HitPredict

Interactor 1: FMNL1 (O95466)
Formin-like protein 1 (CLL-associated antigen KW-13) (Leukocyte formin)
Gene: FMNL1

Interactor 2: RHOU (Q7L0Q8)
Rho-related GTP-binding protein RhoU (CDC42-like GTPase 1) (GTP-binding protein-like 1) (Rho GTPase-like protein ARHU) (Ryu GTPase) (Wnt-1 responsive Cdc42 homolog 1) (WRCH-1)
Gene: RHOU

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Drf_FH3~Ras, Drf_GBD~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0008360 - regulation of cell shape
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1100 Hs			1 258
+	Hs
		436466 FMNL2_HUMAN (1-1097): 0: 834: 57.31		RHOC_HUMAN (51-231): 3.2e-89: 264: 46.96
+	Hs
		314860 FMNL1_HUMAN (1-1100): 0: 849: 100.00		RHOG_HUMAN (48-233): 5.28e-83: 248: 48.93
+	Hs
		314858 FMNL1_HUMAN (1-1100): 0: 849: 100.00		RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76
+	Hs
		314855 FMNL1_HUMAN (1-1100): 0: 849: 100.00		RB11A_HUMAN (39-256): 1.13e-77: 235: 26.87
+	Hs
		314854 FMNL1_HUMAN (1-1100): 0: 849: 100.00		RHOA_HUMAN (51-232): 1.24e-77: 234: 46.15
+	Hs
		314838 FMNL1_HUMAN (1-1100): 0: 849: 100.00		RAC2_HUMAN (50-233): 5.11e-77: 233: 56.52
+	Hs
		314853 FMNL1_HUMAN (1-1100): 0: 849: 100.00		CDC42_HUMAN (50-236): 2.23e-74: 226: 58.82
+	Hs
		925531 FMNL2_HUMAN (1-1097): 0: 834: 57.31		RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76
+	Hs
		900815 FMNL2_HUMAN (1-1097): 0: 834: 57.31		RHOA_HUMAN (51-232): 1.24e-77: 234: 46.15
+	Hs
		894328 FMNL2_HUMAN (1-1097): 0: 834: 57.31		CDC42_HUMAN (50-236): 2.23e-74: 226: 58.82
+	Hs
		314890 FMNL1_HUMAN (1-1100): 0: 849: 100.00		RHOJ_HUMAN (40-238): 2.64e-63: 199: 51.26
+	Dm
		776921 FRL_DROME (19-1088): 0: 650: 36.85		RAC1_DROME (48-234): 3.68e-84: 251: 54.55
+	Dm
		776944 FRL_DROME (19-1088): 0: 650: 36.85		CDC42_DROME (50-233): 8.32e-73: 222: 57.61
+	Hs
		925768 FHOD1_HUMAN (185-1099): 1.49e-138: 449: 16.22		RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76
+	Hs
		894633 FHOD1_HUMAN (185-1099): 1.49e-138: 449: 16.22		CDC42_HUMAN (50-236): 2.23e-74: 226: 58.82
+	Hs
		436333 INF2_HUMAN (181-1063): 2.53e-120: 402: 20.27		RHOC_HUMAN (51-231): 3.2e-89: 264: 46.96
+	Hs
		900661 FMNL3_HUMAN (1-506): 6.36e-130: 423: 60.90		RHOA_HUMAN (51-232): 1.24e-77: 234: 46.15
+	Hs
		545484 FMNL3_HUMAN (1-506): 6.36e-130: 423: 60.90		RAC2_HUMAN (50-233): 5.11e-77: 233: 56.52
+	Hs
		894190 FMNL3_HUMAN (1-506): 6.36e-130: 423: 60.90		CDC42_HUMAN (50-236): 2.23e-74: 226: 58.82
+	Hs
		545409 INF2_HUMAN (181-1063): 2.53e-120: 402: 20.27		RAC2_HUMAN (50-233): 5.11e-77: 233: 56.52