HitPredict

Interactor 1: FBLN4 (O95967)
EGF-containing fibulin-like extracellular matrix protein 2 (Fibulin-4) (FIBL-4) (Protein UPH1)
Gene: EFEMP2

Interactor 2: ELN (P15502)
Elastin (Tropoelastin)
Gene: ELN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	19570982
Identification Methods	surface plasmon resonance, enzyme linked immunosorbent assay
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005201 - extracellular matrix structural constituent GO:0005576 - extracellular region GO:0031012 - extracellular matrix GO:0062023 - collagen-containing extracellular matrix GO:0071953 - elastic fiber
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 443 Hs			1 786
+	Hs
		548787 FBLN5_HUMAN (32-443): 6.48e-60: 203: 49.65		ELN_HUMAN (1-786): 3.24e-43: 170: 100.00
+	Hs
		548784 FBLN2_HUMAN (45-399): 9.48e-20: 94.5: 24.68		ELN_HUMAN (1-786): 3.24e-43: 170: 100.00
+	Hs
		548778 FBLN1_HUMAN (118-396): 4.7e-19: 91.8: 23.96		ELN_HUMAN (1-786): 3.24e-43: 170: 100.00
+	Hs
		548781 FBN1_HUMAN (34-231): 7.99e-11: 66.6: 23.31		ELN_HUMAN (1-786): 3.24e-43: 170: 100.00
+	Hs
		548782 FBN2_HUMAN (34-231): 4.81e-10: 64.3: 22.98		ELN_HUMAN (1-786): 3.24e-43: 170: 100.00
+	Hs
		804242 NOTC1_HUMAN (5-404): 6.78e-21: 98: 15.39		CO4A6_HUMAN (255-783): 1.12e-30: 132: 16.85
+	Hs
		126331 MATN2_HUMAN (161-399): 1.08e-27: 118: 22.71		CO1A1_HUMAN (1-458): 2.46e-20: 99.1: 17.73
+	Dm
		114000 CUBN_DROME (4-245): 4.55e-28: 119: 17.35		M9PB30_DROME (206-645): 2.56e-15: 83.1: 14.29
+	Hs
		596152 TENA_HUMAN (236-413): 2.65e-12: 71.4: 9.52		CO5A1_HUMAN (381-786): 5.16e-12: 72.1: 15.53