HitPredict

Interactor 1: CXL14 (O95715)
C-X-C motif chemokine 14 (Chemokine BRAK) (MIP-2G) (Small-inducible cytokine B14)
Gene: CXCL14

Interactor 2: CCL5 (P13501)
C-C motif chemokine 5 (EoCP) (Eosinophil chemotactic cytokine) (SIS-delta) (Small-inducible cytokine A5) (T cell-specific protein P228) (TCP228) (T-cell-specific protein RANTES) [Cleaved into: RANTES(3-68); RANTES(4-68)]
Gene: CCL5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.51	1.00	0.716

Property	Details
Experiments	28381538
Identification Methods	pull down, surface plasmon resonance, filter binding
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	IL8~IL8
Common GO terms	GO:0005615 - extracellular space GO:0006935 - chemotaxis GO:0007267 - cell-cell signaling GO:0008009 - chemokine activity
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 111 Hs			1 91
+	Hs
		320109 CXL14_HUMAN (1-111): 2.98e-72: 211: 100.00		CCL13_HUMAN (1-90): 5.7e-36: 118: 31.87
+	Hs
		320095 CXL14_HUMAN (1-111): 2.98e-72: 211: 100.00		CCL11_HUMAN (1-90): 8.16e-28: 98.1: 41.76
+	Hs
		320115 CXL14_HUMAN (1-111): 2.98e-72: 211: 100.00		CCL26_HUMAN (21-89): 8.09e-25: 90.8: 40.58
+	Hs
		320105 CXL14_HUMAN (1-111): 2.98e-72: 211: 100.00		CCL17_HUMAN (1-89): 3.41e-23: 86.5: 28.09
+	Hs
		320092 CXL14_HUMAN (1-111): 2.98e-72: 211: 100.00		XCL1_HUMAN (1-90): 3.92e-22: 84.2: 33.33
+	Hs
		134280 CXL14_HUMAN (1-111): 2.98e-72: 211: 100.00		CCL21_HUMAN (23-91): 1.24e-18: 76.1: 28.77