HitPredict

Interactor 1: VAMP5 (O95183)
Vesicle-associated membrane protein 5 (VAMP-5) (Myobrevin)
Gene: VAMP5

Interactor 2: VAMP7 (P51809)
Vesicle-associated membrane protein 7 (VAMP-7) (Synaptobrevin-like protein 1) (Tetanus-insensitive VAMP) (Ti-VAMP)
Gene: VAMP7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Longin~Synaptobrevin, Synaptobrevin~Synaptobrevin
Common GO terms	GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 116 Hs			1 220
+	Hs
		850543 VAMP7_HUMAN (4-96): 5.88e-26: 98: 31.18		VAMP7_HUMAN (1-220): 3.87e-90: 266: 100.00
+	Hs
		850567 VAMP3_HUMAN (2-72): 2.01e-24: 90.7: 38.03		VAMP7_HUMAN (1-220): 3.87e-90: 266: 100.00
+	Hs
		263123 VAMP5_HUMAN (1-116): 2.4e-35: 118: 100.00		SC22B_HUMAN (23-206): 4.4e-59: 186: 22.16
+	Hs
		180776 VAMP5_HUMAN (1-116): 2.4e-35: 118: 100.00		YKT6_HUMAN (23-179): 3.99e-55: 176: 23.42
+	Dm
		115809 Q7JYX5_DROME (4-96): 1.36e-32: 114: 31.18		M9PGI6_DROME (24-204): 2.11e-53: 172: 26.23
+	Dm
		1178144 Q7JYX5_DROME (4-96): 1.36e-32: 114: 31.18		Q9W3M8_DROME (5-179): 4.42e-51: 165: 21.02
+	Dm
		115796 SYB_DROME (2-88): 9.74e-30: 105: 39.08		M9PGI6_DROME (24-204): 2.11e-53: 172: 26.23
+	Dm
		577266 SYB_DROME (2-88): 9.74e-30: 105: 39.08		Q9W3M8_DROME (5-179): 4.42e-51: 165: 21.02
+	Sc
		731090 NYV1_YEAST (9-81): 2.24e-21: 86.9: 21.92		YKT6_YEAST (5-179): 3.71e-52: 168: 22.73
+	Sc
		605833 SNC2_YEAST (2-74): 6.15e-24: 90: 23.29		SEC22_YEAST (37-206): 4.98e-49: 161: 20.93
+	Sc
		605883 NYV1_YEAST (9-81): 2.24e-21: 86.9: 21.92		SEC22_YEAST (37-206): 4.98e-49: 161: 20.93
+	Dm
		577225 Q7JYX5_DROME (4-96): 1.36e-32: 114: 31.18		SYB_DROME (99-215): 1.35e-32: 116: 26.50
+	Hs
		306857 VAMP5_HUMAN (1-116): 2.4e-35: 118: 100.00		VAMP8_HUMAN (114-193): 3.49e-13: 65.1: 41.25
+	Hs
		926250 VAMP2_HUMAN (2-75): 2.33e-25: 93.8: 39.19		VAMP8_HUMAN (114-193): 3.49e-13: 65.1: 41.25
+	Hs
		1079421 VAMP3_HUMAN (2-72): 2.01e-24: 90.7: 38.03		VAMP8_HUMAN (114-193): 3.49e-13: 65.1: 41.25
+	Sc
		678141 SNC1_YEAST (2-72): 1.48e-23: 89.2: 21.13		SNC1_YEAST (125-191): 1.39e-09: 55.8: 41.79