Protein: HTSF1
17S U2 SnRNP complex component HTATSF1 (HIV Tat-specific factor 1) (Tat-SF1)

Gene: HTSF1, HTATSF1
Organism: Homo sapiens
Interactions: 125
UniProt ID: O43719

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0000724 - double-strand break repair via homologous recombination
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

225245

RU2A
U2 small nuclear ribonucleoprotein A'

4

5

High-throughput

0.892

High

225232

SF3B1
Splicing factor 3B subunit 1

3

5

Small-scale

0.880

High

225348

RBM7
RNA-binding protein 7

3

16

High-throughput

0.861

High

225293

SF3A2
Splicing factor 3A subunit 2

3

10

Small-scale

0.847

High

225243

RU2B
U2 small nuclear ribonucleoprotein B''

2

19

High-throughput

0.811

High

225300

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

6

High-throughput

0.737

High

225276

CSK21
Casein kinase II subunit alpha

1

15

High-throughput

0.710

High

225262

KC1A
Casein kinase I isoform alpha

1

3

High-throughput

0.691

High

225278

KC1G2
Casein kinase I isoform gamma-2

1

17

High-throughput

0.691

High

225287

SF3B2
Splicing factor 3B subunit 2

1

4

High-throughput

0.691

High

225295

STK11
Serine/threonine-protein kinase STK11

1

4

High-throughput

0.691

High

225318

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

20

High-throughput

0.691

High

225346

SF3B6
Splicing factor 3B subunit 6

1

18

High-throughput

0.691

High

225270

RUXF
Small nuclear ribonucleoprotein F

3

10

High-throughput

0.675

High

225250

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

3

8

High-throughput

0.671

High

225274

RSMN
Small nuclear ribonucleoprotein-associated protein N

3

10

High-throughput

0.667

High

225282

SRSF4
Serine/arginine-rich splicing factor 4

1

18

High-throughput

0.656

High

225264

CLK1
Dual specificity protein kinase CLK1

1

20

High-throughput

0.647

High

225277

SRPK2
SRSF protein kinase 2

1

20

High-throughput

0.647

High

225269

RUXE
Small nuclear ribonucleoprotein E

2

2

High-throughput

0.628

High

225244

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

16

High-throughput

0.618

High

225279

EWS
RNA-binding protein EWS

1

20

High-throughput

0.618

High

225283

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

19

High-throughput

0.618

High

225286

TIF1B
Transcription intermediary factor 1-beta

1

17

High-throughput

0.618

High

225290

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

19

High-throughput

0.618

High

225298

LARP7
La-related protein 7

1

18

High-throughput

0.618

High

225320

RBP56
TATA-binding protein-associated factor 2N

1

18

High-throughput

0.618

High

225335

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

6

High-throughput

0.618

High

225339

DJC17
DnaJ homolog subfamily C member 17

1

3

High-throughput

0.618

High

225342

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.618

High

225271

RUXG
Small nuclear ribonucleoprotein G

2

16

High-throughput

0.611

High

225302

IFIX
Pyrin and HIN domain-containing protein 1

2

4

High-throughput

0.611

High

225329

TEAN2
Transcription elongation factor A N-terminal and central domain-containing protein 2

2

0

High-throughput

0.602

High

225231

BRD4
Bromodomain-containing protein 4

2

11

High-throughput

0.584

High

225265

NCBP2
Nuclear cap-binding protein subunit 2

1

18

High-throughput

0.575

High

225341

HDAC6
Protein deacetylase HDAC6

1

17

Small-scale

0.573

High

225319

ESR2
Estrogen receptor beta

2

20

High-throughput

0.571

High

225247

TAU
Microtubule-associated protein tau

1

20

High-throughput

0.536

High

225257

ARRB2
Beta-arrestin-2

1

3

High-throughput

0.536

High

225261

NOTC1
Neurogenic locus notch homolog protein 1

1

2

High-throughput

0.536

High

225263

SRP09
Signal recognition particle 9 kDa protein

1

1

High-throughput

0.536

High

225272

SMD2
Small nuclear ribonucleoprotein Sm D2

1

3

High-throughput

0.536

High

225289

CUL3
Cullin-3

1

20

High-throughput

0.536

High

225294

SF3A1
Splicing factor 3A subunit 1

1

8

High-throughput

0.536

High

225308

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

4

High-throughput

0.536

High

225322

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

1

High-throughput

0.536

High

225323

RNF25
E3 ubiquitin-protein ligase RNF25

1

1

High-throughput

0.536

High

225337

AGO4
Protein argonaute-4

1

13

High-throughput

0.536

High

225238

PAK4
Serine/threonine-protein kinase PAK 4

1

4

High-throughput

0.514

High

225236

SLU7
Pre-mRNA-splicing factor SLU7

1

0

High-throughput

0.513

High

225266

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.513

High

225306

PHF5A
PHD finger-like domain-containing protein 5A

1

0

High-throughput

0.513

High

225338

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.513

High

225327

Z512B
Zinc finger protein 512B

1

8

High-throughput

0.508

High

126919

APBB1
Amyloid beta precursor protein binding family B member 1

1

1

High-throughput

0.501

High

225230

CCNT1
Cyclin-T1

1

4

Small-scale

0.501

High

225233

WBP4
WW domain-binding protein 4

1

12

High-throughput

0.501

High

225280

ERCC6
DNA excision repair protein ERCC-6

1

20

High-throughput

0.501

High

225299

FWCH1
FLYWCH-type zinc finger-containing protein 1

1

0

High-throughput

0.493

High

225313

NGEF
Ephexin-1

1

7

High-throughput

0.489

High

225315

RIN3
Ras and Rab interactor 3

1

7

High-throughput

0.489

High

130313

SPT5H
Transcription elongation factor SPT5

1

9

Small-scale

0.479

High

225229

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.479

High

225235

HEXI1
Protein HEXIM1

1

6

High-throughput

0.479

High

225237

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

2

High-throughput

0.479

High

225239

EGFR
Epidermal growth factor receptor

1

7

High-throughput

0.479

High

225241

P53
Cellular tumor antigen p53

1

8

High-throughput

0.479

High

225242

NPM
Nucleophosmin

1

4

High-throughput

0.479

High

225248

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.479

High

225249

T2FB
General transcription factor IIF subunit 2

1

1

Small-scale

0.479

High

225251

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

225252

H2AX
Histone H2AX

1

8

High-throughput

0.479

High

225253

CEBPB
CCAAT/enhancer-binding protein beta

1

13

High-throughput

0.479

High

225254

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

8

Small-scale

0.479

High

225255

EF1D
Elongation factor 1-delta

1

2

High-throughput

0.479

High

225258

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

225259

COIL
Coilin

1

1

High-throughput

0.479

High

225260

CCNF
Cyclin-F

1

6

High-throughput

0.479

High

225267

UBC12
NEDD8-conjugating enzyme Ubc12

1

2

High-throughput

0.479

High

225268

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

225273

H4
Histone H4

1

6

High-throughput

0.479

High

225281

TF65
Transcription factor p65

1

5

High-throughput

0.479

High

225284

REST
RE1-silencing transcription factor

1

6

High-throughput

0.479

High

225285

CBX3
Chromobox protein homolog 3

1

5

High-throughput

0.479

High

225291

SUZ12
Polycomb protein SUZ12

1

4

High-throughput

0.479

High

225292

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

High-throughput

0.479

High

225297

EZH2
Histone-lysine N-methyltransferase EZH2

1

12

High-throughput

0.479

High

225301

VIR
Protein virilizer homolog

1

3

High-throughput

0.479

High

225305

H32
Histone H3.2

1

3

Small-scale

0.479

High

225307

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

7

High-throughput

0.479

High

225309

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

225311

SMC5
Structural maintenance of chromosomes protein 5

1

7

High-throughput

0.479

High

225314

SERB1
SERPINE1 mRNA-binding protein 1

1

6

High-throughput

0.479

High

225317

TOPB1
DNA topoisomerase 2-binding protein 1

1

11

High-throughput

0.479

High

225321

CSN5
COP9 signalosome complex subunit 5

1

9

High-throughput

0.479

High

225324

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

17

High-throughput

0.479

High

225330

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

4

High-throughput

0.479

High

225332

DNJC2
DnaJ homolog subfamily C member 2

1

3

High-throughput

0.479

High

225334

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

1

2

High-throughput

0.479

High

225344

NUP50
Nuclear pore complex protein Nup50

1

3

High-throughput

0.479

High

225347

TRRAP
Transformation/transcription domain-associated protein

1

5

High-throughput

0.479

High

225331

UIF
UAP56-interacting factor

1

0

Small-scale

0.458

High

225340

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

225336

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

20

High-throughput

0.457

High

71543

RUXGL
Putative small nuclear ribonucleoprotein G-like protein 15

1

16

High-throughput

0.445

High

225288

SNW1
SNW domain-containing protein 1

1

5

High-throughput

0.445

High

225310

S2611
Sodium-independent sulfate anion transporter

1

1

High-throughput

0.445

High

225343

DDX41
Probable ATP-dependent RNA helicase DDX41

1

16

High-throughput

0.445

High

225345

AKP8L
A-kinase anchor protein 8-like

1

6

High-throughput

0.445

High

225234

CD123
Translation initiation factor eIF2 assembly protein

1

4

High-throughput

0.437

High

225240

NTRK1
High affinity nerve growth factor receptor

1

9

High-throughput

0.437

High

225246

ARAF
Serine/threonine-protein kinase A-Raf

1

13

High-throughput

0.437

High

225256

METK2
S-adenosylmethionine synthase isoform type-2

1

2

High-throughput

0.437

High

225275

ACTC
Actin, alpha cardiac muscle 1

1

7

High-throughput

0.437

High

225303

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.437

High

225304

CE128
Centrosomal protein of 128 kDa

1

10

High-throughput

0.437

High

225312

RHG24
Rho GTPase-activating protein 24

1

3

High-throughput

0.437

High

225316

TIP
T-cell immunomodulatory protein

1

6

High-throughput

0.437

High

225325

RN185
E3 ubiquitin-protein ligase RNF185

1

11

Small-scale

0.437

High

225328

SNX27
Sorting nexin-27

1

5

High-throughput

0.437

High

213011

CP110
Centriolar coiled-coil protein of 110 kDa

1

4

Small-scale

0.417

High

62422

S35F4
Solute carrier family 35 member F4

1

1

High-throughput

0.407

High

225326

S45A3
Solute carrier family 45 member 3

1

1

High-throughput

0.407

High

225333

FEZ1
Fasciculation and elongation protein zeta-1

1

0

High-throughput

0.282

High

225296

UT2
Urea transporter 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025