HitPredict

Interactor 1: BAG4 (O95429)
BAG family molecular chaperone regulator 4 (BAG-4) (Bcl-2-associated athanogene 4) (Silencer of death domains)
Gene: BAG4

Interactor 2: Q53FC7 (Q53FC7)
Heat shock 70kDa protein 6 (HSP70B') variant
Gene: Q53FC7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25036637
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	BAG~HSP70
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 457 Hs			1 643
+	Hs
		314001 BAG4_HUMAN (1-457): 0: 698: 100.00		HSP76_HUMAN (1-643): 0: 990: 99.22
+	Hs
		314010 BAG4_HUMAN (1-457): 0: 698: 100.00		HS71L_HUMAN (1-643): 0: 981: 78.85
+	Hs
		313996 BAG4_HUMAN (1-457): 0: 698: 100.00		HSP7C_HUMAN (4-615): 0: 959: 78.76
+	Hs
		314025 BAG4_HUMAN (1-457): 0: 698: 100.00		HSP72_HUMAN (3-643): 0: 945: 77.14
+	Mm
		571864 BAG4_MOUSE (1-457): 0: 611: 82.79		HS71B_MOUSE (5-643): 0: 960: 80.31
+	Hs
		324216 BAG3_HUMAN (354-457): 1.21e-22: 102: 47.12		HSP76_HUMAN (1-643): 0: 990: 99.22
+	Hs
		324435 BAG3_HUMAN (354-457): 1.21e-22: 102: 47.12		Q53FC7_HUMAN (1-643): 0: 985: 100.00
+	Dm
		65607 A8JNS4_DROME (352-456): 6.34e-29: 121: 40.74		HSP72_DROME (7-643): 0: 965: 70.67
+	Hs
		324256 BAG3_HUMAN (354-457): 1.21e-22: 102: 47.12		HS71L_HUMAN (1-643): 0: 981: 78.85
+	Hs
		564206 BAG5_HUMAN (370-456): 3.04e-16: 82.5: 41.38		HSP76_HUMAN (1-643): 0: 990: 99.22
+	Dm
		505107 Q9VU81_DROME (352-456): 4.39e-29: 122: 40.74		HSP7D_DROME (4-614): 0: 945: 78.89
+	Mm
		571868 BAG3_MOUSE (350-457): 8.44e-24: 106: 45.95		HS71B_MOUSE (5-643): 0: 960: 80.31
+	Dm
		65601 A8JNS4_DROME (352-456): 6.34e-29: 121: 40.74		HSP7D_DROME (4-614): 0: 945: 78.89
+	Mm
		926166 BAG3_MOUSE (350-457): 8.44e-24: 106: 45.95		HSP7C_MOUSE (4-615): 0: 958: 78.76
+	Hs
		324195 BAG3_HUMAN (354-457): 1.21e-22: 102: 47.12		HSP7C_HUMAN (4-615): 0: 959: 78.76
+	Hs
		324190 BAG3_HUMAN (354-457): 1.21e-22: 102: 47.12		HS71A_HUMAN (5-643): 0: 954: 81.85
+	Hs
		324298 BAG3_HUMAN (354-457): 1.21e-22: 102: 47.12		HSP72_HUMAN (3-643): 0: 945: 77.14
+	Mm
		571863 BAG5_MOUSE (370-456): 1.45e-16: 83.6: 40.23		HS71B_MOUSE (5-643): 0: 960: 80.31
+	Mm
		926151 BAG5_MOUSE (370-456): 1.45e-16: 83.6: 40.23		HSP7C_MOUSE (4-615): 0: 958: 78.76
+	Hs
		504937 BAG5_HUMAN (370-456): 3.04e-16: 82.5: 41.38		HSP7C_HUMAN (4-615): 0: 959: 78.76