HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: RAP2A (P10114)
Ras-related protein Rap-2a (EC 3.6.5.2) (RbBP-30)
Gene: RAP2A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	32640226, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0046328 - regulation of JNK cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1239 Hs			1 183
+	Hs
		324909 M4K4_HUMAN (1-1239): 0: 1227: 100.00		RAP2C_HUMAN (1-183): 2.97e-81: 240: 91.26
+	Hs
		324774 M4K4_HUMAN (1-1239): 0: 1227: 100.00		RB11A_HUMAN (4-179): 1.08e-73: 222: 30.51
+	Hs
		324710 M4K4_HUMAN (1-1239): 0: 1227: 100.00		RASH_HUMAN (1-180): 3.16e-48: 156: 46.49
+	Hs
		486037 MINK1_HUMAN (1-1239): 0: 1120: 59.29		RAP2A_HUMAN (1-183): 7.32e-82: 241: 100.00
+	Hs
		486057 TNIK_HUMAN (1-1239): 0: 1101: 60.56		RAP2A_HUMAN (1-183): 7.32e-82: 241: 100.00
+	Xl
		1150218 Q6DDZ8_XENLA (1-1239): 0: 1097: 59.58		Q7ZX67_XENLA (16-183): 1.44e-78: 233: 98.81
+	Hs
		349478 MINK1_HUMAN (1-1239): 0: 1120: 59.29		RASH_HUMAN (1-180): 3.16e-48: 156: 46.49
+	Hs
		349719 TNIK_HUMAN (1-1239): 0: 1101: 60.56		RASH_HUMAN (1-180): 3.16e-48: 156: 46.49
+	Hs
		148636 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		RAB1A_HUMAN (4-183): 5.73e-80: 238: 34.25
+	Hs
		647857 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		RAB2A_HUMAN (4-183): 2.04e-74: 224: 35.36
+	Hs
		149274 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		RAB1B_HUMAN (4-178): 1.24e-76: 229: 34.09
+	Hs
		647864 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		RB11A_HUMAN (4-179): 1.08e-73: 222: 30.51
+	Hs
		895142 MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10		RAB2A_HUMAN (4-183): 2.04e-74: 224: 35.36
+	Hs
		914159 MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10		RB11A_HUMAN (4-179): 1.08e-73: 222: 30.51
+	Hs
		682159 AKT2_HUMAN (2-354): 7.38e-124: 393: 21.98		RAB2A_HUMAN (4-183): 2.04e-74: 224: 35.36
+	Hs
		254463 ROCK2_HUMAN (15-536): 8.84e-107: 369: 22.02		RAB2A_HUMAN (4-183): 2.04e-74: 224: 35.36
+	Hs
		254466 ROCK2_HUMAN (15-536): 8.84e-107: 369: 22.02		RB11A_HUMAN (4-179): 1.08e-73: 222: 30.51
+	Hs
		349139 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		RASH_HUMAN (1-180): 3.16e-48: 156: 46.49
+	Hs
		349425 MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10		RASH_HUMAN (1-180): 3.16e-48: 156: 46.49
+	Hs
		254429 ROCK2_HUMAN (15-536): 8.84e-107: 369: 22.02		RASH_HUMAN (1-180): 3.16e-48: 156: 46.49