HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: NUMA1 (Q14980)
Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen)
Gene: NUMA1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0008017 - microtubule binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1239 Hs			1 2115
+	Hs
		324836 M4K4_HUMAN (1-1239): 0: 1227: 100.00		CNTRL_HUMAN (3-811): 1.27e-16: 89.3: 11.29
+	Mm
		93424 TNIK_MOUSE (1-1239): 0: 1120: 62.43		E9Q3P4_MOUSE (562-1890): 5.59e-30: 133: 11.42
+	Mm
		949273 TNIK_MOUSE (1-1239): 0: 1120: 62.43		Q155P7_MOUSE (562-1890): 5.59e-30: 133: 11.42
+	Hs
		1034641 TNIK_HUMAN (1-1239): 0: 1101: 60.56		GOGA4_HUMAN (5-528): 2.18e-12: 75: 11.24
+	Hs
		148830 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00
+	Hs
		148460 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		MYH9_HUMAN (1033-1891): 1.22e-33: 145: 10.62
+	Hs
		148461 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		MYH10_HUMAN (1281-2075): 5.26e-33: 142: 12.34
+	Hs
		148841 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		PLEC_HUMAN (45-1230): 3.46e-32: 140: 13.37
+	Hs
		724967 MARK4_HUMAN (16-693): 2.51e-123: 400: 18.06		MYH9_HUMAN (1033-1891): 1.22e-33: 145: 10.62
+	Hs
		725223 MARK4_HUMAN (16-693): 2.51e-123: 400: 18.06		MYH10_HUMAN (1281-2075): 5.26e-33: 142: 12.34
+	Hs
		522610 STK3_HUMAN (4-499): 3.17e-119: 381: 30.60		MYH7_HUMAN (947-2023): 1.11e-36: 155: 11.21
+	Hs
		681696 AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82		MYH9_HUMAN (1033-1891): 1.22e-33: 145: 10.62
+	Hs
		522546 STK3_HUMAN (4-499): 3.17e-119: 381: 30.60		MYH1_HUMAN (1-831): 3.6e-35: 150: 12.27
+	Hs
		528409 STK3_HUMAN (4-499): 3.17e-119: 381: 30.60		MYH8_HUMAN (1122-2115): 6.23e-35: 149: 10.31
+	Hs
		528371 STK3_HUMAN (4-499): 3.17e-119: 381: 30.60		MYH6_HUMAN (1-883): 5.66e-32: 139: 13.37
+	Hs
		148466 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		MYH11_HUMAN (1430-2076): 4.75e-22: 107: 8.41
+	Hs
		148338 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		TPR_HUMAN (2-620): 2.42e-18: 94.7: 12.04
+	Hs
		502912 STK3_HUMAN (4-499): 3.17e-119: 381: 30.60		MYH3_HUMAN (930-1731): 1.32e-24: 115: 12.39
+	Hs
		148769 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		GOGA4_HUMAN (5-528): 2.18e-12: 75: 11.24
+	Hs
		148534 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		CENPF_HUMAN (1458-2037): 1.6e-10: 69.3: 9.97