HitPredict

Interactor 1: OXSR1 (O95747)
Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein)
Gene: OXSR1

Interactor 2: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding GO:0035556 - intracellular signal transduction GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 527 Hs			1 192
+	Hs
		925702 STK39_HUMAN (10-527): 1.74e-152: 448: 73.75		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		901015 STK39_HUMAN (10-527): 1.74e-152: 448: 73.75		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		647868 MARK3_HUMAN (5-513): 5.55e-130: 397: 19.25		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		564418 MARK3_HUMAN (5-513): 5.55e-130: 397: 19.25		RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67
+	Hs
		925384 MARK2_HUMAN (3-517): 2.86e-128: 394: 18.49		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		564584 MARK2_HUMAN (3-517): 2.86e-128: 394: 18.49		RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67
+	Hs
		545213 MARK3_HUMAN (5-513): 5.55e-130: 397: 19.25		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		545461 MARK2_HUMAN (3-517): 2.86e-128: 394: 18.49		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		647958 MARK3_HUMAN (5-513): 5.55e-130: 397: 19.25		RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64
+	Hs
		1183120 MARK2_HUMAN (3-517): 2.86e-128: 394: 18.49		RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64
+	Hs
		647855 MARK3_HUMAN (5-513): 5.55e-130: 397: 19.25		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19
+	Hs
		647872 MARK3_HUMAN (5-513): 5.55e-130: 397: 19.25		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		647856 MARK3_HUMAN (5-513): 5.55e-130: 397: 19.25		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		892447 MARK2_HUMAN (3-517): 2.86e-128: 394: 18.49		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19
+	Hs
		951102 MARK2_HUMAN (3-517): 2.86e-128: 394: 18.49		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		894157 MARK2_HUMAN (3-517): 2.86e-128: 394: 18.49		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		647858 MARK3_HUMAN (5-513): 5.55e-130: 397: 19.25		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		900617 MARK2_HUMAN (3-517): 2.86e-128: 394: 18.49		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		436165 MARK3_HUMAN (5-513): 5.55e-130: 397: 19.25		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45
+	Hs
		436371 MARK2_HUMAN (3-517): 2.86e-128: 394: 18.49		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45