HitPredict

Interactor 1: DIRA1 (O95057)
GTP-binding protein Di-Ras1 (Distinct subgroup of the Ras family member 1) (Ras-related inhibitor of cell growth) (Rig) (Small GTP-binding tumor suppressor 1)
Gene: DIRAS1

Interactor 2: GDS1 (P52306)
Rap1 GTPase-GDP dissociation stimulator 1 (Exchange factor smgGDS) (SMG GDS protein) (SMG P21 stimulatory GDP/GTP exchange protein)
Gene: RAP1GDS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.80	0.806

Property	Details
Experiments	28514442, 32296183, 33961781, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, validated two hybrid, anti tag coimmunoprecipitation, two hybrid array, two hybrid prey pooling approach
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Arm~Ras
Common GO terms	-
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 198 Hs			1 607
+	Hs
		854121 DIRA2_HUMAN (1-198): 1.16e-81: 242: 78.89		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		854133 RAB1B_HUMAN (2-196): 2.09e-79: 236: 28.86		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		318087 DIRA3_HUMAN (7-198): 1.85e-49: 161: 46.63		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		854088 RAP1A_HUMAN (7-171): 2.93e-43: 144: 43.71		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		854082 RAP1B_HUMAN (7-171): 6.61e-43: 143: 43.11		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		854120 RHES_HUMAN (6-167): 3.71e-39: 136: 44.19		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		854083 RAP2B_HUMAN (7-165): 8.55e-39: 133: 48.75		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		854154 RAP2C_HUMAN (7-165): 1.44e-38: 132: 50.63		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		486015 RAP2A_HUMAN (7-165): 5.28e-35: 123: 50.00		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		488066 RRAS_HUMAN (5-165): 1.24e-31: 115: 41.98		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		506444 RALB_HUMAN (8-198): 1.08e-31: 115: 34.38		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Xl
		292764 RALBB_XENLA (8-198): 1.63e-31: 115: 34.38		GDS1A_XENLA (1-607): 0: 899: 85.50
+	Xl
		292765 RALBA_XENLA (8-198): 1.45e-31: 115: 34.38		GDS1A_XENLA (1-607): 0: 899: 85.50
+	Dm
		51787 O96692_DROME (7-171): 2.23e-37: 129: 45.61		GDS1_DROME (62-536): 0: 540: 31.27