HitPredict

Interactor 1: TOP3B (O95985)
DNA topoisomerase 3-beta-1 (EC 5.6.2.1) (DNA topoisomerase III beta-1)
Gene: TOP3B

Interactor 2: FXR2 (P51116)
RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2)
Gene: FXR2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	29395067, 34709727
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 862 Hs			1 673
+	Mm
		1142924 TOP3B_MOUSE (1-862): 0: 1247: 95.59		FXR1_MOUSE (14-673): 0: 981: 62.83
+	Hs
		328776 TOP3B_HUMAN (1-862): 0: 1242: 100.00		FXR1_HUMAN (14-673): 0: 798: 51.34
+	Mm
		1207117 TOP3B_MOUSE (1-862): 0: 1247: 95.59		Q8BPK8_MOUSE (14-344): 0: 621: 71.90
+	Dm
		332125 TOP3B_DROME (1-822): 0: 1045: 58.32		FMR1_DROME (14-642): 0: 599: 34.58
+	Mm
		729615 TOP3B_MOUSE (1-862): 0: 1247: 95.59		FMR1_MOUSE (229-475): 4.6e-46: 174: 34.20
+	Hs
		328820 TOP3B_HUMAN (1-862): 0: 1242: 100.00		FMR1_HUMAN (310-475): 6.11e-45: 172: 41.42