HitPredict

Interactor 1: ARI2 (O95376)
E3 ubiquitin-protein ligase ARIH2 (ARI-2) (Protein ariadne-2 homolog) (EC 2.3.2.31) (RING-type E3 ubiquitin transferase ARIH2) (Triad1 protein)
Gene: ARIH2

Interactor 2: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31253590
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 493 Hs			1 551
+	Hs
		312519 ARI2_HUMAN (1-493): 0: 546: 100.00		SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98
+	Hs
		312462 ARI2_HUMAN (1-493): 0: 546: 100.00		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		312672 ARI2_HUMAN (1-493): 0: 546: 100.00		OGFR_HUMAN (170-417): 4.4e-09: 61.1: 21.76
+	Hs
		302333 ARI1_HUMAN (55-492): 4.1e-167: 485: 34.44		SC31A_HUMAN (127-488): 4.72e-28: 121: 14.25
+	Hs
		1031383 CUL9_HUMAN (64-465): 3.89e-125: 404: 25.37		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Hs
		1084567 RNF31_HUMAN (104-374): 5.18e-60: 215: 19.72		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		227586 PRKN_HUMAN (113-330): 7.77e-52: 184: 22.93		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		226905 PRKN_HUMAN (113-330): 7.77e-52: 184: 22.93		SMCA2_HUMAN (179-551): 2.13e-47: 180: 14.93
+	Hs
		228053 PRKN_HUMAN (113-330): 7.77e-52: 184: 22.93		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		516636 RNF31_HUMAN (104-374): 5.18e-60: 215: 19.72		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		227354 PRKN_HUMAN (113-330): 7.77e-52: 184: 22.93		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Hs
		226120 PRKN_HUMAN (113-330): 7.77e-52: 184: 22.93		SC31A_HUMAN (127-488): 4.72e-28: 121: 14.25
+	Hs
		226375 PRKN_HUMAN (113-330): 7.77e-52: 184: 22.93		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		228678 PRKN_HUMAN (113-330): 7.77e-52: 184: 22.93		PABP3_HUMAN (82-518): 1.28e-22: 103: 15.56
+	Hs
		227642 PRKN_HUMAN (113-330): 7.77e-52: 184: 22.93		PAP1L_HUMAN (81-485): 1.03e-19: 94.6: 12.53
+	Hs
		229228 PRKN_HUMAN (113-330): 7.77e-52: 184: 22.93		PCLO_HUMAN (131-447): 2.08e-14: 78.8: 12.23
+	Hs
		226957 PRKN_HUMAN (113-330): 7.77e-52: 184: 22.93		SC24C_HUMAN (233-440): 1.79e-12: 72.2: 17.05
+	Hs
		228623 PRKN_HUMAN (113-330): 7.77e-52: 184: 22.93		WDR33_HUMAN (180-396): 5.21e-09: 61.5: 24.69
+	Hs
		228928 PRKN_HUMAN (113-330): 7.77e-52: 184: 22.93		OGFR_HUMAN (170-417): 4.4e-09: 61.1: 21.76