Protein: TM63B
Mechanosensitive cation channel TMEM63B (Transmembrane protein 63B) (hTMEM63B)

Gene: TM63B, TMEM63B
Organism: Homo sapiens
Interactions: 168
UniProt ID: Q5T3F8

Gene Ontology (top 5):
GO:0005227 - calcium-activated cation channel activity
GO:0005765 - lysosomal membrane
GO:0005886 - plasma membrane
GO:0006887 - exocytosis
GO:0007605 - sensory perception of sound

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

320459

TM63A
Mechanosensitive cation channel TMEM63A

1

6

High-throughput

0.691

High

1212317

TM63C
Osmosensitive cation channel TMEM63C

1

6

High-throughput

0.691

High

956896

CXCR4
C-X-C chemokine receptor type 4

3

5

High-throughput

0.662

High

1212258

S39A4
Zinc transporter ZIP4

4

0

High-throughput

0.661

High

1036207

NRG1
Pro-neuregulin-1, membrane-bound isoform

3

0

High-throughput

0.638

High

845513

PI2R
Prostacyclin receptor

2

1

High-throughput

0.628

High

1032591

AT2B2
Plasma membrane calcium-transporting ATPase 2

2

3

High-throughput

0.628

High

1180848

S4A8
Electroneutral sodium bicarbonate exchanger 1

2

2

High-throughput

0.628

High

1212263

TPRA1
Transmembrane protein adipocyte-associated 1

2

1

High-throughput

0.628

High

1212299

YIPF3
Protein YIPF3

2

1

High-throughput

0.628

High

1212323

PCDGG
Protocadherin gamma-B4

2

3

High-throughput

0.628

High

1212326

VPP2
V-type proton ATPase 116 kDa subunit a 2

2

3

High-throughput

0.628

High

1212328

PCDA3
Protocadherin alpha-3

2

2

High-throughput

0.628

High

127348

LEG8
Galectin-8

3

6

High-throughput

0.609

High

878035

AGRE5
Adhesion G protein-coupled receptor E5

2

0

High-throughput

0.602

High

1212290

GPR21
Probable G-protein coupled receptor 21

2

0

High-throughput

0.602

High

1212310

I17RB
Interleukin-17 receptor B

2

0

High-throughput

0.602

High

256049

S19A2
Thiamine transporter 1

2

1

High-throughput

0.601

High

1212294

ZNT2
Proton-coupled zinc antiporter SLC30A2

2

5

High-throughput

0.601

High

337105

NPT2B
Sodium-dependent phosphate transport protein 2B

2

0

High-throughput

0.576

High

1212312

SCN3B
Sodium channel regulatory subunit beta-3

2

0

High-throughput

0.576

High

1205814

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

1

High-throughput

0.574

High

1126301

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

2

1

High-throughput

0.549

High

183936

S22A2
Solute carrier family 22 member 2

1

1

High-throughput

0.536

High

248472

O10H2
Olfactory receptor 10H2

1

1

High-throughput

0.536

High

276318

HMMR
Hyaluronan mediated motility receptor

1

1

High-throughput

0.536

High

276839

VATG1
V-type proton ATPase subunit G 1

1

1

High-throughput

0.536

High

299231

FLOT1
Flotillin-1

1

1

High-throughput

0.536

High

321261

ERLN2
Erlin-2

1

3

High-throughput

0.536

High

349438

TSN15
Tetraspanin-15

1

2

High-throughput

0.536

High

376612

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

1

High-throughput

0.536

High

388129

ACHA
Acetylcholine receptor subunit alpha

1

2

High-throughput

0.536

High

420565

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

2

High-throughput

0.536

High

443821

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

2

High-throughput

0.536

High

575661

GPIX
Platelet glycoprotein IX

1

1

High-throughput

0.536

High

598107

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

2

High-throughput

0.536

High

609702

LEG3
Galectin-3

1

6

High-throughput

0.536

High

618388

TSN8
Tetraspanin-8

1

2

High-throughput

0.536

High

627349

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

4

High-throughput

0.536

High

637025

VATB2
V-type proton ATPase subunit B, brain isoform

1

1

High-throughput

0.536

High

640396

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

5

High-throughput

0.536

High

669003

FPR2
N-formyl peptide receptor 2

1

7

High-throughput

0.536

High

680384

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

2

High-throughput

0.536

High

766622

PHB1
Prohibitin 1

1

1

High-throughput

0.536

High

800501

VATA
V-type proton ATPase catalytic subunit A

1

3

High-throughput

0.536

High

851131

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

1

High-throughput

0.536

High

936063

PAR2
Proteinase-activated receptor 2

1

3

High-throughput

0.536

High

961529

VA0D1
V-type proton ATPase subunit d 1

1

1

High-throughput

0.536

High

1031800

LAT1
Large neutral amino acids transporter small subunit 1

1

1

High-throughput

0.536

High

1124829

FLOT2
Flotillin-2

1

1

High-throughput

0.536

High

1195433

NKAI1
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

1

1

High-throughput

0.536

High

1203677

TTMP
TPA-induced transmembrane protein

1

1

High-throughput

0.536

High

1212256

CAVN1
Caveolae-associated protein 1

1

1

High-throughput

0.536

High

1212266

M4A15
Membrane-spanning 4-domains subfamily A member 15

1

2

High-throughput

0.536

High

1212268

SIDT2
SID1 transmembrane family member 2

1

1

High-throughput

0.536

High

1212274

S38A5
Sodium-coupled neutral amino acid transporter 5

1

1

High-throughput

0.536

High

1212282

TSN17
Tetraspanin-17

1

2

High-throughput

0.536

High

1212287

S38A2
Sodium-coupled neutral amino acid symporter 2

1

1

High-throughput

0.536

High

1212289

PHB2
Prohibitin-2

1

1

High-throughput

0.536

High

1212295

YIPF4
Protein YIPF4

1

2

High-throughput

0.536

High

1212301

TTYH1
Protein tweety homolog 1

1

1

High-throughput

0.536

High

1212304

LPAR2
Lysophosphatidic acid receptor 2

1

2

High-throughput

0.536

High

1212305

RXFP1
Relaxin receptor 1

1

2

High-throughput

0.536

High

1212311

M4A12
Membrane-spanning 4-domains subfamily A member 12

1

2

High-throughput

0.536

High

1212318

PCD10
Protocadherin-10

1

3

High-throughput

0.536

High

1212327

PCDGL
Protocadherin gamma-C4

1

3

High-throughput

0.536

High

125020

KCNK1
Potassium channel subfamily K member 1

1

0

High-throughput

0.513

High

400964

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.513

High

520876

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

0

High-throughput

0.513

High

590298

MUC1
Mucin-1

1

0

High-throughput

0.513

High

595058

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

0

High-throughput

0.513

High

716031

GNA11
Guanine nucleotide-binding protein subunit alpha-11

1

0

High-throughput

0.513

High

771776

SCN4A
Sodium channel protein type 4 subunit alpha

1

0

High-throughput

0.513

High

852772

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

0

High-throughput

0.513

High

869888

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

0

High-throughput

0.513

High

878319

MRP
MARCKS-related protein

1

0

High-throughput

0.513

High

907797

CLCN7
H(+)/Cl(-) exchange transporter 7

1

0

High-throughput

0.513

High

1058457

CKAP4
Cytoskeleton-associated protein 4

1

0

High-throughput

0.513

High

1102795

UT1
Urea transporter 1

1

0

High-throughput

0.513

High

1105617

GOGA4
Golgin subfamily A member 4

1

0

High-throughput

0.513

High

1153250

AAAT
Neutral amino acid transporter B(0)

1

0

High-throughput

0.513

High

1212253

TM268
Transmembrane protein 268

1

0

High-throughput

0.513

High

1212259

LRC55
Leucine-rich repeat-containing protein 55

1

0

High-throughput

0.513

High

1212265

S35F6
Solute carrier family 35 member F6

1

0

High-throughput

0.513

High

1212272

SPP2B
Signal peptide peptidase-like 2B

1

0

High-throughput

0.513

High

1212298

SGPP1
Sphingosine-1-phosphate phosphatase 1

1

0

High-throughput

0.513

High

1212302

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.513

High

1212308

TMM9B
Transmembrane protein 9B

1

0

High-throughput

0.513

High

1212309

TLR9
Toll-like receptor 9

1

0

High-throughput

0.513

High

1212314

MYOF
Myoferlin

1

0

High-throughput

0.513

High

1212315

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.513

High

125491

LEG9
Galectin-9

1

6

High-throughput

0.489

High

165591

SCAM3
Secretory carrier-associated membrane protein 3

1

1

High-throughput

0.489

High

283274

ERLN1
Erlin-1

1

1

High-throughput

0.489

High

889123

RBM25
RNA-binding protein 25

1

1

High-throughput

0.489

High

1212277

CAVN3
Caveolae-associated protein 3

1

1

High-throughput

0.489

High

1212278

YIPF5
Protein YIPF5

1

2

High-throughput

0.489

High

1212279

SARAF
Store-operated calcium entry-associated regulatory factor

1

2

High-throughput

0.489

High

1212283

ZDH12
Palmitoyltransferase ZDHHC12

1

3

High-throughput

0.489

High

1212285

S35E1
Solute carrier family 35 member E1

1

1

High-throughput

0.489

High

1212292

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

1

High-throughput

0.489

High

1212300

DERL2
Derlin-2

1

1

High-throughput

0.489

High

1212322

TMCO1
Calcium load-activated calcium channel

1

1

High-throughput

0.489

High

1041109

CAV1
Caveolin-1

1

1

High-throughput

0.479

High

1141663

EEA1
Early endosome antigen 1

1

0

High-throughput

0.458

High

1154099

ITSN1
Intersectin-1

1

0

High-throughput

0.458

High

1212261

TCPR1
Tectonin beta-propeller repeat-containing protein 1

1

0

High-throughput

0.458

High

704019

5HT1E
5-hydroxytryptamine receptor 1E

1

1

High-throughput

0.445

High

834980

S19A1
Reduced folate transporter

1

1

High-throughput

0.445

High

886068

CXCR3
C-X-C chemokine receptor type 3

1

5

High-throughput

0.445

High

1212254

MFSD5
Molybdate-anion transporter

1

1

High-throughput

0.445

High

1212273

MOT10
Monocarboxylate transporter 10

1

2

High-throughput

0.445

High

1212307

SO1B3
Solute carrier organic anion transporter family member 1B3

1

1

High-throughput

0.445

High

1212313

GPC5B
G-protein coupled receptor family C group 5 member B

1

1

High-throughput

0.445

High

940608

ATP5E
ATP synthase F(1) complex subunit epsilon, mitochondrial

1

1

High-throughput

0.437

High

1212262

PABP2
Polyadenylate-binding protein 2

1

1

High-throughput

0.437

High

1212264

SL9A9
Sodium/hydrogen exchanger 9

1

0

High-throughput

0.426

High

1212291

SC6A7
Sodium-dependent proline transporter

1

0

High-throughput

0.426

High

1212306

ANKH
Mineralization regulator ANKH

1

0

High-throughput

0.426

High

1212325

FLVC2
Choline/ethanolamine transporter FLVCR2

1

0

High-throughput

0.426

High

91722

C9JKI3
Caveolin

1

1

High-throughput

0.407

High

108078

G3V4T2
Polyadenylate-binding protein 2

1

1

High-throughput

0.407

High

1212252

AT5EL
ATP synthase subunit epsilon-like protein, mitochondrial

1

1

High-throughput

0.407

High

1212255

NIPA3
Magnesium transporter NIPA3

1

1

High-throughput

0.407

High

1212257

NPAL3
NIPA-like protein 3

1

1

High-throughput

0.407

High

1212269

ZNT7
Zinc transporter 7

1

5

High-throughput

0.407

High

1212303

IPPK
Inositol-pentakisphosphate 2-kinase

2

0

High-throughput

0.328

High

123117

DX39A
ATP-dependent RNA helicase DDX39A

1

0

High-throughput

0.279

Low

280656

PR40A
Pre-mRNA-processing factor 40 homolog A

1

0

High-throughput

0.279

Low

298727

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

1

0

High-throughput

0.279

Low

348544

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

0

High-throughput

0.279

Low

417487

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.279

Low

634477

LMNB1
Lamin-B1

1

0

High-throughput

0.279

Low

701838

ABCD3
ATP-binding cassette sub-family D member 3

1

0

High-throughput

0.279

Low

773899

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.279

Low

837657

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.279

Low

894802

EMD
Emerin

1

0

High-throughput

0.279

Low

925933

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

0

High-throughput

0.279

Low

940662

ATP5I
ATP synthase F(0) complex subunit e, mitochondrial

1

0

High-throughput

0.279

Low

1043132

TAP1
Antigen peptide transporter 1

1

0

High-throughput

0.279

Low

1063784

LG3BP
Galectin-3-binding protein

1

0

High-throughput

0.279

Low

1151130

OASL
2'-5'-oligoadenylate synthase-like protein

1

0

High-throughput

0.279

Low

1204970

RABL3
Rab-like protein 3

1

0

High-throughput

0.279

Low

1207322

PCID2
PCI domain-containing protein 2

1

0

High-throughput

0.279

Low

1212270

T185A
Transmembrane protein 185A

1

0

High-throughput

0.279

Low

1212276

TNPO1
Transportin-1

1

0

High-throughput

0.279

Low

1212280

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

0

High-throughput

0.279

Low

1212286

DIESL
DGAT1/2-independent enzyme synthesizing storage lipids

1

0

High-throughput

0.279

Low

1212288

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

0

High-throughput

0.279

Low

1212293

APOL2
Apolipoprotein L2

1

0

High-throughput

0.279

Low

1212296

RCAF1
GEL complex subunit OPTI

1

0

High-throughput

0.279

Low

1212297

TM109
Voltage-gated monoatomic cation channel TMEM109

1

0

High-throughput

0.279

Low

1212316

ORML1
ORM1-like protein 1

1

0

High-throughput

0.279

Low

1212319

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

0

High-throughput

0.279

Low

1212320

ENOPH
Enolase-phosphatase E1

1

0

High-throughput

0.279

Low

1212321

TBD
Tubulin delta chain

1

0

High-throughput

0.279

Low

1212324

MAGD2
Melanoma-associated antigen D2

1

0

High-throughput

0.279

Low

1212329

SRPRB
Signal recognition particle receptor subunit beta

1

0

High-throughput

0.279

Low

1158112

MK14
Mitogen-activated protein kinase 14

1

0

High-throughput

0.251

Low

413984

P53
Cellular tumor antigen p53

1

0

High-throughput

0.249

Low

1212284

RSRC1
Serine/Arginine-related protein 53

1

0

High-throughput

0.249

Low

170800

CLGN
Calmegin

1

0

High-throughput

0.232

Low

469495

SYPH
Synaptophysin

1

0

High-throughput

0.232

Low

1212260

DPH6
Diphthine--ammonia ligase

1

0

High-throughput

0.232

Low

1212267

S43A3
Equilibrative nucleobase transporter 1

1

0

High-throughput

0.232

Low

1212271

TBC15
TBC1 domain family member 15

1

0

High-throughput

0.232

Low

1212275

TM171
Transmembrane protein 171

1

0

High-throughput

0.232

Low

1212281

SAAL1
Protein SAAL1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025