HitPredict

Interactor 1: PRP6 (O94906)
Pre-mRNA-processing factor 6 (Androgen receptor N-terminal domain-transactivating protein 1) (ANT-1) (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein)
Gene: PRPF6

Interactor 2: RNPS1 (Q15287)
RNA-binding protein with serine-rich domain 1 (SR-related protein LDC2)
Gene: RNPS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.621

Property	Details
Experiments	26496610, 17353931
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0008380 - RNA splicing and 1 others more... GO:0016607 - nuclear speck
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 941 Hs			1 305
+	Hs
		300288 PRP6_HUMAN (1-941): 0: 610: 100.00		PPIE_HUMAN (159-297): 4.41e-33: 125: 17.73
+	Hs
		300087 PRP6_HUMAN (1-941): 0: 610: 100.00		NCBP2_HUMAN (128-271): 1.08e-30: 114: 18.06
+	Sc
		586448 PRP6_YEAST (4-924): 7.58e-80: 280: 21.50		NCBP2_YEAST (127-236): 1.25e-33: 124: 25.46
+	Hs
		1070619 CRNL1_HUMAN (521-932): 8.54e-41: 164: 12.50		RNPS1_HUMAN (1-234): 2e-34: 128: 100.00
+	Hs
		1318165 CRNL1_HUMAN (521-932): 8.54e-41: 164: 12.50		PPIE_HUMAN (159-297): 4.41e-33: 125: 17.73
+	Sc
		996591 CLF1_YEAST (444-939): 6.13e-37: 150: 13.17		NCBP2_YEAST (127-236): 1.25e-33: 124: 25.46
+	Hs
		1070651 SYF1_HUMAN (109-527): 1.77e-12: 73.4: 13.78		RNPS1_HUMAN (1-234): 2e-34: 128: 100.00
+	Hs
		1336499 SYF1_HUMAN (109-527): 1.77e-12: 73.4: 13.78		PPIE_HUMAN (159-297): 4.41e-33: 125: 17.73
+	Sc
		982907 RRP5_YEAST (276-524): 4.45e-12: 72.5: 17.28		NCBP2_YEAST (127-236): 1.25e-33: 124: 25.46
+	Hs
		174907 OGT1_HUMAN (120-352): 4.99e-10: 65.7: 11.39		RNPS1_HUMAN (1-234): 2e-34: 128: 100.00
+	Dm
		54167 SYF1_DROME (229-527): 1.98e-12: 73.4: 15.24		PPIE_DROME (157-291): 2.07e-31: 120: 18.52
+	Hs
		174461 OGT1_HUMAN (120-352): 4.99e-10: 65.7: 11.39		RFOX2_HUMAN (44-274): 2.32e-31: 122: 13.25
+	Mm
		665754 CTR9_MOUSE (126-536): 5.01e-16: 85.3: 10.12		PABP1_MOUSE (65-252): 1.7e-21: 96.5: 16.32
+	Ce
		954283 P91175_CAEEL (111-561): 3.29e-12: 72.6: 12.15		Q9U2S6_CAEEL (156-263): 5.51e-20: 90.4: 20.37
+	Hs
		174583 OGT1_HUMAN (120-352): 4.99e-10: 65.7: 11.39		PABP1_HUMAN (65-252): 1.33e-21: 96.9: 16.32
+	Hs
		174849 OGT1_HUMAN (120-352): 4.99e-10: 65.7: 11.39		PABP4_HUMAN (153-248): 4.98e-19: 89.2: 27.08