HitPredict

Interactor 1: UBR5 (O95071)
E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)
Gene: UBR5

Interactor 2: SSRP1 (Q08945)
FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160)
Gene: SSRP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	27647897
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006281 - DNA repair
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 2799 Hs			1 709
+	Hs
		304090 UBR5_HUMAN (1-2799): 0: 3949: 100.00		PMS1_HUMAN (400-704): 7.54e-34: 141: 16.23
+	Hs
		304064 UBR5_HUMAN (1-2799): 0: 3949: 100.00		SOX2_HUMAN (516-636): 8.67e-30: 122: 22.31
+	Hs
		996907 SMUF1_HUMAN (2357-2796): 2.47e-141: 463: 21.18		SSRP1_HUMAN (1-709): 0: 805: 100.00
+	Hs
		125410 WWP2_HUMAN (2430-2797): 2.93e-130: 435: 20.94		SSRP1_HUMAN (1-709): 0: 805: 100.00
+	Hs
		1342342 HECW2_HUMAN (2170-2798): 1.03e-139: 482: 19.72		HM20A_HUMAN (460-709): 1.81e-42: 159: 17.20
+	Hs
		818354 ITCH_HUMAN (2187-2797): 8.94e-132: 440: 18.08		SOX2_HUMAN (516-636): 8.67e-30: 122: 22.31
+	Hs
		125241 WWP2_HUMAN (2430-2797): 2.93e-130: 435: 20.94		SOX2_HUMAN (516-636): 8.67e-30: 122: 22.31
+	Hs
		1192175 HUWE1_HUMAN (2499-2798): 1.29e-100: 366: 27.27		CIC_HUMAN (424-708): 7.87e-39: 157: 16.49
+	Hs
		125141 WWP2_HUMAN (2430-2797): 2.93e-130: 435: 20.94		UBF1_HUMAN (416-655): 2.71e-11: 69: 14.52
+	Hs
		297516 HUWE1_HUMAN (2499-2798): 1.29e-100: 366: 27.27		TOX4_HUMAN (484-678): 7.24e-32: 133: 23.86
+	Hs
		643263 NEDD4_HUMAN (2446-2796): 8.62e-120: 416: 23.98		HMGB2_HUMAN (540-698): 5.17e-15: 76.3: 23.53
+	Hs
		70543 NEDD4_HUMAN (2446-2796): 8.62e-120: 416: 23.98		HGB1A_HUMAN (543-634): 1.33e-11: 66.3: 31.92
+	Hs
		449758 HUWE1_HUMAN (2499-2798): 1.29e-100: 366: 27.27		HMGB1_HUMAN (543-634): 1e-14: 75.5: 34.04
+	Hs
		567683 UBE3A_HUMAN (2529-2799): 7.88e-20: 99.4: 29.93		UBF1_HUMAN (416-655): 2.71e-11: 69: 14.52