Protein: TM63A
Mechanosensitive cation channel TMEM63A (Transmembrane protein 63A) (hTMEM63A)

Gene: TM63A, TMEM63A
Organism: Homo sapiens
Interactions: 114
UniProt ID: O94886

Gene Ontology (top 5):
GO:0003676 - nucleic acid binding
GO:0005227 - calcium-activated cation channel activity
GO:0005765 - lysosomal membrane
GO:0005886 - plasma membrane
GO:0007040 - lysosome organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

320459

TM63B
Mechanosensitive cation channel TMEM63B

1

6

High-throughput

0.691

High

320512

TM63C
Osmosensitive cation channel TMEM63C

1

6

High-throughput

0.691

High

320428

LEG3
Galectin-3

3

6

High-throughput

0.667

High

158744

AP3D1
AP-3 complex subunit delta-1

3

1

High-throughput

0.662

High

320481

AP3S1
AP-3 complex subunit sigma-1

3

2

High-throughput

0.662

High

320452

EREP1
Endosomal transmembrane epsin interactor 1

3

0

High-throughput

0.638

High

320436

PI2R
Prostacyclin receptor

2

1

High-throughput

0.628

High

320438

5HT3A
5-hydroxytryptamine receptor 3A

2

3

High-throughput

0.628

High

320442

BI1
Bax inhibitor 1

2

1

High-throughput

0.628

High

320443

AP3S2
AP-3 complex subunit sigma-2

2

1

High-throughput

0.628

High

320445

AT2B2
Plasma membrane calcium-transporting ATPase 2

2

3

High-throughput

0.628

High

320453

C3AR
C3a anaphylatoxin chemotactic receptor

2

5

High-throughput

0.628

High

320455

S4A8
Electroneutral sodium bicarbonate exchanger 1

2

2

High-throughput

0.628

High

320461

MFSD5
Molybdate-anion transporter

2

1

High-throughput

0.628

High

320466

TPRA1
Transmembrane protein adipocyte-associated 1

2

1

High-throughput

0.628

High

320473

AT11C
Phospholipid-transporting ATPase IG

2

2

High-throughput

0.628

High

320483

VPP1
V-type proton ATPase 116 kDa subunit a 1

2

3

High-throughput

0.628

High

320504

GHITM
Growth hormone-inducible transmembrane protein

2

1

High-throughput

0.628

High

320507

GPC5C
G-protein coupled receptor family C group 5 member C

2

1

High-throughput

0.628

High

127232

LEG8
Galectin-8

3

6

High-throughput

0.609

High

126033

AP3B1
AP-3 complex subunit beta-1

2

0

High-throughput

0.602

High

320419

PIGN
GPI ethanolamine phosphate transferase 1

2

0

High-throughput

0.602

High

320464

OSTA
Organic solute transporter subunit alpha

2

0

High-throughput

0.602

High

320508

SERC1
Serine incorporator 1

2

0

High-throughput

0.602

High

320491

S29A1
Equilibrative nucleoside transporter 1

2

0

High-throughput

0.576

High

320448

MFS10
Major facilitator superfamily domain-containing protein 10

2

2

High-throughput

0.574

High

320470

CISD2
CDGSH iron-sulfur domain-containing protein 2

2

1

High-throughput

0.574

High

320484

SARAF
Store-operated calcium entry-associated regulatory factor

2

2

High-throughput

0.574

High

320423

GPHRB
Golgi pH regulator B

2

2

High-throughput

0.549

High

186870

GPR37
Prosaposin receptor GPR37

1

1

High-throughput

0.541

High

320435

CCR2
C-C chemokine receptor type 2

1

4

High-throughput

0.541

High

165495

SCAM3
Secretory carrier-associated membrane protein 3

1

1

High-throughput

0.536

High

248461

O10H2
Olfactory receptor 10H2

1

1

High-throughput

0.536

High

320422

B3A2
Anion exchange protein 2

1

2

High-throughput

0.536

High

320424

ACHB
Acetylcholine receptor subunit beta

1

2

High-throughput

0.536

High

320440

CCR6
C-C chemokine receptor type 6

1

4

High-throughput

0.536

High

320444

AT2C1
Calcium-transporting ATPase type 2C member 1

1

2

High-throughput

0.536

High

320447

VPP3
V-type proton ATPase 116 kDa subunit a 3

1

3

High-throughput

0.536

High

320451

MSMO1
Methylsterol monooxygenase 1

1

2

High-throughput

0.536

High

320456

NKAI1
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

1

1

High-throughput

0.536

High

320458

TTMP
TPA-induced transmembrane protein

1

1

High-throughput

0.536

High

320471

M4A15
Membrane-spanning 4-domains subfamily A member 15

1

2

High-throughput

0.536

High

320474

SIDT2
SID1 transmembrane family member 2

1

1

High-throughput

0.536

High

320492

ZNT2
Proton-coupled zinc antiporter SLC30A2

1

5

High-throughput

0.536

High

320493

YIPF4
Protein YIPF4

1

2

High-throughput

0.536

High

320500

NMUR2
Neuromedin-U receptor 2

1

1

High-throughput

0.536

High

320503

TTYH1
Protein tweety homolog 1

1

1

High-throughput

0.536

High

320505

RXFP1
Relaxin receptor 1

1

2

High-throughput

0.536

High

320425

DRD2
D(2) dopamine receptor

1

0

High-throughput

0.518

High

184360

SURF4
Surfeit locus protein 4

1

0

High-throughput

0.513

High

320462

ATRAP
Type-1 angiotensin II receptor-associated protein

1

0

High-throughput

0.513

High

320463

PP4P1
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

1

0

High-throughput

0.513

High

320469

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.513

High

320476

TM87A
Transmembrane protein 87A

1

0

High-throughput

0.513

High

320477

CTL5
Choline transporter-like protein 5

1

0

High-throughput

0.513

High

320487

S41A3
Solute carrier family 41 member 3

1

0

High-throughput

0.513

High

320501

T126A
Transmembrane protein 126A

1

0

High-throughput

0.513

High

320516

AP3M1
AP-3 complex subunit mu-1

1

0

High-throughput

0.513

High

125113

LEG9
Galectin-9

1

6

High-throughput

0.489

High

225350

ERD23
ER lumen protein-retaining receptor 3

1

1

High-throughput

0.489

High

295900

SC5D
Lathosterol oxidase

1

2

High-throughput

0.489

High

320430

ERD21
ER lumen protein-retaining receptor 1

1

1

High-throughput

0.489

High

320468

VKORL
Vitamin K epoxide reductase complex subunit 1-like protein 1

1

1

High-throughput

0.489

High

320478

ZNT7
Zinc transporter 7

1

5

High-throughput

0.489

High

320486

ZDH12
Palmitoyltransferase ZDHHC12

1

3

High-throughput

0.489

High

320494

DERL1
Derlin-1

1

1

High-throughput

0.489

High

320509

DJC11
DnaJ homolog subfamily C member 11

1

1

High-throughput

0.489

High

320513

TMCO1
Calcium load-activated calcium channel

1

1

High-throughput

0.489

High

320517

ZDHC9
Palmitoyltransferase ZDHHC9

1

1

High-throughput

0.489

High

320432

5HT1E
5-hydroxytryptamine receptor 1E

1

1

High-throughput

0.445

High

320439

CXCR3
C-X-C chemokine receptor type 3

1

5

High-throughput

0.445

High

320441

CTR2
Cationic amino acid transporter 2

1

1

High-throughput

0.445

High

320454

S35G1
Solute carrier family 35 member G1

1

1

High-throughput

0.445

High

320482

LPAR1
Lysophosphatidic acid receptor 1

1

1

High-throughput

0.445

High

320420

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

320421

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.437

High

320426

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

320446

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.437

High

320514

S45A2
Membrane-associated transporter protein

1

1

High-throughput

0.437

High

320427

FAAA
Fumarylacetoacetase

1

0

High-throughput

0.426

High

320449

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

0

High-throughput

0.426

High

320502

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

0

High-throughput

0.426

High

94485

D6RGY6
Solute carrier family 45 member 2

1

1

High-throughput

0.407

High

320429

PTN1
Tyrosine-protein phosphatase non-receptor type 1

2

0

High-throughput

0.328

High

320472

ARL10
ADP-ribosylation factor-like protein 10

2

0

High-throughput

0.328

High

320510

TM242
Transmembrane protein 242

2

0

High-throughput

0.328

High

320519

ALG5
Dolichyl-phosphate beta-glucosyltransferase

2

0

High-throughput

0.328

High

184955

SPTC2
Serine palmitoyltransferase 2

1

0

High-throughput

0.279

Low

320450

DHC24
Delta(24)-sterol reductase

1

0

High-throughput

0.279

Low

320457

TM41B
Transmembrane protein 41B

1

0

High-throughput

0.279

Low

320460

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

0

High-throughput

0.279

Low

320465

GP180
Integral membrane protein GPR180

1

0

High-throughput

0.279

Low

320467

K2013
Uncharacterized protein KIAA2013

1

0

High-throughput

0.279

Low

320475

UBAC2
Ubiquitin-associated domain-containing protein 2

1

0

High-throughput

0.279

Low

320479

NPL4
Nuclear protein localization protein 4 homolog

1

0

High-throughput

0.279

Low

320480

THEM6
Protein THEM6

1

0

High-throughput

0.279

Low

320485

TV23C
Golgi apparatus membrane protein TVP23 homolog C

1

0

High-throughput

0.279

Low

320488

MBOA7
Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7

1

0

High-throughput

0.279

Low

320490

SGMR1
Sigma non-opioid intracellular receptor 1

1

0

High-throughput

0.279

Low

320496

PTSS2
Phosphatidylserine synthase 2

1

0

High-throughput

0.279

Low

320497

RIOK2
Serine/threonine-protein kinase RIO2

1

0

High-throughput

0.279

Low

320498

SFXN3
Sideroflexin-3

1

0

High-throughput

0.279

Low

320506

TPC
Mitochondrial thiamine pyrophosphate carrier

1

0

High-throughput

0.279

Low

320511

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.279

Low

320515

DOLK
Dolichol kinase

1

0

High-throughput

0.279

Low

320431

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

320433

EF1D
Elongation factor 1-delta

1

0

High-throughput

0.249

Low

320434

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

320437

GATA4
Transcription factor GATA-4

1

0

High-throughput

0.249

Low

230229

CREB3
Cyclic AMP-responsive element-binding protein 3

1

0

High-throughput

0.238

Low

320489

TTC1
Tetratricopeptide repeat protein 1

1

0

High-throughput

0.232

Low

320495

MTNA
Methylthioribose-1-phosphate isomerase

1

0

High-throughput

0.232

Low

320499

HDHD5
Haloacid dehalogenase-like hydrolase domain-containing 5

1

0

High-throughput

0.232

Low

320518

KAD6
Adenylate kinase isoenzyme 6

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025