HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35063084
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0008017 - microtubule binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1239 Hs			1 758
+	Hs
		497766 TNIK_HUMAN (1-1239): 0: 1101: 60.56		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		1356429 TNIK_HUMAN (1-1239): 0: 1101: 60.56		PCLO_HUMAN (46-758): 3.43e-16: 85.9: 9.19
+	Hs
		497840 SIK3_HUMAN (7-915): 2.5e-127: 426: 15.13		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496358 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		497452 MARK4_HUMAN (16-693): 2.51e-123: 400: 18.06		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		497224 MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496408 AKT2_HUMAN (2-354): 7.38e-124: 393: 21.98		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		497338 BRSK1_HUMAN (22-753): 9.31e-120: 391: 17.08		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496407 AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		254438 ROCK2_HUMAN (15-536): 8.84e-107: 369: 22.02		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		497903 STK24_HUMAN (20-398): 2.05e-110: 355: 36.65		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		503266 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55
+	Hs
		654032 MARK4_HUMAN (16-693): 2.51e-123: 400: 18.06		MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56
+	Hs
		503298 MARK4_HUMAN (16-693): 2.51e-123: 400: 18.06		MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55
+	Hs
		148818 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57
+	Hs
		152597 AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82		KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55
+	Hs
		149481 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		PCLO_HUMAN (46-758): 3.43e-16: 85.9: 9.19