HitPredict

Interactor 1: UBR5 (O95071)
E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)
Gene: UBR5

Interactor 2: NEST (P48681)
Nestin
Gene: NES

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2799 Hs			1 1621
+	Hs
		304001 UBR5_HUMAN (1-2799): 0: 3949: 100.00		VIME_HUMAN (8-343): 3.05e-118: 382: 28.32
+	Hs
		304318 UBR5_HUMAN (1-2799): 0: 3949: 100.00		CP250_HUMAN (48-1491): 3.97e-42: 172: 11.11
+	Hs
		304418 UBR5_HUMAN (1-2799): 0: 3949: 100.00		MYH4_HUMAN (17-755): 1.14e-23: 111: 10.41
+	Hs
		443826 SMUF1_HUMAN (2357-2796): 2.47e-141: 463: 21.18		VIME_HUMAN (8-343): 3.05e-118: 382: 28.32
+	Hs
		443533 UBE3C_HUMAN (2301-2796): 5.2e-128: 435: 20.33		VIME_HUMAN (8-343): 3.05e-118: 382: 28.32
+	Hs
		280825 SMUF1_HUMAN (2357-2796): 2.47e-141: 463: 21.18		KRT36_HUMAN (6-313): 8.66e-80: 273: 20.56
+	Mm
		1160055 HUWE1_MOUSE (2499-2798): 9.29e-101: 367: 27.27		NEST_MOUSE (1-1409): 2.88e-55: 215: 41.82
+	Hs
		1061257 SMUF1_HUMAN (2357-2796): 2.47e-141: 463: 21.18		NUMA1_HUMAN (818-1473): 5.43e-19: 96.5: 10.02
+	Hs
		724841 UBE3C_HUMAN (2301-2796): 5.2e-128: 435: 20.33		MYH9_HUMAN (729-1459): 1.22e-24: 115: 10.48
+	Hs
		422458 SMUF1_HUMAN (2357-2796): 2.47e-141: 463: 21.18		NFM_HUMAN (8-333): 4.76e-14: 79.7: 26.21
+	Hs
		1192196 HUWE1_HUMAN (2499-2798): 1.29e-100: 366: 27.27		CP250_HUMAN (48-1491): 3.97e-42: 172: 11.11
+	Hs
		125464 WWP2_HUMAN (2430-2797): 2.93e-130: 435: 20.94		NUMA1_HUMAN (818-1473): 5.43e-19: 96.5: 10.02
+	Hs
		569126 SMUF2_HUMAN (2405-2796): 3.89e-134: 442: 22.36		DESM_HUMAN (8-316): 2.1e-14: 79.7: 25.47
+	Hs
		724896 HUWE1_HUMAN (2499-2798): 1.29e-100: 366: 27.27		MYH9_HUMAN (729-1459): 1.22e-24: 115: 10.48
+	Hs
		444535 UBE3A_HUMAN (2529-2799): 7.88e-20: 99.4: 29.93		K2C7_HUMAN (7-321): 7.48e-118: 381: 24.70
+	Hs
		531556 UBE3A_HUMAN (2529-2799): 7.88e-20: 99.4: 29.93		K2C5_HUMAN (7-319): 3.83e-86: 296: 20.56
+	Hs
		380463 UBE3A_HUMAN (2529-2799): 7.88e-20: 99.4: 29.93		K2C6B_HUMAN (6-332): 2.95e-86: 295: 21.11
+	Hs
		983127 UBE3A_HUMAN (2529-2799): 7.88e-20: 99.4: 29.93		K2C72_HUMAN (6-316): 2.57e-84: 288: 19.12
+	Hs
		724789 UBE3A_HUMAN (2529-2799): 7.88e-20: 99.4: 29.93		MYH9_HUMAN (729-1459): 1.22e-24: 115: 10.48
+	Hs
		535369 UBE3A_HUMAN (2529-2799): 7.88e-20: 99.4: 29.93		GFAP_HUMAN (8-316): 8.2e-22: 102: 30.35