Protein: PRAF3
PRA1 family protein 3 (ADP-ribosylation factor-like protein 6-interacting protein 5) (ARL-6-interacting protein 5) (Aip-5) (Cytoskeleton-related vitamin A-responsive protein) (Dermal papilla-derived protein 11) (GTRAP3-18) (Glutamate transporter EAAC1-interacting protein) (JM5) (Prenylated Rab acceptor protein 2) (Protein JWa) (Putative MAPK-activating protein PM27)

Gene: PRAF3, ARL6IP5
Organism: Homo sapiens
Interactions: 193
UniProt ID: O75915

Gene Ontology (top 5):
GO:0002037 - negative regulation of L-glutamate import across plasma membrane
GO:0005789 - endoplasmic reticulum membrane
GO:0005856 - cytoskeleton
GO:0005886 - plasma membrane
GO:0006749 - glutathione metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

297274

RTN4
Reticulon-4

4

10

High-throughput

0.699

High

297223

RETR3
Reticulophagy regulator 3

4

3

Small-scale

0.694

High

63880

5HT3E
5-hydroxytryptamine receptor 3E

3

1

High-throughput

0.667

High

297149

FPR2
N-formyl peptide receptor 2

3

3

High-throughput

0.662

High

257590

PRAF2
PRA1 family protein 2

3

5

Small-scale

0.650

High

297138

ICAM2
Intercellular adhesion molecule 2

3

0

High-throughput

0.638

High

297179

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

3

0

High-throughput

0.638

High

297247

RN185
E3 ubiquitin-protein ligase RNF185

2

2

Small-scale

0.631

High

252571

TSN2
Tetraspanin-2

2

4

High-throughput

0.628

High

297123

S1PR2
Sphingosine 1-phosphate receptor 2

2

5

High-throughput

0.628

High

297159

VIPR1
Vasoactive intestinal polypeptide receptor 1

2

1

High-throughput

0.628

High

297283

C5AR2
C5a anaphylatoxin chemotactic receptor 2

2

6

High-throughput

0.628

High

297128

RASK
GTPase KRas

2

6

High-throughput

0.614

High

297169

LPAR6
Lysophosphatidic acid receptor 6

2

3

High-throughput

0.611

High

297197

IFM3
Interferon-induced transmembrane protein 3

2

2

High-throughput

0.611

High

297220

TM11B
Transmembrane protease serine 11B

2

2

High-throughput

0.611

High

297258

ESYT1
Extended synaptotagmin-1

2

3

High-throughput

0.611

High

297260

DERL1
Derlin-1

2

2

High-throughput

0.611

High

297266

P2Y12
P2Y purinoceptor 12

2

4

High-throughput

0.611

High

297134

GLPB
Glycophorin-B

2

0

High-throughput

0.602

High

297150

NK1R
Substance-P receptor

2

0

High-throughput

0.602

High

297226

F241A
Uncharacterized protein FAM241A

2

1

High-throughput

0.601

High

297237

LPAR1
Lysophosphatidic acid receptor 1

2

5

High-throughput

0.601

High

297147

EVI2A
Protein EVI2A

2

0

High-throughput

0.585

High

297174

RAB7A
Ras-related protein Rab-7a

2

9

Small-scale

0.584

High

297180

SC61B
Protein transport protein Sec61 subunit beta

2

1

High-throughput

0.584

High

297196

REEP5
Receptor expression-enhancing protein 5

2

8

High-throughput

0.558

High

297166

CCR2
C-C chemokine receptor type 2

1

4

High-throughput

0.541

High

297167

EAA3
Excitatory amino acid transporter 3

1

0

Small-scale

0.537

High

50756

TSN11
Tetraspanin-11

1

5

High-throughput

0.536

High

124996

KCNK1
Potassium channel subfamily K member 1

1

1

High-throughput

0.536

High

132543

UPK1A
Uroplakin-1a

1

5

High-throughput

0.536

High

141803

ACKR2
Atypical chemokine receptor 2

1

4

High-throughput

0.536

High

158068

COPE
Coatomer subunit epsilon

1

1

High-throughput

0.536

High

167150

T4S5
Transmembrane 4 L6 family member 5

1

1

High-throughput

0.536

High

297124

RTN3
Reticulon-3

1

10

High-throughput

0.536

High

297125

TSN15
Tetraspanin-15

1

4

High-throughput

0.536

High

297126

S1PR4
Sphingosine 1-phosphate receptor 4

1

6

High-throughput

0.536

High

297136

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.536

High

297145

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

5

High-throughput

0.536

High

297152

1433T
14-3-3 protein theta

1

5

High-throughput

0.536

High

297158

1433B
14-3-3 protein beta/alpha

1

5

High-throughput

0.536

High

297161

CNR2
Cannabinoid receptor 2

1

5

Small-scale

0.536

High

297186

COPZ1
Coatomer subunit zeta-1

1

1

High-throughput

0.536

High

297188

1433G
14-3-3 protein gamma

1

5

High-throughput

0.536

High

297199

1433F
14-3-3 protein eta

1

5

High-throughput

0.536

High

297203

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

1

High-throughput

0.536

High

297205

MOG
Myelin-oligodendrocyte glycoprotein

1

1

High-throughput

0.536

High

297209

RTN1
Reticulon-1

1

10

High-throughput

0.536

High

297227

ZDH22
Palmitoyltransferase ZDHHC22

1

1

High-throughput

0.536

High

297232

ATLA2
Atlastin-2

1

1

High-throughput

0.536

High

297240

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

5

High-throughput

0.536

High

297245

F241B
Protein FAM241B

1

1

High-throughput

0.536

High

297246

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

2

High-throughput

0.536

High

297261

TX101
Testis-expressed protein 101

1

2

High-throughput

0.536

High

297263

DERL2
Derlin-2

1

2

High-throughput

0.536

High

297268

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

1

1

High-throughput

0.536

High

297272

LPAR2
Lysophosphatidic acid receptor 2

1

6

High-throughput

0.536

High

297290

SC6A5
Sodium- and chloride-dependent glycine transporter 2

1

1

High-throughput

0.536

High

287834

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

0

High-throughput

0.518

High

297170

NOTC1
Neurogenic locus notch homolog protein 1

1

0

High-throughput

0.518

High

180455

PLS1
Phospholipid scramblase 1

1

0

High-throughput

0.513

High

297155

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

0

High-throughput

0.513

High

297163

DHB2
17-beta-hydroxysteroid dehydrogenase type 2

1

0

High-throughput

0.513

High

297164

GPV
Platelet glycoprotein V

1

0

High-throughput

0.513

High

297178

EFNA4
Ephrin-A4

1

0

High-throughput

0.513

High

297183

ARP2
Actin-related protein 2

1

0

High-throughput

0.513

High

297189

1433E
14-3-3 protein epsilon

1

0

High-throughput

0.513

High

297234

T170A
Transmembrane protein 170A

1

0

High-throughput

0.513

High

297242

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

297244

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.513

High

297252

TECTB
Beta-tectorin

1

0

High-throughput

0.513

High

297255

SGMR1
Sigma non-opioid intracellular receptor 1

1

0

High-throughput

0.513

High

297256

PRRT1
Proline-rich transmembrane protein 1

1

0

High-throughput

0.513

High

297259

TMM43
Transmembrane protein 43

1

0

High-throughput

0.513

High

297279

GP173
Probable G-protein coupled receptor 173

1

0

High-throughput

0.513

High

297285

COPG2
Coatomer subunit gamma-2

1

0

High-throughput

0.513

High

297187

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

0

High-throughput

0.493

High

179101

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

2

High-throughput

0.489

High

297194

1433Z
14-3-3 protein zeta/delta

1

5

High-throughput

0.489

High

297198

LMNB2
Lamin-B2

1

5

High-throughput

0.489

High

297224

S22A9
Organic anion transporter 7

1

1

High-throughput

0.489

High

297239

ARC1A
Actin-related protein 2/3 complex subunit 1A

1

2

High-throughput

0.489

High

297264

ARL6
ADP-ribosylation factor-like protein 6

1

6

Small-scale

0.481

High

48465

ESYT2
Extended synaptotagmin-2

1

3

High-throughput

0.479

High

126406

RHOD
Rho-related GTP-binding protein RhoD

1

9

High-throughput

0.479

High

173800

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

5

High-throughput

0.479

High

188751

TMPS2
Transmembrane protease serine 2

1

2

High-throughput

0.479

High

297127

RASN
GTPase NRas

1

6

High-throughput

0.479

High

297131

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

1

High-throughput

0.479

High

297132

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.479

High

297135

RHOC
Rho-related GTP-binding protein RhoC

1

7

High-throughput

0.479

High

297137

UBL4A
Ubiquitin-like protein 4A

1

1

High-throughput

0.479

High

297139

RAC2
Ras-related C3 botulinum toxin substrate 2

1

5

High-throughput

0.479

High

297143

ATP4A
Potassium-transporting ATPase alpha chain 1

1

4

Small-scale

0.479

High

297144

LMNB1
Lamin-B1

1

5

High-throughput

0.479

High

297154

MARCS
Myristoylated alanine-rich C-kinase substrate

1

1

High-throughput

0.479

High

297173

RAB5C
Ras-related protein Rab-5C

1

9

High-throughput

0.479

High

297175

BAP31
B-cell receptor-associated protein 31

1

1

High-throughput

0.479

High

297176

CCR5
C-C chemokine receptor type 5

1

4

Small-scale

0.479

High

297177

RND2
Rho-related GTP-binding protein RhoN

1

14

High-throughput

0.479

High

297181

RAC3
Ras-related C3 botulinum toxin substrate 3

1

5

High-throughput

0.479

High

297182

CDC42
Cell division control protein 42 homolog

1

5

High-throughput

0.479

High

297185

RHOA
Transforming protein RhoA

1

8

High-throughput

0.479

High

297190

ARF6
ADP-ribosylation factor 6

1

5

High-throughput

0.479

High

297191

RHOB
Rho-related GTP-binding protein RhoB

1

8

High-throughput

0.479

High

297193

RAC1
Ras-related C3 botulinum toxin substrate 1

1

5

High-throughput

0.479

High

297200

CKAP4
Cytoskeleton-associated protein 4

1

1

High-throughput

0.479

High

297204

RHOH
Rho-related GTP-binding protein RhoH

1

11

High-throughput

0.479

High

297212

TM128
Transmembrane protein 128

1

3

High-throughput

0.479

High

297215

TECT3
Tectonic-3

1

3

High-throughput

0.479

High

297217

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

297222

PAQR2
Adiponectin receptor protein 2

1

1

Small-scale

0.479

High

297225

CXD3
Gap junction delta-3 protein

1

3

High-throughput

0.479

High

297235

5HT3C
5-hydroxytryptamine receptor 3C

1

1

High-throughput

0.479

High

297241

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

1

High-throughput

0.479

High

297248

TECT2
Tectonic-2

1

3

High-throughput

0.479

High

297250

DNJC1
DnaJ homolog subfamily C member 1

1

1

High-throughput

0.479

High

297254

SEC62
Translocation protein SEC62

1

1

High-throughput

0.479

High

297262

LNP
Endoplasmic reticulum junction formation protein lunapark

1

1

High-throughput

0.479

High

297267

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

1

High-throughput

0.479

High

297270

RETR1
Reticulophagy regulator 1

1

3

Small-scale

0.479

High

297271

RHOF
Rho-related GTP-binding protein RhoF

1

9

High-throughput

0.479

High

297278

TMPS4
Transmembrane protease serine 4

1

2

High-throughput

0.479

High

297281

ELOV5
Very long chain fatty acid elongase 5

1

2

High-throughput

0.479

High

297284

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

1

High-throughput

0.479

High

297288

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.479

High

297289

LAMP3
Lysosome-associated membrane glycoprotein 3

1

2

High-throughput

0.479

High

49276

SHOT1
Shootin-1

1

1

High-throughput

0.470

High

297275

MID51
Mitochondrial dynamics protein MIEF1

1

2

High-throughput

0.470

High

297257

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

0

Small-scale

0.460

High

297286

CLN8
Protein CLN8

1

0

Small-scale

0.460

High

292043

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

0

High-throughput

0.458

High

297130

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

297146

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.458

High

297151

DDX6
Probable ATP-dependent RNA helicase DDX6

1

0

High-throughput

0.458

High

297157

CPSM
Carbamoyl-phosphate synthase [ammonia], mitochondrial

1

0

High-throughput

0.458

High

297165

CEAM6
Cell adhesion molecule CEACAM6

1

0

High-throughput

0.458

High

297168

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

297172

EMD
Emerin

1

0

High-throughput

0.458

High

297192

RL10A
Large ribosomal subunit protein uL1

1

0

High-throughput

0.458

High

297207

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.458

High

297211

TM41B
Transmembrane protein 41B

1

0

High-throughput

0.458

High

297218

GAK6
Endogenous retrovirus group K member 6 Gag polyprotein

1

0

High-throughput

0.458

High

297221

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

0

High-throughput

0.458

High

297230

T185A
Transmembrane protein 185A

1

0

High-throughput

0.458

High

297231

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

297233

RHBL4
Rhomboid-related protein 4

1

0

High-throughput

0.458

High

297243

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

297265

DJC25
DnaJ homolog subfamily C member 25

1

0

High-throughput

0.458

High

297269

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

297276

NPDC1
Neural proliferation differentiation and control protein 1

1

0

High-throughput

0.458

High

297277

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.458

High

297282

TM216
Transmembrane protein 216

1

0

High-throughput

0.458

High

85141

B7Z3K1
cDNA FLJ51973

1

3

High-throughput

0.445

High

211099

CTR4
Cationic amino acid transporter 4

1

2

High-throughput

0.445

High

297160

CD80
T-lymphocyte activation antigen CD80

1

1

High-throughput

0.445

High

297216

GTR7
Solute carrier family 2, facilitated glucose transporter member 7

1

1

High-throughput

0.445

High

297129

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

5

High-throughput

0.437

High

297140

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

297153

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

297162

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

297195

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.437

High

297228

DHB11
Estradiol 17-beta-dehydrogenase 11

1

2

High-throughput

0.437

High

297238

ESR2
Estrogen receptor beta

1

2

High-throughput

0.437

High

297201

TRDN
Triadin

1

0

High-throughput

0.426

High

297213

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.426

High

297229

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.426

High

297249

TM169
Transmembrane protein 169

1

0

High-throughput

0.426

High

297133

ISG15
Ubiquitin-like protein ISG15

1

1

Small-scale

0.407

High

179280

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

High-throughput

0.279

Low

297148

H2B1O
Histone H2B type 1-O

1

0

High-throughput

0.279

Low

297156

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.279

Low

297273

DMAP1
DNA methyltransferase 1-associated protein 1

1

0

High-throughput

0.279

Low

733

MEIKN
Meiosis-specific kinetochore protein

1

0

High-throughput

0.269

Low

297202

HDAC1
Histone deacetylase 1

1

0

High-throughput

0.269

Low

297208

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

0

High-throughput

0.269

Low

104974

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

133144

LORF2
LINE-1 retrotransposable element ORF2 protein

1

0

High-throughput

0.249

Low

297122

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

0

High-throughput

0.249

Low

297141

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.249

Low

297142

XRCC1
DNA repair protein XRCC1

1

0

Small-scale

0.249

Low

297171

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.249

Low

297184

RS3A
Small ribosomal subunit protein eS1

1

0

High-throughput

0.249

Low

297206

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.249

Low

297214

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

297219

KI21A
Kinesin-like protein KIF21A

1

0

High-throughput

0.249

Low

297236

ASB11
Ankyrin repeat and SOCS box protein 11

1

0

High-throughput

0.249

Low

297251

SCLT1
Sodium channel and clathrin linker 1

1

0

High-throughput

0.249

Low

297253

MINT
Msx2-interacting protein

1

0

High-throughput

0.249

Low

297280

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

297287

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

297210

LETM2
LETM1 domain-containing protein LETM2, mitochondrial

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025