dorsal/ventral axis specification GO:0010718 - positive regulation of epithelial to mesenchymal transition GO:0019901 - protein kinase binding GO:0030877 - beta-catenin destruction complex GO:0032991 - protein-containing complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0060070 - canonical Wnt signaling pathway GO:0070411 - I-SMAD binding GO:0070602 - regulation of centromeric sister chromatid cohesion GO:0072089 - stem cell proliferation GO:0090090 - negative regulation of canonical Wnt signaling pathway
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1	840
Mm

1	781

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024