Protein: PSD10
26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) (p28(GANK))

Gene: PSD10, PSMD10
Organism: Homo sapiens
Interactions: 138
UniProt ID: O75832

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000502 - proteasome complex
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

295468

PRS6B
26S proteasome regulatory subunit 6B

15

9

Small-scale

0.989

High

295483

PRS8
26S proteasome regulatory subunit 8

9

10

Small-scale

0.973

High

295482

PRS4
26S proteasome regulatory subunit 4

7

9

Small-scale

0.962

High

295462

PRS7
26S proteasome regulatory subunit 7

7

7

Small-scale

0.958

High

295453

PRS6A
26S proteasome regulatory subunit 6A

6

18

Small-scale

0.941

High

295485

PRS10
26S proteasome regulatory subunit 10B

4

11

Small-scale

0.896

High

295493

UBE3A
Ubiquitin-protein ligase E3A

3

15

Small-scale

0.847

High

295450

CDK4
Cyclin-dependent kinase 4

2

5

Small-scale

0.821

High

295492

TF65
Transcription factor p65

2

8

Small-scale

0.806

High

295545

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

2

19

Small-scale

0.789

High

128112

PSD12
26S proteasome non-ATPase regulatory subunit 12

8

3

Small-scale

0.749

High

295555

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

8

14

Small-scale

0.749

High

137887

PSDE
26S proteasome non-ATPase regulatory subunit 14

8

8

Small-scale

0.749

High

295474

PSMD7
26S proteasome non-ATPase regulatory subunit 7

6

8

High-throughput

0.734

High

221990

NCK2
Cytoplasmic protein NCK2

1

20

Small-scale

0.724

High

295454

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

19

Small-scale

0.724

High

295478

PSMD4
26S proteasome non-ATPase regulatory subunit 4

5

2

Small-scale

0.716

High

295490

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

8

Small-scale

0.715

High

295504

ADRM1
Proteasomal ubiquitin receptor ADRM1

5

1

High-throughput

0.712

High

127842

PSD11
26S proteasome non-ATPase regulatory subunit 11

5

3

Small-scale

0.712

High

295502

PSMD6
26S proteasome non-ATPase regulatory subunit 6

5

4

Small-scale

0.712

High

295529

PSMD1
26S proteasome non-ATPase regulatory subunit 1

5

4

Small-scale

0.712

High

295534

PAAF1
Proteasomal ATPase-associated factor 1

5

12

Small-scale

0.712

High

295496

PSMD2
26S proteasome non-ATPase regulatory subunit 2

4

4

High-throughput

0.694

High

295439

HERC2
E3 ubiquitin-protein ligase HERC2

1

14

High-throughput

0.691

High

295452

PTN2
Tyrosine-protein phosphatase non-receptor type 2

4

10

High-throughput

0.691

High

295552

PSD13
26S proteasome non-ATPase regulatory subunit 13

4

2

Small-scale

0.687

High

295444

RB
Retinoblastoma-associated protein

4

2

Small-scale

0.686

High

295488

MDM2
E3 ubiquitin-protein ligase Mdm2

3

3

Small-scale

0.680

High

210818

PSMD3
26S proteasome non-ATPase regulatory subunit 3

3

2

High-throughput

0.671

High

295516

LDB1
LIM domain-binding protein 1

1

0

High-throughput

0.663

High

295476

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

3

6

Small-scale

0.656

High

240310

PRKN
E3 ubiquitin-protein ligase parkin

3

4

Small-scale

0.640

High

295508

CCD92
Coiled-coil domain-containing protein 92

3

0

High-throughput

0.638

High

295505

PSMD5
26S proteasome non-ATPase regulatory subunit 5

3

0

High-throughput

0.634

High

295471

PSMD8
26S proteasome non-ATPase regulatory subunit 8

2

1

High-throughput

0.628

High

131630

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

10

Small-scale

0.618

High

295443

P53
Cellular tumor antigen p53

1

9

Small-scale

0.618

High

295464

CCNF
Cyclin-F

1

8

High-throughput

0.618

High

295481

RHOA
Transforming protein RhoA

1

20

Small-scale

0.618

High

295497

DUS8
Dual specificity protein phosphatase 8

1

9

High-throughput

0.618

High

295498

CUL3
Cullin-3

1

15

High-throughput

0.618

High

295500

KEAP1
Kelch-like ECH-associated protein 1

1

1

Small-scale

0.618

High

295513

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

295532

DUS9
Dual specificity protein phosphatase 9

1

8

High-throughput

0.618

High

295551

DUS12
Dual specificity protein phosphatase 12

1

9

High-throughput

0.618

High

295528

CC74B
Coiled-coil domain-containing protein 74B

3

1

High-throughput

0.609

High

295479

SEM1
26S proteasome complex subunit SEM1

3

0

Small-scale

0.597

High

131095

CLIC1
Chloride intracellular channel protein 1

1

1

Small-scale

0.597

High

295495

GRSF1
G-rich sequence factor 1

1

2

Small-scale

0.597

High

295447

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

4

High-throughput

0.595

High

295467

MAGA4
Melanoma-associated antigen 4

1

13

Small-scale

0.586

High

295494

EP300
Histone acetyltransferase p300

2

12

Small-scale

0.584

High

295556

SERC
Phosphoserine aminotransferase

2

0

High-throughput

0.583

High

295451

KCRB
Creatine kinase B-type

1

1

High-throughput

0.575

High

295473

RAB7A
Ras-related protein Rab-7a

1

12

High-throughput

0.575

High

295510

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

8

High-throughput

0.575

High

295472

CEBPA
CCAAT/enhancer-binding protein alpha

2

5

Small-scale

0.563

High

295448

HS71A
Heat shock 70 kDa protein 1A

1

12

Small-scale

0.561

High

295461

HSP74
Heat shock 70 kDa protein 4

1

16

Small-scale

0.561

High

128362

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

2

High-throughput

0.536

High

161583

RGPD8
RANBP2-like and GRIP domain-containing protein 8

1

7

High-throughput

0.536

High

295446

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

2

High-throughput

0.536

High

295449

TAU
Microtubule-associated protein tau

1

13

High-throughput

0.536

High

295530

RGPD5
RANBP2-like and GRIP domain-containing protein 5/6

1

7

High-throughput

0.536

High

295531

BAG1
BAG family molecular chaperone regulator 1

1

2

High-throughput

0.536

High

295549

MED23
Mediator of RNA polymerase II transcription subunit 23

1

1

High-throughput

0.536

High

295435

DDAH1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

1

0

Small-scale

0.530

High

249701

DOK2
Docking protein 2

1

5

High-throughput

0.515

High

295486

H2B1C
Histone H2B type 1-C/E/F/G/I

1

5

High-throughput

0.515

High

295540

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.513

High

295458

CCND2
G1/S-specific cyclin-D2

1

2

Small-scale

0.501

High

295459

AGTR1
Type-1 angiotensin II receptor

1

6

High-throughput

0.494

High

295525

CC74A
Coiled-coil domain-containing protein 74A

1

1

High-throughput

0.489

High

279247

TULP3
Tubby-related protein 3

1

2

High-throughput

0.479

High

292947

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

295437

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

295438

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

2

Small-scale

0.479

High

295445

HS90A
Heat shock protein HSP 90-alpha

1

14

Small-scale

0.479

High

295455

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

1

High-throughput

0.479

High

295465

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

Small-scale

0.479

High

295469

YAP1
Transcriptional coactivator YAP1

1

20

Small-scale

0.479

High

295475

GDIR1
Rho GDP-dissociation inhibitor 1

1

2

Small-scale

0.479

High

295477

RD23B
UV excision repair protein RAD23 homolog B

1

5

High-throughput

0.479

High

295484

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

7

High-throughput

0.479

High

295489

PO5F1
POU domain, class 5, transcription factor 1

1

7

Small-scale

0.479

High

295499

TRI14
Tripartite motif-containing protein 14

1

13

High-throughput

0.479

High

295501

BECN1
Beclin-1

1

1

Small-scale

0.479

High

295506

HIF1A
Hypoxia-inducible factor 1-alpha

1

2

Small-scale

0.479

High

295507

CL16A
Protein CLEC16A

1

2

High-throughput

0.479

High

295511

DDI2
Protein DDI1 homolog 2

1

5

High-throughput

0.479

High

295515

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

12

High-throughput

0.479

High

295518

RN149
E3 ubiquitin-protein ligase RNF149

1

4

High-throughput

0.479

High

295519

SERB1
SERPINE1 mRNA-binding protein 1

1

3

High-throughput

0.479

High

295520

ZFN2B
AN1-type zinc finger protein 2B

1

1

High-throughput

0.479

High

295521

UBCP1
Ubiquitin-like domain-containing CTD phosphatase 1

1

3

Small-scale

0.479

High

295522

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

14

High-throughput

0.479

High

295523

CBP
CREB-binding protein

1

10

Small-scale

0.479

High

295524

CELF1
CUGBP Elav-like family member 1

1

6

Small-scale

0.479

High

295527

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

295537

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

12

Small-scale

0.479

High

295539

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

295547

ZRAN1
Ubiquitin thioesterase ZRANB1

1

12

High-throughput

0.479

High

295548

XPO7
Exportin-7

1

11

High-throughput

0.479

High

295554

RNF11
RING finger protein 11

1

6

Small-scale

0.479

High

295436

ATG12
Ubiquitin-like protein ATG12

1

0

Small-scale

0.458

High

295456

NFYA
Nuclear transcription factor Y subunit alpha

1

0

Small-scale

0.458

High

295457

NFYB
Nuclear transcription factor Y subunit beta

1

0

Small-scale

0.458

High

295487

HSF1
Heat shock factor protein 1

1

0

Small-scale

0.458

High

295514

SEML
Putative protein SEM1, isoform 2

1

0

High-throughput

0.458

High

295526

RITA1
RBPJ-interacting and tubulin-associated protein 1

1

0

Small-scale

0.458

High

295538

ATG5
Autophagy protein 5

1

0

Small-scale

0.458

High

58776

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

2

High-throughput

0.445

High

226641

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

16

High-throughput

0.445

High

295440

GSHR
Glutathione reductase, mitochondrial

1

2

High-throughput

0.445

High

295463

CAPG
Macrophage-capping protein

1

14

High-throughput

0.445

High

295480

UBC12
NEDD8-conjugating enzyme Ubc12

1

6

High-throughput

0.445

High

295491

AKA12
A-kinase anchor protein 12

1

11

High-throughput

0.445

High

295503

ABRX2
BRISC complex subunit Abraxas 2

1

1

Small-scale

0.445

High

295512

PDE12
2',5'-phosphodiesterase 12

1

2

High-throughput

0.445

High

295550

UBQL1
Ubiquilin-1

1

7

High-throughput

0.445

High

295441

PNPH
Purine nucleoside phosphorylase

1

0

High-throughput

0.426

High

295442

CAH2
Carbonic anhydrase 2

1

0

High-throughput

0.426

High

295470

MAOX
NADP-dependent malic enzyme

1

0

High-throughput

0.426

High

295544

S39A9
Zinc transporter ZIP9

1

0

High-throughput

0.426

High

680

A0A087WW66
26S proteasome non-ATPase regulatory subunit 1

1

4

High-throughput

0.407

High

295460

ILEU
Leukocyte elastase inhibitor

1

7

High-throughput

0.407

High

295466

CNDD3
Condensin-2 complex subunit D3

1

2

High-throughput

0.407

High

295517

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

7

High-throughput

0.407

High

295533

SOST
Sclerostin

1

3

High-throughput

0.407

High

295536

ZDHC5
Palmitoyltransferase ZDHHC5

1

5

High-throughput

0.407

High

295543

S22AB
Solute carrier family 22 member 11

1

4

High-throughput

0.407

High

295553

XCT
Cystine/glutamate transporter

1

3

High-throughput

0.407

High

295509

TMM31
Transmembrane protein 31

2

0

High-throughput

0.313

High

295535

ELOV1
Very long chain fatty acid elongase 1

1

0

High-throughput

0.269

Low

295541

GRPE1
GrpE protein homolog 1, mitochondrial

1

0

High-throughput

0.232

Low

295542

GLOD4
Glyoxalase domain-containing protein 4

1

0

High-throughput

0.232

Low

295546

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025