Protein: PLMN
Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B]

Gene: PLMN, PLG
Organism: Homo sapiens
Interactions: 88
UniProt ID: P00747

Gene Ontology (top 5):
GO:0002020 - protease binding
GO:0004175 - endopeptidase activity
GO:0004252 - serine-type endopeptidase activity
GO:0005102 - signaling receptor binding
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

366321

SPRC
SPARC

2

2

Small-scale

0.799

High

366318

A2AP
Alpha-2-antiplasmin

2

20

Small-scale

0.778

High

366338

CRK
Adapter molecule crk

1

1

High-throughput

0.691

High

366317

MET
Hepatocyte growth factor receptor

1

20

Small-scale

0.665

High

366271

FA10
Coagulation factor X

1

14

Small-scale

0.647

High

366305

APOH
Beta-2-glycoprotein 1

1

5

Small-scale

0.647

High

366310

A4
Amyloid-beta precursor protein

1

17

Small-scale

0.647

High

366311

PAI1
Plasminogen activator inhibitor 1

1

20

Small-scale

0.647

High

366323

CO7
Complement component C7

1

8

Small-scale

0.647

High

366347

PAPP1
Pappalysin-1

1

14

Small-scale

0.647

High

366350

PCOC1
Procollagen C-endopeptidase enhancer 1

1

12

Small-scale

0.647

High

366326

TF
Tissue factor

1

0

Small-scale

0.614

High

366316

TSP1
Thrombospondin-1

2

16

Small-scale

0.602

High

366332

1433T
14-3-3 protein theta

2

3

High-throughput

0.601

High

366304

IGHA1
Immunoglobulin heavy constant alpha 1

1

1

High-throughput

0.575

High

366368

CBPB2
Carboxypeptidase B2

1

4

Small-scale

0.575

High

366330

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

1

Small-scale

0.561

High

366339

ACTB
Actin, cytoplasmic 1

1

0

Small-scale

0.554

High

366354

AMOT
Angiomotin

1

1

Small-scale

0.552

High

366328

IBP3
Insulin-like growth factor-binding protein 3

1

2

Small-scale

0.550

High

366309

HSPB1
Heat shock protein beta-1

1

1

Small-scale

0.536

High

194432

P2RX6
P2X purinoceptor 6

1

1

High-throughput

0.536

High

366327

AATC
Aspartate aminotransferase, cytoplasmic

1

1

High-throughput

0.536

High

366335

CCR1
C-C chemokine receptor type 1

1

3

High-throughput

0.536

High

366364

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

4

High-throughput

0.536

High

366374

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

2

High-throughput

0.536

High

366325

CH60
60 kDa heat shock protein, mitochondrial

1

0

Small-scale

0.531

High

366379

RHG20
Rho GTPase-activating protein 20

2

7

High-throughput

0.521

High

366383

RHG26
Rho GTPase-activating protein 26

2

3

High-throughput

0.521

High

366333

LYOX
Protein-lysine 6-oxidase

1

0

Small-scale

0.513

High

366334

SC6A1
Sodium- and chloride-dependent GABA transporter 1

1

0

High-throughput

0.513

High

366363

RHBL4
Rhomboid-related protein 4

1

0

High-throughput

0.513

High

366381

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

0

High-throughput

0.513

High

366322

RAP2A
Ras-related protein Rap-2a

1

2

High-throughput

0.508

High

366303

KNG1
Kininogen-1

1

1

Small-scale

0.501

High

366306

FINC
Fibronectin

1

9

Small-scale

0.501

High

366315

HS90A
Heat shock protein HSP 90-alpha

1

1

Small-scale

0.501

High

366319

HMGB1
High mobility group protein B1

1

2

Small-scale

0.501

High

366329

LAMA1
Laminin subunit alpha-1

1

5

Small-scale

0.501

High

366340

S10AA
Protein S100-A10

1

3

Small-scale

0.501

High

366352

LAMA3
Laminin subunit alpha-3

1

11

Small-scale

0.501

High

366337

DPP6
A-type potassium channel modulatory protein DPP6

1

0

High-throughput

0.493

High

366343

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

1

High-throughput

0.489

High

366357

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

5

High-throughput

0.489

High

366373

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

5

High-throughput

0.489

High

366384

SSUH2
Protein SSUH2 homolog

1

1

High-throughput

0.489

High

366336

SYUA
Alpha-synuclein

1

3

High-throughput

0.481

High

366342

SMAD3
Mothers against decapentaplegic homolog 3

1

2

High-throughput

0.481

High

366348

SMAD4
Mothers against decapentaplegic homolog 4

1

2

High-throughput

0.481

High

366351

MK14
Mitogen-activated protein kinase 14

1

1

High-throughput

0.481

High

366369

YTDC1
YTH domain-containing protein 1

1

3

High-throughput

0.481

High

366313

ENOA
Alpha-enolase

1

0

Small-scale

0.480

High

366324

CMGA
Chromogranin-A

1

0

Small-scale

0.480

High

366377

PLRKT
Plasminogen receptor

1

0

Small-scale

0.480

High

240433

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.479

High

366307

MYCN
N-myc proto-oncogene protein

1

8

High-throughput

0.479

High

366308

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

366312

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

1

Small-scale

0.479

High

366314

ANXA2
Annexin A2

1

1

Small-scale

0.479

High

366331

PTX3
Pentraxin-related protein PTX3

1

3

Small-scale

0.479

High

366344

TF65
Transcription factor p65

1

1

Small-scale

0.479

High

366356

RHG21
Rho GTPase-activating protein 21

1

2

High-throughput

0.479

High

366359

CDC73
Parafibromin

1

1

High-throughput

0.479

High

366360

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

366376

RGAP1
Rac GTPase-activating protein 1

1

3

High-throughput

0.479

High

366353

FX4L6
Forkhead box protein D4-like 6

1

1

High-throughput

0.470

High

366346

PRDX4
Peroxiredoxin-4

1

0

High-throughput

0.460

High

366366

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

0

High-throughput

0.460

High

366320

F16P1
Fructose-1,6-bisphosphatase 1

1

0

High-throughput

0.458

High

366362

MALD2
MARVEL domain-containing protein 2

1

2

Small-scale

0.457

High

366358

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.445

High

319271

UFL1
E3 UFM1-protein ligase 1

1

4

High-throughput

0.437

High

366341

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.437

High

366367

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.437

High

366371

RING2
E3 ubiquitin-protein ligase RING2

1

3

High-throughput

0.437

High

366375

TRI31
E3 ubiquitin-protein ligase TRIM31

1

5

High-throughput

0.437

High

366382

PKHG1
Pleckstrin homology domain-containing family G member 1

1

2

High-throughput

0.437

High

261038

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.426

High

366372

THIOM
Thioredoxin, mitochondrial

1

2

High-throughput

0.417

High

366355

Q5JYA6
PLEKHG1

1

2

High-throughput

0.407

High

282644

E2F6
Transcription factor E2F6

1

0

High-throughput

0.279

Low

366365

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.279

Low

366378

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.279

Low

366380

PHF11
PHD finger protein 11

1

0

High-throughput

0.279

Low

366361

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

0

High-throughput

0.265

Low

366345

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.251

Low

366349

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.249

Low

366370

MYCBP
c-Myc-binding protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025