HitPredict

Interactor 1: ABCA1 (O95477)
Phospholipid-transporting ATPase ABCA1 (EC 7.6.2.1) (ATP-binding cassette sub-family A member 1) (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1) (Cholesterol efflux regulatory protein)
Gene: ABCA1

Interactor 2: APOA1 (P02647)
Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I (Apolipoprotein A-I(1-242))]
Gene: APOA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.79 0.60 0.692

The method score is based on:

Property Details
Experiments 27017521, 12084722, 22271762, 30458687
Identification Methods affinity chromatography technology, pull down, anti tag coimmunoprecipitation, cross-linking study
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005102 - signaling receptor binding
GO:0005886 - plasma membrane
GO:0007186 - G protein-coupled receptor signaling pathway
GO:0008035 - high-density lipoprotein particle binding
GO:0008203 - cholesterol metabolic process
and 12 others

more...
Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 2261
Hs

1 267
+ Hs
+ Hs

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Last updated: 15 Jul 2024