HitPredict

Interactor 1: CXL14 (O95715)
C-X-C motif chemokine 14 (Chemokine BRAK) (MIP-2G) (Small-inducible cytokine B14)
Gene: CXCL14

Interactor 2: PLF4 (P02776)
Platelet factor 4 (PF-4) (C-X-C motif chemokine 4) (Iroplact) (Oncostatin-A) [Cleaved into: Platelet factor 4, short form (Endothelial cell growth inhibitor)]
Gene: PF4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.51	1.00	0.716

Property	Details
Experiments	28381538
Identification Methods	pull down, filter binding, surface plasmon resonance
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	IL8~IL8
Common GO terms	GO:0005615 - extracellular space GO:0008009 - chemokine activity GO:0061844 - antimicrobial humoral immune response mediated by antimicrobial peptide
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 111 Hs			1 101
+	Hs
		320091 CXL14_HUMAN (1-111): 2.98e-72: 211: 100.00		CXCL5_HUMAN (21-100): 1.55e-29: 103: 41.25
+	Hs
		320080 CXL14_HUMAN (1-111): 2.98e-72: 211: 100.00		CXCL7_HUMAN (26-99): 4.02e-28: 100: 50.00
+	Hs
		320086 CXL14_HUMAN (1-111): 2.98e-72: 211: 100.00		CXCL2_HUMAN (30-101): 1.79e-28: 100: 41.67
+	Hs
		320082 CXL14_HUMAN (1-111): 2.98e-72: 211: 100.00		CXL10_HUMAN (17-98): 1.58e-21: 82.8: 26.19
+	Hs
		320099 CXL14_HUMAN (1-111): 2.98e-72: 211: 100.00		CXCL9_HUMAN (31-97): 3.46e-21: 82.8: 27.94
+	Hs
		150302 CXL14_HUMAN (1-111): 2.98e-72: 211: 100.00		CXL11_HUMAN (17-98): 4.33e-21: 81.6: 22.62