HitPredict

Interactor 1: AP2A1 (O95782)
AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit)
Gene: AP2A1

Interactor 2: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0019901 - protein kinase binding
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 977 Hs			1 509
+	Hs
		321450 AP2A1_HUMAN (1-977): 0: 904: 100.00		ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21
+	Hs
		69200 AP2A1_HUMAN (1-977): 0: 904: 100.00		A9UF07_HUMAN (49-502): 6.09e-165: 512: 42.21
+	Hs
		337419 AP2B1_HUMAN (34-972): 0: 676: 17.11		ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21
+	Hs
		69207 AP2B1_HUMAN (34-972): 0: 676: 17.11		A9UF07_HUMAN (49-502): 6.09e-165: 512: 42.21
+	Hs
		150158 AP3D1_HUMAN (11-746): 3.68e-150: 476: 20.55		LCK_HUMAN (1-509): 0: 661: 100.00