Protein: UNC5B
Netrin receptor UNC5B (Protein unc-5 homolog 2) (Protein unc-5 homolog B) (p53-regulated receptor for death and life protein 1) (p53RDL1)

Gene: UNC5B
Organism: Homo sapiens
Interactions: 84
UniProt ID: Q8IZJ1

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0005042 - netrin receptor activity
GO:0005886 - plasma membrane
GO:0006915 - apoptotic process
GO:0033564 - anterior/posterior axon guidance

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

920475

DAPK1
Death-associated protein kinase 1

2

7

Small-scale

0.757

High

340707

NET1
Netrin-1

2

10

Small-scale

0.754

High

1316526

ALK
ALK tyrosine kinase receptor

2

20

High-throughput

0.754

High

1316513

LRIQ1
Leucine-rich repeat- and IQ domain-containing protein 1

2

4

High-throughput

0.726

High

1316522

FLRT3
Leucine-rich repeat transmembrane protein FLRT3

1

20

Small-scale

0.647

High

181803

EPHB6
Ephrin type-B receptor 6

1

15

High-throughput

0.618

High

412239

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

439783

INSR
Insulin receptor

1

20

High-throughput

0.618

High

541584

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.618

High

648586

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.618

High

710355

EPHA2
Ephrin type-A receptor 2

1

19

High-throughput

0.618

High

710730

EPHA8
Ephrin type-A receptor 8

1

18

High-throughput

0.618

High

710861

EPHB2
Ephrin type-B receptor 2

1

15

High-throughput

0.618

High

777720

VGFR3
Vascular endothelial growth factor receptor 3

1

12

High-throughput

0.618

High

931868

EPHA5
Ephrin type-A receptor 5

1

19

High-throughput

0.618

High

932098

EPHA4
Ephrin type-A receptor 4

1

16

High-throughput

0.618

High

1034175

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

20

High-throughput

0.618

High

1034290

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.618

High

1147372

EPHA7
Ephrin type-A receptor 7

1

13

High-throughput

0.618

High

1156992

NTRK3
NT-3 growth factor receptor

1

20

High-throughput

0.618

High

1316511

NEO1
Neogenin

1

7

Small-scale

0.618

High

1316521

TREM2
Triggering receptor expressed on myeloid cells 2

1

0

Small-scale

0.614

High

375705

RASK
GTPase KRas

2

15

High-throughput

0.584

High

540554

LAMP1
Lysosome-associated membrane glycoprotein 1

2

0

High-throughput

0.559

High

718146

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

2

Small-scale

0.552

High

648783

KCNA4
Potassium voltage-gated channel subfamily A member 4

1

2

High-throughput

0.515

High

943526

G6PT2
Glucose-6-phosphate exchanger SLC37A1

1

1

High-throughput

0.514

High

1316508

G6PT3
Glucose-6-phosphate exchanger SLC37A2

1

1

High-throughput

0.514

High

1316514

MF14A
Hippocampus abundant transcript 1 protein

1

1

High-throughput

0.514

High

1316506

RN149
E3 ubiquitin-protein ligase RNF149

1

1

High-throughput

0.489

High

1316525

FBX2
F-box only protein 2

1

5

High-throughput

0.489

High

189694

STX7
Syntaxin-7

1

4

High-throughput

0.479

High

218442

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.479

High

226122

STX6
Syntaxin-6

1

3

High-throughput

0.479

High

299281

FLOT1
Flotillin-1

1

2

High-throughput

0.479

High

374043

RASN
GTPase NRas

1

16

High-throughput

0.479

High

374746

RASH
GTPase HRas

1

13

High-throughput

0.479

High

463641

LYN
Tyrosine-protein kinase Lyn

1

7

High-throughput

0.479

High

464006

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

High-throughput

0.479

High

465575

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.479

High

601366

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

604088

CXA1
Gap junction alpha-1 protein

1

14

High-throughput

0.479

High

614708

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

5

High-throughput

0.479

High

631336

RAB5A
Ras-related protein Rab-5A

1

5

High-throughput

0.479

High

642965

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

2

High-throughput

0.479

High

715669

MARCS
Myristoylated alanine-rich C-kinase substrate

1

2

High-throughput

0.479

High

910126

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

953555

RAC3
Ras-related C3 botulinum toxin substrate 3

1

15

High-throughput

0.479

High

955364

CDC42
Cell division control protein 42 homolog

1

17

High-throughput

0.479

High

962255

RHOA
Transforming protein RhoA

1

17

High-throughput

0.479

High

962785

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

975119

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.479

High

978151

RHOB
Rho-related GTP-binding protein RhoB

1

19

High-throughput

0.479

High

988516

RAC1
Ras-related C3 botulinum toxin substrate 1

1

15

High-throughput

0.479

High

994294

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

1

Small-scale

0.479

High

1041166

CAV1
Caveolin-1

1

6

High-throughput

0.479

High

1087183

STX4
Syntaxin-4

1

4

High-throughput

0.479

High

1145002

RAB35
Ras-related protein Rab-35

1

7

High-throughput

0.479

High

1151772

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

1159745

OCLN
Occludin

1

6

High-throughput

0.479

High

1233338

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.479

High

1235296

STYK1
Tyrosine-protein kinase STYK1

1

17

High-throughput

0.479

High

1270896

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

1316505

CXD3
Gap junction delta-3 protein

1

14

High-throughput

0.479

High

1316507

CIP2A
Protein CIP2A

1

1

Small-scale

0.479

High

1316509

PARD3
Partitioning defective 3 homolog

1

15

High-throughput

0.479

High

1316510

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

1316516

DNJC5
DnaJ homolog subfamily C member 5

1

1

High-throughput

0.479

High

1316517

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

1316518

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

388432

B3AT
Band 3 anion transport protein

1

1

High-throughput

0.445

High

139926

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

1

High-throughput

0.437

High

179965

BET1
BET1 homolog

1

3

High-throughput

0.437

High

327351

ZFPL1
Zinc finger protein-like 1

1

1

High-throughput

0.437

High

655862

TBG1
Tubulin gamma-1 chain

1

8

High-throughput

0.437

High

698868

CALX
Calnexin

1

5

High-throughput

0.437

High

1276209

ATG9A
Autophagy-related protein 9A

1

1

High-throughput

0.437

High

1293064

TMM17
Transmembrane protein 17

1

1

High-throughput

0.437

High

1316512

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.437

High

1316515

FMNL2
Formin-like protein 2

1

1

High-throughput

0.437

High

1316524

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

3

High-throughput

0.437

High

1316519

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1316520

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.249

Low

1316523

TM216
Transmembrane protein 216

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025