Protein: CALR3
Calreticulin-3 (Calreticulin-2) (Calsperin)

Gene: CALR3
Organism: Homo sapiens
Interactions: 139
UniProt ID: Q96L12

Gene Ontology (top 5):
GO:0005635 - nuclear envelope
GO:0005788 - endoplasmic reticulum lumen
GO:0005789 - endoplasmic reticulum membrane
GO:0006457 - protein folding
GO:0007283 - spermatogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

452369

PDIA1
Protein disulfide-isomerase

2

20

High-throughput

0.754

High

566803

PDIA4
Protein disulfide-isomerase A4

2

20

High-throughput

0.754

High

697995

CALR
Calreticulin

2

7

High-throughput

0.754

High

699018

CALX
Calnexin

2

7

High-throughput

0.754

High

716218

ERP29
Endoplasmic reticulum resident protein 29

2

20

High-throughput

0.754

High

717574

PDIA3
Protein disulfide-isomerase A3

2

20

High-throughput

0.754

High

1396551

TXD16
Thioredoxin domain-containing protein 16

2

0

High-throughput

0.748

High

1105544

OS9
Protein OS-9

3

1

High-throughput

0.640

High

1175829

T132A
Transmembrane protein 132A

3

0

High-throughput

0.638

High

1396535

ERP44
Endoplasmic reticulum resident protein 44

1

20

High-throughput

0.618

High

922837

ITA8
Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]

2

10

High-throughput

0.611

High

1143661

NOMO1
BOS complex subunit NOMO1

2

1

High-throughput

0.611

High

325985

UBR5
E3 ubiquitin-protein ligase UBR5

3

8

High-throughput

0.609

High

1360637

AGRV1
Adhesion G-protein coupled receptor V1

3

10

High-throughput

0.609

High

229794

CALU
Calumenin

2

10

High-throughput

0.584

High

417682

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

2

4

High-throughput

0.584

High

535418

BIP
Endoplasmic reticulum chaperone BiP

2

4

High-throughput

0.584

High

567056

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

2

3

High-throughput

0.584

High

571499

GLU2B
Glucosidase 2 subunit beta

2

3

High-throughput

0.584

High

573623

ENPL
Endoplasmin

2

5

High-throughput

0.584

High

656221

PPIB
Peptidyl-prolyl cis-trans isomerase B

2

5

High-throughput

0.584

High

813189

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

2

2

High-throughput

0.584

High

880648

LMAN1
Protein ERGIC-53

2

3

High-throughput

0.584

High

888962

TMEDA
Transmembrane emp24 domain-containing protein 10

2

9

High-throughput

0.584

High

895634

SERPH
Serpin H1

2

6

High-throughput

0.584

High

904074

BAP31
B-cell receptor-associated protein 31

2

4

High-throughput

0.584

High

1058596

CKAP4
Cytoskeleton-associated protein 4

2

8

High-throughput

0.584

High

1116905

MOGS
Mannosyl-oligosaccharide glucosidase

2

1

High-throughput

0.584

High

1125035

RCN2
Reticulocalbin-2

2

11

High-throughput

0.584

High

1131354

GANAB
Neutral alpha-glucosidase AB

2

7

High-throughput

0.584

High

1142366

PDIA6
Protein disulfide-isomerase A6

2

20

High-throughput

0.584

High

1145656

RCN1
Reticulocalbin-1

2

10

High-throughput

0.584

High

1146608

TMED2
Transmembrane emp24 domain-containing protein 2

2

9

High-throughput

0.584

High

1258673

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

2

1

High-throughput

0.584

High

1278472

PLGT3
Protein O-glucosyltransferase 3

2

5

High-throughput

0.584

High

1330358

EMC1
ER membrane protein complex subunit 1

2

3

High-throughput

0.584

High

1333539

GT251
Procollagen galactosyltransferase 1

2

8

High-throughput

0.584

High

1334116

TXND5
Thioredoxin domain-containing protein 5

2

20

High-throughput

0.584

High

1349817

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

2

2

High-throughput

0.584

High

1352924

PO210
Nuclear pore membrane glycoprotein 210

2

2

High-throughput

0.584

High

1383761

FKB10
Peptidyl-prolyl cis-trans isomerase FKBP10

2

4

High-throughput

0.584

High

1393113

ERO1A
ERO1-like protein alpha

2

1

High-throughput

0.584

High

1396538

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

2

2

High-throughput

0.584

High

1396540

TMX1
Thioredoxin-related transmembrane protein 1

2

20

High-throughput

0.584

High

1396543

SDF2L
Stromal cell-derived factor 2-like protein 1

2

5

High-throughput

0.584

High

1396549

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

2

10

High-throughput

0.584

High

1396550

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

2

4

High-throughput

0.584

High

1396553

SE1L1
Protein sel-1 homolog 1

2

4

High-throughput

0.584

High

1396562

HYOU1
Hypoxia up-regulated protein 1

2

6

High-throughput

0.584

High

1381327

NCLN
BOS complex subunit NCLN

2

0

High-throughput

0.559

High

284409

CLN5
Bis(monoacylglycero)phosphate synthase CLN5

2

3

High-throughput

0.558

High

554245

BMP4
Bone morphogenetic protein 4

1

6

High-throughput

0.536

High

720522

AMRP
Alpha-2-macroglobulin receptor-associated protein

2

1

High-throughput

0.533

High

1009871

NUCB2
Nucleobindin-2

2

3

High-throughput

0.533

High

1257539

TMTC3
Protein O-mannosyl-transferase TMTC3

2

10

High-throughput

0.533

High

1361347

BRI3B
BRI3-binding protein

2

1

High-throughput

0.533

High

1396534

CAB45
45 kDa calcium-binding protein

2

11

High-throughput

0.533

High

1349920

PNPT1
Polyribonucleotide nucleotidyltransferase 1, mitochondrial

1

0

High-throughput

0.513

High

611296

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

13

High-throughput

0.489

High

1129700

MDC1
Mediator of DNA damage checkpoint protein 1

1

3

High-throughput

0.489

High

1396545

RAB6B
Ras-related protein Rab-6B

1

6

High-throughput

0.489

High

137088

PLOD2
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

1

8

High-throughput

0.479

High

160748

TOR1A
Torsin-1A

1

6

High-throughput

0.479

High

191382

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

3

High-throughput

0.479

High

251109

B4GT3
Beta-1,4-galactosyltransferase 3

1

2

High-throughput

0.479

High

251952

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

1

8

High-throughput

0.479

High

252542

SEP15
Selenoprotein F

1

1

High-throughput

0.479

High

321026

SUN1
SUN domain-containing protein 1

1

1

High-throughput

0.479

High

409472

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

9

High-throughput

0.479

High

462911

LAMB1
Laminin subunit beta-1

1

9

High-throughput

0.479

High

535881

LAMC1
Laminin subunit gamma-1

1

9

High-throughput

0.479

High

651856

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

2

High-throughput

0.479

High

852678

PPIC
Peptidyl-prolyl cis-trans isomerase C

1

5

High-throughput

0.479

High

951360

SC61B
Protein transport protein Sec61 subunit beta

1

3

High-throughput

0.479

High

956097

SPCS3
Signal peptidase complex subunit 3

1

1

High-throughput

0.479

High

1038926

PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

1

8

High-throughput

0.479

High

1038992

NUCB1
Nucleobindin-1

1

3

High-throughput

0.479

High

1086084

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

1

High-throughput

0.479

High

1097029

PRDX4
Peroxiredoxin-4

1

6

High-throughput

0.479

High

1098466

DNJC3
DnaJ homolog subfamily C member 3

1

20

High-throughput

0.479

High

1111664

STIM1
Stromal interaction molecule 1

1

2

High-throughput

0.479

High

1122646

MLEC
Malectin

1

1

High-throughput

0.479

High

1127935

PDIA5
Protein disulfide-isomerase A5

1

20

High-throughput

0.479

High

1131219

MESD
LRP chaperone MESD

1

1

High-throughput

0.479

High

1181420

P3H1
Prolyl 3-hydroxylase 1

1

4

High-throughput

0.479

High

1199239

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

8

High-throughput

0.479

High

1206121

TGO1
Transport and Golgi organization protein 1 homolog

1

4

High-throughput

0.479

High

1206880

TOIP1
Torsin-1A-interacting protein 1

1

4

High-throughput

0.479

High

1211495

FREM2
FRAS1-related extracellular matrix protein 2

1

4

High-throughput

0.479

High

1240559

ERAP2
Endoplasmic reticulum aminopeptidase 2

1

5

High-throughput

0.479

High

1248339

PLGT2
Protein O-glucosyltransferase 2

1

5

High-throughput

0.479

High

1251326

B3GLT
Beta-1,3-glucosyltransferase

1

9

High-throughput

0.479

High

1253788

QSOX2
Sulfhydryl oxidase 2

1

20

High-throughput

0.479

High

1294930

ERO1B
ERO1-like protein beta

1

1

High-throughput

0.479

High

1310015

FXRD2
FAD-dependent oxidoreductase domain-containing protein 2

1

2

High-throughput

0.479

High

1312041

DJC10
DnaJ homolog subfamily C member 10

1

20

High-throughput

0.479

High

1324385

ABD12
Lysophosphatidylserine lipase ABHD12

1

1

High-throughput

0.479

High

1333565

SUMF2
Inactive C-alpha-formylglycine-generating enzyme 2

1

1

High-throughput

0.479

High

1333652

PGLT1
Protein O-glucosyltransferase 1

1

5

High-throughput

0.479

High

1366359

GPI8
GPI-anchor transamidase

1

2

High-throughput

0.479

High

1382152

CCD47
PAT complex subunit CCDC47

1

1

High-throughput

0.479

High

1386177

ASTRA
Protein Aster-A

1

2

High-throughput

0.479

High

1395859

CLP1L
Lipid scramblase CLPTM1L

1

4

High-throughput

0.479

High

1396531

PIGS
GPI-anchor transamidase component PIGS

1

1

High-throughput

0.479

High

1396532

CLCC1
Chloride channel CLIC-like protein 1

1

1

High-throughput

0.479

High

1396536

CNPY3
Protein canopy homolog 3

1

1

High-throughput

0.479

High

1396544

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

3

High-throughput

0.479

High

1396548

DJB12
DnaJ homolog subfamily B member 12

1

11

High-throughput

0.479

High

1396552

DJB11
DnaJ homolog subfamily B member 11

1

3

High-throughput

0.479

High

1396557

NENF
Neudesin

1

2

High-throughput

0.479

High

1396558

MINP1
Multiple inositol polyphosphate phosphatase 1

1

6

High-throughput

0.479

High

1396560

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

3

High-throughput

0.479

High

1380328

MYDGF
Myeloid-derived growth factor

1

0

High-throughput

0.458

High

1396539

SIL1
Nucleotide exchange factor SIL1

1

0

High-throughput

0.458

High

1396542

CC134
Coiled-coil domain-containing protein 134

1

0

High-throughput

0.458

High

431877

ITB1
Integrin beta-1

1

9

High-throughput

0.437

High

520969

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

9

High-throughput

0.437

High

528706

PPGB
Lysosomal protective protein

1

4

High-throughput

0.437

High

648307

ENPP1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

1

8

High-throughput

0.437

High

869954

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

1

High-throughput

0.437

High

1063839

LG3BP
Galectin-3-binding protein

1

5

High-throughput

0.437

High

1127592

FAT1
Protocadherin Fat 1

1

1

High-throughput

0.437

High

1194703

GXLT1
Glucoside xylosyltransferase 1

1

6

High-throughput

0.437

High

1333837

TTC13
Tetratricopeptide repeat protein 13

1

13

High-throughput

0.437

High

1382873

TTC17
Tetratricopeptide repeat protein 17

1

1

High-throughput

0.437

High

1396533

SDF2
Stromal cell-derived factor 2

1

5

High-throughput

0.437

High

1396541

IFG15
Torsin-1A-interacting protein 2, isoform IFRG15

1

1

High-throughput

0.437

High

1396547

ATD3A
ATPase family AAA domain-containing protein 3A

1

6

High-throughput

0.437

High

1396554

SEC63
Translocation protein SEC63 homolog

1

6

High-throughput

0.437

High

1396555

PCYOX
Prenylcysteine oxidase 1

1

4

High-throughput

0.437

High

1396556

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

1

High-throughput

0.437

High

1396559

SRRM2
Serine/arginine repetitive matrix protein 2

1

3

High-throughput

0.437

High

1396546

F217B
Protein FAM217B

3

0

High-throughput

0.347

High

876274

NMU
Neuromedin-U [Cleaved into: Neuromedin precursor-related peptide 36

1

0

High-throughput

0.279

Low

1272723

MAEA
E3 ubiquitin-protein transferase MAEA

1

0

High-throughput

0.279

Low

1327442

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

1

0

High-throughput

0.279

Low

1340268

PLBL2
Putative phospholipase B-like 2

1

0

High-throughput

0.249

Low

1396537

CHID1
Chitinase domain-containing protein 1

1

0

High-throughput

0.249

Low

1396561

CNPY2
Protein canopy homolog 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025