HitPredict

Interactor 1: BAG3 (O95817)
BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1)
Gene: BAG3

Interactor 2: HSPB2 (Q16082)
Heat shock protein beta-2 (HspB2) (DMPK-binding protein) (MKBP) (Heat shock protein family B member 2)
Gene: HSPB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.665

Property	Details
Experiments	32296183, 33961781, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, validated two hybrid, two hybrid prey pooling approach, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043066 - negative regulation of apoptotic process
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 575 Hs			1 182
+	Hs
		324154 BAG3_HUMAN (1-575): 0: 809: 100.00		CRYAA_HUMAN (5-174): 1.85e-56: 177: 34.30
+	Hs
		324155 BAG3_HUMAN (1-575): 0: 809: 100.00		CRYAB_HUMAN (6-174): 2.32e-55: 174: 35.67
+	Hs
		324160 BAG3_HUMAN (1-575): 0: 809: 100.00		HSPB1_HUMAN (1-179): 7.82e-55: 174: 32.85
+	Hs
		147842 BAG3_HUMAN (1-575): 0: 809: 100.00		HSPB6_HUMAN (6-144): 5.8e-42: 139: 40.28
+	Hs
		324673 BAG3_HUMAN (1-575): 0: 809: 100.00		HSPB8_HUMAN (1-170): 1.27e-38: 132: 25.00
+	Mm
		1337503 BAG3_MOUSE (1-575): 0: 762: 83.31		HSPB8_MOUSE (1-170): 4.24e-39: 133: 26.04
+	Dm
		65603 A8JNS4_DROME (398-498): 1.33e-26: 116: 32.11		HSP6C_DROME (69-182): 3.56e-34: 121: 32.52
+	Dm
		1374285 Q9VU81_DROME (398-498): 1.2e-26: 116: 32.11		Q9VWG1_DROME (34-166): 1.9e-30: 111: 26.28
+	Dm
		65596 A8JNS4_DROME (398-498): 1.33e-26: 116: 32.11		M9NHC5_DROME (51-149): 6.96e-31: 111: 32.04