HitPredict

Interactor 1: PKHG5 (O94827)
Pleckstrin homology domain-containing family G member 5 (PH domain-containing family G member 5) (Guanine nucleotide exchange factor 720) (GEF720)
Gene: PLEKHG5

Interactor 2: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1006 Hs			1 247
+	Hs
		297126 PKHG5_HUMAN (1-1006): 0: 804: 100.00		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		297128 PKHG5_HUMAN (1-1006): 0: 804: 100.00		1433F_HUMAN (1-246): 2.5e-135: 382: 86.99
+	Hs
		297120 PKHG5_HUMAN (1-1006): 0: 804: 100.00		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		297127 PKHG5_HUMAN (1-1006): 0: 804: 100.00		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		297119 PKHG5_HUMAN (1-1006): 0: 804: 100.00		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		905120 PKHG2_HUMAN (331-978): 1.26e-96: 335: 19.10		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	Hs
		909883 ARHG2_HUMAN (215-990): 4.66e-94: 322: 16.51		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		982506 PKHG2_HUMAN (331-978): 1.26e-96: 335: 19.10		1433F_HUMAN (1-246): 2.5e-135: 382: 86.99
+	Hs
		904950 ARHG2_HUMAN (215-990): 4.66e-94: 322: 16.51		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	Hs
		982358 ARHG2_HUMAN (215-990): 4.66e-94: 322: 16.51		1433F_HUMAN (1-246): 2.5e-135: 382: 86.99
+	Mm
		935597 FARP2_MOUSE (123-757): 2.14e-86: 302: 15.54		1433F_MOUSE (1-246): 1.51e-136: 385: 86.99
+	Hs
		683603 ARHG2_HUMAN (215-990): 4.66e-94: 322: 16.51		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		927379 ARHG2_HUMAN (215-990): 4.66e-94: 322: 16.51		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Mm
		926797 ARHG2_MOUSE (198-990): 3.5e-93: 320: 15.23		1433Z_MOUSE (2-245): 8.46e-109: 315: 74.59
+	Hs
		647169 ARHG2_HUMAN (215-990): 4.66e-94: 322: 16.51		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Mm
		926817 ARHGI_MOUSE (150-866): 3.36e-85: 303: 17.88		1433Z_MOUSE (2-245): 8.46e-109: 315: 74.59
+	Hs
		683335 RGRF1_HUMAN (269-980): 3.39e-84: 298: 13.04		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		927198 ARHGI_HUMAN (150-874): 7.01e-85: 301: 16.86		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		684253 ARHG2_HUMAN (215-990): 4.66e-94: 322: 16.51		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16
+	Hs
		647028 FGD6_HUMAN (152-838): 1.41e-83: 298: 16.52		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33