HitPredict

Interactor 1: PAK4 (O96013)
Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4)
Gene: PAK4

Interactor 2: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	11756552, 31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PBD~Ras, Pkinase~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0016477 - cell migration GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 591 Hs			1 192
+	Hs
		330841 PAK4_HUMAN (1-591): 0: 586: 100.00		RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67
+	Hs
		330835 PAK4_HUMAN (1-591): 0: 586: 100.00		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		331085 PAK4_HUMAN (1-591): 0: 586: 100.00		RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64
+	Hs
		330930 PAK4_HUMAN (1-591): 0: 586: 100.00		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19
+	Hs
		330976 PAK4_HUMAN (1-591): 0: 586: 100.00		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		330933 PAK4_HUMAN (1-591): 0: 586: 100.00		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		925648 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		1330933 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64
+	Hs
		894474 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Dm
		776946 PAKM_DROME (1-589): 9.31e-163: 480: 48.82		CDC42_DROME (1-192): 2.41e-77: 231: 70.83
+	Dm
		776915 PAK_DROME (8-589): 9.88e-153: 457: 34.09		RAC1_DROME (1-192): 8.65e-83: 245: 91.67
+	Dm
		1177643 PAK_DROME (8-589): 9.88e-153: 457: 34.09		Q7JWS8_DROME (2-192): 5.45e-82: 243: 71.20
+	Dm
		819751 PAK_DROME (8-589): 9.88e-153: 457: 34.09		RAC2_DROME (1-192): 2.18e-81: 241: 89.58
+	Dm
		776941 PAK_DROME (8-589): 9.88e-153: 457: 34.09		CDC42_DROME (1-192): 2.41e-77: 231: 70.83
+	Sc
		580325 CLA4_YEAST (1-586): 6.09e-144: 439: 25.83		CDC42_YEAST (1-192): 9.68e-77: 229: 68.75
+	Sc
		580329 STE20_YEAST (11-591): 6.96e-143: 439: 31.62		CDC42_YEAST (1-192): 9.68e-77: 229: 68.75
+	Dm
		776912 Q9VEV1_DROME (2-589): 7.2e-141: 422: 28.74		RAC1_DROME (1-192): 8.65e-83: 245: 91.67
+	Dm
		819750 Q9VEV1_DROME (2-589): 7.2e-141: 422: 28.74		RAC2_DROME (1-192): 2.18e-81: 241: 89.58
+	Dm
		776940 Q9VEV1_DROME (2-589): 7.2e-141: 422: 28.74		CDC42_DROME (1-192): 2.41e-77: 231: 70.83
+	Sc
		580338 SKM1_YEAST (1-586): 4.32e-139: 420: 25.82		CDC42_YEAST (1-192): 9.68e-77: 229: 68.75