Protein: CLK3
Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3)

Gene: CLK3
Organism: Homo sapiens
Interactions: 216
UniProt ID: P49761

Gene Ontology (top 5):
GO:0001669 - acrosomal vesicle
GO:0003723 - RNA binding
GO:0004674 - protein serine/threonine kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity
GO:0004713 - protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

889537

CLK2
Dual specificity protein kinase CLK2

8

17

High-throughput

0.975

High

889774

SNIP1
Smad nuclear-interacting protein 1

6

2

High-throughput

0.944

High

889708

SRPK2
SRSF protein kinase 2

5

18

High-throughput

0.939

High

889727

TRA2A
Transformer-2 protein homolog alpha

5

20

High-throughput

0.932

High

889706

TRA2B
Transformer-2 protein homolog beta

5

20

High-throughput

0.931

High

889799

SRSF8
Serine/arginine-rich splicing factor 8

5

14

High-throughput

0.927

High

889725

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

4

13

High-throughput

0.909

High

889730

SCRIB
Protein scribble homolog

4

3

High-throughput

0.909

High

889802

LRRC1
Leucine-rich repeat-containing protein 1

4

4

High-throughput

0.909

High

461274

HS90A
Heat shock protein HSP 90-alpha

4

20

High-throughput

0.903

High

284096

SRS10
Serine/arginine-rich splicing factor 10

4

20

High-throughput

0.902

High

889738

RNPS1
RNA-binding protein with serine-rich domain 1

4

15

High-throughput

0.902

High

889690

CLK3
Dual specificity protein kinase CLK3

4

16

High-throughput

0.896

High

889716

SRSF1
Serine/arginine-rich splicing factor 1

3

20

High-throughput

0.863

High

468183

HS90B
Heat shock protein HSP 90-beta

3

20

High-throughput

0.861

High

472533

RU17
U1 small nuclear ribonucleoprotein 70 kDa

3

15

High-throughput

0.861

High

889711

SRSF3
Serine/arginine-rich splicing factor 3

3

20

High-throughput

0.858

High

889741

CDC37
Hsp90 co-chaperone Cdc37

5

5

High-throughput

0.837

High

462300

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

2

20

High-throughput

0.811

High

685452

U2AF2
Splicing factor U2AF 65 kDa subunit

2

20

High-throughput

0.811

High

889720

ELAV2
ELAV-like protein 2

2

15

High-throughput

0.811

High

889735

ZN638
Zinc finger protein 638

2

11

High-throughput

0.811

High

889743

SRSF7
Serine/arginine-rich splicing factor 7

2

20

High-throughput

0.811

High

889777

SRS12
Serine/arginine-rich splicing factor 12

2

20

High-throughput

0.811

High

302432

RNF8
E3 ubiquitin-protein ligase RNF8

2

8

High-throughput

0.783

High

889742

U1SBP
U11/U12 small nuclear ribonucleoprotein 35 kDa protein

2

14

High-throughput

0.783

High

889776

ZN473
Zinc finger protein 473

2

2

High-throughput

0.783

High

889835

ZN777
Zinc finger protein 777

2

3

High-throughput

0.783

High

889839

ZN835
Zinc finger protein 835

2

1

High-throughput

0.783

High

889781

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

6

Small-scale

0.747

High

171849

ZN263
Zinc finger protein 263

1

3

High-throughput

0.740

High

515832

RBY1A
RNA-binding motif protein, Y chromosome, family 1 member A1

1

20

High-throughput

0.740

High

794410

RBMX
RNA-binding motif protein, X chromosome

1

20

High-throughput

0.740

High

889739

RBY1F
RNA-binding motif protein, Y chromosome, family 1 member F/J

1

20

High-throughput

0.740

High

889701

PSME3
Proteasome activator complex subunit 3

6

2

High-throughput

0.738

High

889846

TNPO3
Transportin-3

5

11

High-throughput

0.725

High

889803

RSRP1
Arginine/serine-rich protein 1

5

1

High-throughput

0.722

High

889703

1433G
14-3-3 protein gamma

5

20

High-throughput

0.714

High

889832

GPTC8
G patch domain-containing protein 8

4

10

High-throughput

0.704

High

889838

SRRM2
Serine/arginine repetitive matrix protein 2

4

20

High-throughput

0.704

High

154424

SH2B2
SH2B adapter protein 2

2

14

High-throughput

0.700

High

889762

RBBP6
E3 ubiquitin-protein ligase RBBP6

4

11

High-throughput

0.699

High

74452

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

20

High-throughput

0.691

High

251543

CCNT1
Cyclin-T1

1

20

High-throughput

0.691

High

256596

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

20

High-throughput

0.691

High

550182

PABP1
Polyadenylate-binding protein 1

1

10

High-throughput

0.691

High

889691

CDK9
Cyclin-dependent kinase 9

1

17

High-throughput

0.691

High

889705

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

3

High-throughput

0.691

High

889715

SRS11
Serine/arginine-rich splicing factor 11

1

9

High-throughput

0.691

High

889717

SRSF4
Serine/arginine-rich splicing factor 4

1

20

High-throughput

0.691

High

889721

SRSF5
Serine/arginine-rich splicing factor 5

1

20

High-throughput

0.691

High

889722

SRSF6
Serine/arginine-rich splicing factor 6

1

20

High-throughput

0.691

High

889723

PABP4
Polyadenylate-binding protein 4

1

10

High-throughput

0.691

High

889726

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

18

High-throughput

0.691

High

889729

SAFB2
Scaffold attachment factor B2

1

20

High-throughput

0.691

High

889733

RRP5
Protein RRP5 homolog

1

8

High-throughput

0.691

High

889746

LARP7
La-related protein 7

1

20

High-throughput

0.691

High

889786

PABP5
Polyadenylate-binding protein 5

1

12

High-throughput

0.691

High

889787

RMXL1
RNA binding motif protein, X-linked-like-1

1

20

High-throughput

0.691

High

889795

SRPK1
SRSF protein kinase 1

1

18

High-throughput

0.691

High

889796

RBM15
RNA-binding protein 15

1

19

High-throughput

0.691

High

889806

PDIP3
Polymerase delta-interacting protein 3

1

3

High-throughput

0.691

High

889824

SLTM
SAFB-like transcription modulator

1

20

High-throughput

0.691

High

889830

PUF60
Poly(U)-binding-splicing factor PUF60

1

20

High-throughput

0.691

High

889842

LC7L2
Putative RNA-binding protein Luc7-like 2

4

7

High-throughput

0.691

High

140183

SDCB1
Syntenin-1

3

9

High-throughput

0.675

High

484821

HXB7
Homeobox protein Hox-B7

3

7

High-throughput

0.675

High

604997

HXB6
Homeobox protein Hox-B6

3

5

High-throughput

0.675

High

889756

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

3

5

High-throughput

0.675

High

889760

MEPCE
7SK snRNA methylphosphate capping enzyme

3

3

High-throughput

0.675

High

889807

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

3

5

High-throughput

0.675

High

889808

PIP30
PSME3-interacting protein

4

0

High-throughput

0.670

High

715057

OAS2
2'-5'-oligoadenylate synthase 2

4

0

High-throughput

0.668

High

889763

ZCH18
Zinc finger CCCH domain-containing protein 18

3

18

High-throughput

0.667

High

889811

PININ
Pinin

3

3

High-throughput

0.667

High

889771

CLASR
CLK4-associating serine/arginine rich protein

3

9

High-throughput

0.665

High

889707

1433Z
14-3-3 protein zeta/delta

3

20

High-throughput

0.662

High

889714

1433F
14-3-3 protein eta

4

20

High-throughput

0.636

High

138917

USP9Y
Ubiquitin carboxyl-terminal hydrolase 9Y

2

12

High-throughput

0.628

High

229985

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

2

7

High-throughput

0.628

High

889724

PPIG
Peptidyl-prolyl cis-trans isomerase G

2

6

High-throughput

0.628

High

889751

ZC3HD
Zinc finger CCCH domain-containing protein 13

2

20

High-throughput

0.628

High

889752

PR38B
Pre-mRNA-splicing factor 38B

2

9

High-throughput

0.628

High

889758

LARP1
La-related protein 1

2

16

High-throughput

0.628

High

889770

ERF3B
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

2

4

High-throughput

0.628

High

889773

PPHLN
Periphilin-1

2

2

High-throughput

0.628

High

889782

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

2

12

High-throughput

0.628

High

889788

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

11

High-throughput

0.628

High

889794

YTDC1
YTH domain-containing protein 1

2

6

High-throughput

0.628

High

889798

ANM1
Protein arginine N-methyltransferase 1

2

6

High-throughput

0.628

High

889820

TOPRS
E3 ubiquitin-protein ligase Topors

2

5

High-throughput

0.628

High

889826

BCLF1
Bcl-2-associated transcription factor 1

2

15

High-throughput

0.628

High

889833

ACINU
Apoptotic chromatin condensation inducer in the nucleus

2

18

High-throughput

0.628

High

889841

TR150
Thyroid hormone receptor-associated protein 3

2

20

High-throughput

0.628

High

889816

SLAF7
SLAM family member 7

1

6

High-throughput

0.625

High

214745

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

10

High-throughput

0.621

High

889700

CDC42
Cell division control protein 42 homolog

1

4

High-throughput

0.618

High

889702

RHOA
Transforming protein RhoA

1

4

High-throughput

0.618

High

889731

RBM39
RNA-binding protein 39

1

20

High-throughput

0.618

High

889818

ANLN
Anillin

1

2

High-throughput

0.618

High

889817

LUC7L
Putative RNA-binding protein Luc7-like 1

3

6

High-throughput

0.609

High

478317

HXC4
Homeobox protein Hox-C4

2

4

High-throughput

0.606

High

522538

ARRS
S-arrestin

2

1

High-throughput

0.606

High

889719

INCA1
Protein INCA1

2

1

High-throughput

0.606

High

889750

NKAPL
NKAP-like protein

2

2

High-throughput

0.606

High

889768

CHERP
Calcium homeostasis endoplasmic reticulum protein

2

3

High-throughput

0.606

High

889827

NXF1
Nuclear RNA export factor 1

2

2

High-throughput

0.606

High

889734

LBR
Delta(14)-sterol reductase LBR

2

0

High-throughput

0.602

High

889754

VIR
Protein virilizer homolog

2

0

High-throughput

0.602

High

690832

1433T
14-3-3 protein theta

2

20

High-throughput

0.601

High

729683

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.601

High

889693

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

2

10

High-throughput

0.584

High

889747

H90B4
Putative heat shock protein HSP 90-beta 4

1

20

High-throughput

0.575

High

889748

H90B3
Putative heat shock protein HSP 90-beta-3

1

20

High-throughput

0.575

High

889759

NKAP1
Uncharacterized protein NKAPD1

2

1

High-throughput

0.574

High

889792

SAHH3
Adenosylhomocysteinase 3

2

7

High-throughput

0.574

High

216394

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

2

High-throughput

0.573

High

395701

ESR1
Estrogen receptor

2

11

High-throughput

0.571

High

889775

LNX1
E3 ubiquitin-protein ligase LNX

2

10

High-throughput

0.553

High

889785

DDT4L
DNA damage-inducible transcript 4-like protein

2

1

High-throughput

0.553

High

889813

PKHA4
Pleckstrin homology domain-containing family A member 4

1

11

High-throughput

0.553

High

889801

TINF2
TERF1-interacting nuclear factor 2

1

0

High-throughput

0.549

High

124750

AIP
AH receptor-interacting protein

1

10

High-throughput

0.536

High

134610

SAP18
Histone deacetylase complex subunit SAP18

1

3

High-throughput

0.536

High

183438

CASC3
Protein CASC3

1

6

High-throughput

0.536

High

192563

NUP42
Nucleoporin NUP42

1

1

High-throughput

0.536

High

253600

IMA7
Importin subunit alpha-7

1

9

High-throughput

0.536

High

272903

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

1

High-throughput

0.536

High

324647

HEXI1
Protein HEXIM1

1

4

High-throughput

0.536

High

325732

UBR5
E3 ubiquitin-protein ligase UBR5

1

14

High-throughput

0.536

High

344134

PTBP3
Polypyrimidine tract-binding protein 3

1

14

High-throughput

0.536

High

413413

P53
Cellular tumor antigen p53

1

6

High-throughput

0.536

High

669846

MCM3
DNA replication licensing factor MCM3

1

8

High-throughput

0.536

High

889695

IMA5
Importin subunit alpha-5

1

9

High-throughput

0.536

High

889698

RRP1
Ribosomal RNA processing protein 1 homolog A

1

2

High-throughput

0.536

High

889718

NCBP1
Nuclear cap-binding protein subunit 1

1

2

High-throughput

0.536

High

889732

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

6

High-throughput

0.536

High

889736

IMB1
Importin subunit beta-1

1

5

High-throughput

0.536

High

889744

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

15

High-throughput

0.536

High

889745

RN151
RING finger protein 151

1

17

High-throughput

0.536

High

889753

LAR1B
La-related protein 1B

1

14

High-throughput

0.536

High

889757

ZC3HE
Zinc finger CCCH domain-containing protein 14

1

1

High-throughput

0.536

High

889764

CARM1
Histone-arginine methyltransferase CARM1

1

6

High-throughput

0.536

High

889765

SPAS2
Spermatogenesis-associated serine-rich protein 2

1

2

High-throughput

0.536

High

889766

ABC3F
DNA dC->dU-editing enzyme APOBEC-3F

1

4

High-throughput

0.536

High

889769

SRRM1
Serine/arginine repetitive matrix protein 1

1

16

High-throughput

0.536

High

889778

LAR4B
La-related protein 4B

1

14

High-throughput

0.536

High

889783

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

12

High-throughput

0.536

High

889791

CHMP6
Charged multivesicular body protein 6

1

5

High-throughput

0.536

High

889793

ZFR
Zinc finger RNA-binding protein

1

9

High-throughput

0.536

High

889805

SRRT
Serrate RNA effector molecule homolog

1

2

High-throughput

0.536

High

889809

PAIP1
Polyadenylate-binding protein-interacting protein 1

1

5

High-throughput

0.536

High

889814

LN28A
Protein lin-28 homolog A

1

8

High-throughput

0.536

High

889822

SPS2L
SPATS2-like protein

1

2

High-throughput

0.536

High

889823

ARGL1
Arginine and glutamate-rich protein 1

1

2

High-throughput

0.536

High

889825

LYAR
Cell growth-regulating nucleolar protein

1

1

High-throughput

0.536

High

889828

DAXX
Death domain-associated protein 6

1

1

High-throughput

0.536

High

889831

PURG
Purine-rich element-binding protein gamma

1

3

High-throughput

0.536

High

889834

ZN346
Zinc finger protein 346

1

1

High-throughput

0.536

High

889837

CHIP
E3 ubiquitin-protein ligase CHIP

1

4

High-throughput

0.536

High

889840

YBOX2
Y-box-binding protein 2

1

4

High-throughput

0.536

High

889845

CHTOP
Chromatin target of PRMT1 protein

1

2

High-throughput

0.536

High

889847

RT18B
Small ribosomal subunit protein mS40

1

1

High-throughput

0.536

High

889848

CFA20
Cilia- and flagella-associated protein 20

1

1

High-throughput

0.536

High

167068

GEMI2
Gem-associated protein 2

1

0

High-throughput

0.513

High

480057

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

889709

RT35
Small ribosomal subunit protein mS35

1

0

High-throughput

0.513

High

889779

RT31
Small ribosomal subunit protein mS31

1

0

High-throughput

0.513

High

889789

PTCD3
Small ribosomal subunit protein mS39

1

0

High-throughput

0.513

High

889790

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.513

High

889843

RT23
Small ribosomal subunit protein mS23

1

0

High-throughput

0.513

High

889844

CCDC9
Coiled-coil domain-containing protein 9

1

0

High-throughput

0.513

High

889849

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.513

High

162505

ANM5
Protein arginine N-methyltransferase 5

1

8

High-throughput

0.508

High

421725

A4
Amyloid-beta precursor protein

1

7

High-throughput

0.501

High

861520

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

10

High-throughput

0.501

High

889810

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

0

High-throughput

0.493

High

889767

PLD3
5'-3' exonuclease PLD3

1

2

High-throughput

0.489

High

889772

ARFG2
ADP-ribosylation factor GTPase-activating protein 2

1

2

High-throughput

0.489

High

889784

SH3K1
SH3 domain-containing kinase-binding protein 1

1

1

High-throughput

0.489

High

889812

E41L1
Band 4.1-like protein 1

1

7

High-throughput

0.489

High

889836

PAI2B
Polyadenylate-binding protein-interacting protein 2B

1

1

High-throughput

0.489

High

285144

EED
Polycomb protein EED

1

16

High-throughput

0.479

High

371476

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.479

High

694926

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

704727

ERCC5
DNA excision repair protein ERCC-5

1

11

High-throughput

0.479

High

730454

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

744641

TF2H1
General transcription factor IIH subunit 1

1

3

High-throughput

0.479

High

785014

RL4
Large ribosomal subunit protein uL4

1

2

High-throughput

0.479

High

889692

MECP2
Methyl-CpG-binding protein 2

1

5

High-throughput

0.479

High

889694

IMA1
Importin subunit alpha-1

1

9

High-throughput

0.479

High

889696

TERF1
Telomeric repeat-binding factor 1

1

8

High-throughput

0.479

High

889704

1433E
14-3-3 protein epsilon

1

8

High-throughput

0.479

High

889712

ENL
Protein ENL

1

14

High-throughput

0.479

High

889713

TF65
Transcription factor p65

1

7

High-throughput

0.479

High

889728

TF2H3
General transcription factor IIH subunit 3

1

2

High-throughput

0.479

High

889737

TNIP1
TNFAIP3-interacting protein 1

1

19

High-throughput

0.479

High

889740

TERF2
Telomeric repeat-binding factor 2

1

9

High-throughput

0.479

High

889749

Q59FZ7
DNA excision repair protein ERCC-5

1

11

High-throughput

0.479

High

889761

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.479

High

889780

ESR2
Estrogen receptor beta

1

11

High-throughput

0.479

High

889804

HIRP3
HIRA-interacting protein 3

1

4

High-throughput

0.479

High

889815

RC3H2
Roquin-2

1

12

High-throughput

0.479

High

889821

RAD18
E3 ubiquitin-protein ligase RAD18

1

2

High-throughput

0.479

High

889829

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

889819

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.460

High

889797

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.458

High

889697

SUMO3
Small ubiquitin-related modifier 3

1

3

Small-scale

0.445

High

889699

KR103
Keratin-associated protein 10-3

1

8

High-throughput

0.439

High

105574

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

889755

Q6ICH2
single-stranded DNA cytosine deaminase

1

4

High-throughput

0.437

High

889800

ATGA1
Autophagy-related protein 101

1

2

High-throughput

0.437

High

73379

B2CML4
single-stranded DNA cytosine deaminase

1

4

High-throughput

0.407

High

229518

NRDC
Nardilysin

1

0

High-throughput

0.279

Low

889710

RT34
Small ribosomal subunit protein mS34

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025