Interactor 1: IL33 (O95760)
Interleukin-33 (IL-33) (Interleukin-1 family member 11) (IL-1F11) (Nuclear factor from high endothelial venules) (NF-HEV) [Cleaved into: Interleukin-33 (95-270); Interleukin-33 (99-270); Interleukin-33 (109-270)]
Gene: IL33

Interactor 2: CASP1 (P29466)
Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
Gene: CASP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.63 0.60 0.617

The method score is based on:

Property Details
Experiments 16286016, 19439663
Identification Methods enzymatic study, protease assay
Interaction Type direct interaction, protein cleavage

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005737 - cytoplasm
GO:0050729 - positive regulation of inflammatory response
GO:0051607 - defense response to virus
GO:0071260 - cellular response to mechanical stimulus
Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 270
Hs

1 404
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024