Protein: WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]

Gene: WRN
Organism: Homo sapiens
Interactions: 107
UniProt ID: Q14191

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0000400 - four-way junction DNA binding
GO:0000403 - Y-form DNA binding
GO:0000405 - bubble DNA binding
GO:0000723 - telomere maintenance

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1062455

DHX9
ATP-dependent RNA helicase A

2

20

Small-scale

0.799

High

926355

BLM
RecQ-like DNA helicase BLM

1

19

Small-scale

0.761

High

558124

XRCC6
X-ray repair cross-complementing protein 6

10

14

Small-scale

0.760

High

559352

XRCC5
X-ray repair cross-complementing protein 5

8

14

Small-scale

0.758

High

695436

RFA1
Replication protein A 70 kDa DNA-binding subunit

10

13

Small-scale

0.753

High

1122936

MIB1
E3 ubiquitin-protein ligase MIB1

1

7

Small-scale

0.747

High

588676

RFA2
Replication protein A 32 kDa subunit

6

13

Small-scale

0.732

High

1122924

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

1

16

Small-scale

0.724

High

814524

FEN1
Flap endonuclease 1

4

2

Small-scale

0.717

High

768170

RFA3
Replication protein A 14 kDa subunit

5

8

Small-scale

0.709

High

1122940

WDR48
WD repeat-containing protein 48

1

20

High-throughput

0.691

High

551042

PCNA
Proliferating cell nuclear antigen

4

6

Small-scale

0.683

High

413818

P53
Cellular tumor antigen p53

3

6

Small-scale

0.676

High

1122935

SKAP1
Src kinase-associated phosphoprotein 1

3

17

High-throughput

0.667

High

799103

BRCA1
Breast cancer type 1 susceptibility protein

3

20

Small-scale

0.664

High

1122947

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

7

Small-scale

0.659

High

855441

ATRX
Transcriptional regulator ATRX

1

20

Small-scale

0.647

High

1122952

BARD1
BRCA1-associated RING domain protein 1

1

7

Small-scale

0.647

High

1122967

RA54B
DNA repair and recombination protein RAD54B

1

20

Small-scale

0.647

High

487302

PARP1
Poly [ADP-ribose] polymerase 1

2

12

Small-scale

0.646

High

1122929

TERF2
Telomeric repeat-binding factor 2

2

4

Small-scale

0.641

High

1055912

RAD51
DNA repair protein RAD51 homolog 1

2

14

Small-scale

0.634

High

1109444

ATR
Serine/threonine-protein kinase ATR

3

11

Small-scale

0.631

High

847993

RAD52
DNA repair protein RAD52 homolog

2

0

Small-scale

0.628

High

180288

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

4

Small-scale

0.618

High

352434

TOP3B
DNA topoisomerase 3-beta-1

1

11

High-throughput

0.618

High

807415

IF4A3
Eukaryotic initiation factor 4A-III

1

19

High-throughput

0.618

High

937244

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

20

High-throughput

0.618

High

1008719

RED1
Double-stranded RNA-specific editase 1

1

19

High-throughput

0.618

High

1089651

ILF3
Interleukin enhancer-binding factor 3

1

20

High-throughput

0.618

High

1122925

DHX8
ATP-dependent RNA helicase DHX8

1

18

High-throughput

0.618

High

1122934

TRI69
E3 ubiquitin-protein ligase TRIM69

1

5

Small-scale

0.618

High

1122939

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.618

High

1122945

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

20

High-throughput

0.618

High

1122946

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

20

High-throughput

0.618

High

1008141

PRKDC
DNA-dependent protein kinase catalytic subunit

2

10

Small-scale

0.613

High

934598

TERA
Transitional endoplasmic reticulum ATPase

2

9

Small-scale

0.601

High

262077

NBN
Nibrin

2

4

Small-scale

0.584

High

591643

H2AX
Histone H2AX

1

8

Small-scale

0.578

High

1028197

MDM2
E3 ubiquitin-protein ligase Mdm2

1

4

Small-scale

0.578

High

1122954

PAXX
Protein PAXX

2

0

High-throughput

0.576

High

1122949

WRIP1
ATPase WRNIP1

1

4

Small-scale

0.573

High

396096

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

842755

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

3

Small-scale

0.561

High

1094673

CAF1A
Chromatin assembly factor 1 subunit A

1

5

Small-scale

0.561

High

1122964

HECD1
E3 ubiquitin-protein ligase HECTD1

1

17

High-throughput

0.553

High

253203

RAD1
Cell cycle checkpoint protein RAD1

1

0

Small-scale

0.537

High

1122951

RAD9A
Cell cycle checkpoint control protein RAD9A

1

0

Small-scale

0.537

High

391251

FRIL
Ferritin light chain

1

1

High-throughput

0.536

High

783150

ARL3
ADP-ribosylation factor-like protein 3

1

5

High-throughput

0.536

High

853253

CBX5
Chromobox protein homolog 5

1

11

Small-scale

0.536

High

1122944

CBP
CREB-binding protein

1

11

Small-scale

0.536

High

1122963

DPOLL
DNA polymerase lambda

1

1

High-throughput

0.536

High

1102160

ATM
Serine-protein kinase ATM

1

10

Small-scale

0.516

High

1122941

CTBL1
Beta-catenin-like protein 1

1

2

High-throughput

0.515

High

1122948

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.513

High

1122953

TINF2
TERF1-interacting nuclear factor 2

1

0

High-throughput

0.513

High

446527

DPOLB
DNA polymerase beta

1

1

Small-scale

0.501

High

216436

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

3

Small-scale

0.500

High

837612

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

6

Small-scale

0.500

High

1122960

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

3

High-throughput

0.489

High

964276

SUMO2
Small ubiquitin-related modifier 2

1

10

Small-scale

0.481

High

991323

SUMO1
Small ubiquitin-related modifier 1

1

10

Small-scale

0.481

High

1122961

POLK
DNA polymerase kappa

1

0

Small-scale

0.480

High

188884

TMPS2
Transmembrane protease serine 2

1

1

High-throughput

0.479

High

317175

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

4

Small-scale

0.479

High

342868

HERC2
E3 ubiquitin-protein ligase HERC2

1

15

Small-scale

0.479

High

400823

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.479

High

411916

NTRK1
High affinity nerve growth factor receptor

1

8

High-throughput

0.479

High

507960

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

7

Small-scale

0.479

High

714111

PML
Protein PML

1

20

Small-scale

0.479

High

851764

NKX21
Homeobox protein Nkx-2.1

1

8

High-throughput

0.479

High

872315

SOX2
Transcription factor SOX-2

1

14

High-throughput

0.479

High

879080

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

18

High-throughput

0.479

High

955160

CDC42
Cell division control protein 42 homolog

1

11

High-throughput

0.479

High

979640

H4
Histone H4

1

8

High-throughput

0.479

High

984759

RL31
Large ribosomal subunit protein eL31

1

6

High-throughput

0.479

High

1016849

H33
Histone H3.3

1

17

High-throughput

0.479

High

1024572

VIGLN
Vigilin

1

20

High-throughput

0.479

High

1083355

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

5

High-throughput

0.479

High

1109715

HDAC1
Histone deacetylase 1

1

17

Small-scale

0.479

High

1113084

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1122927

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.479

High

1122928

EEA1
Early endosome antigen 1

1

9

High-throughput

0.479

High

1122932

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

4

Small-scale

0.479

High

1122933

SHLD2
Shieldin complex subunit 2

1

2

High-throughput

0.479

High

1122937

SLX4
Structure-specific endonuclease subunit SLX4

1

13

High-throughput

0.479

High

1122942

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

1

High-throughput

0.479

High

1122943

HDAC2
Histone deacetylase 2

1

17

Small-scale

0.479

High

1122950

CDC5L
Cell division cycle 5-like protein

1

7

Small-scale

0.479

High

1122955

MOV10
Helicase MOV-10

1

10

High-throughput

0.479

High

1122957

ARL8B
ADP-ribosylation factor-like protein 8B

1

3

High-throughput

0.479

High

1122958

NALP2
NACHT, LRR and PYD domains-containing protein 2

1

6

Small-scale

0.479

High

1122962

NXF1
Nuclear RNA export factor 1

1

4

High-throughput

0.479

High

1122966

SP16H
FACT complex subunit SPT16

1

3

High-throughput

0.479

High

459287

CATL1
Procathepsin L

1

0

High-throughput

0.458

High

143434

E2F3
Transcription factor E2F3

1

3

Small-scale

0.445

High

1122938

DTX3
Probable E3 ubiquitin-protein ligase DTX3

1

2

High-throughput

0.445

High

1122959

GRHL1
Grainyhead-like protein 1 homolog

1

5

High-throughput

0.445

High

1122931

LRC31
Leucine-rich repeat-containing protein 31

1

7

High-throughput

0.437

High

654110

XPA
DNA repair protein complementing XP-A cells

1

0

High-throughput

0.426

High

892563

DNLI3
DNA ligase 3

1

0

High-throughput

0.426

High

1122956

RN146
E3 ubiquitin-protein ligase RNF146

1

0

Small-scale

0.426

High

1122926

MDC1
Mediator of DNA damage checkpoint protein 1

1

19

Small-scale

0.408

High

1122930

K0930
Uncharacterized protein KIAA0930

4

0

High-throughput

0.360

High

1122965

CLC4E
C-type lectin domain family 4 member E

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025