Protein: ITPR1
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Inositol 1,4,5 trisphosphate receptor) (Inositol 1,4,5-trisphosphate receptor type 1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor)

Gene: ITPR1
Organism: Homo sapiens
Interactions: 132
UniProt ID: Q14643

Gene Ontology (top 5):
GO:0000902 - cell morphogenesis
GO:0001666 - response to hypoxia
GO:0005220 - inositol 1,4,5-trisphosphate-gated calcium channel activity
GO:0005509 - calcium ion binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1129050

CABP1
Calcium-binding protein 1

2

10

Small-scale

0.812

High

1119634

KGP1
cGMP-dependent protein kinase 1

2

10

Small-scale

0.799

High

986851

FKB1A
Peptidyl-prolyl cis-trans isomerase FKBP1A

2

9

Small-scale

0.757

High

1129052

TRPC4
Short transient receptor potential channel 4

2

14

Small-scale

0.757

High

692697

CALL3
Calmodulin-like protein 3

1

4

High-throughput

0.691

High

1128397

ITPR3
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3

1

14

High-throughput

0.691

High

1129007

RASEF
Ras and EF-hand domain-containing protein

1

2

High-throughput

0.691

High

1129040

CABP2
Calcium-binding protein 2

1

10

High-throughput

0.691

High

321242

ERLN2
Erlin-2

4

5

Small-scale

0.676

High

60629

TESP1
Protein TESPA1

3

2

High-throughput

0.667

High

764228

CAH8
Carbonic anhydrase-related protein

4

2

Small-scale

0.638

High

522097

BCL2
Apoptosis regulator Bcl-2

2

5

Small-scale

0.634

High

170505

RAB7L
Ras-related protein Rab-7L1

2

6

High-throughput

0.628

High

962050

RHOA
Transforming protein RhoA

2

12

Small-scale

0.624

High

1126678

BECN1
Beclin-1

2

1

Small-scale

0.624

High

878231

TRPC1
Short transient receptor potential channel 1

1

13

Small-scale

0.618

High

1108490

TRPC3
Short transient receptor potential channel 3

1

13

Small-scale

0.618

High

1125431

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

11

High-throughput

0.618

High

1128994

ITPR1
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1

1

14

Small-scale

0.618

High

1129025

CHP1
Calcineurin B homologous protein 1

1

2

High-throughput

0.618

High

1129054

TRPC5
Short transient receptor potential channel 5

1

13

Small-scale

0.618

High

1129055

TRPC6
Short transient receptor potential channel 6

1

14

Small-scale

0.618

High

1129060

IRAG1
Inositol 1,4,5-triphosphate receptor associated 1

2

3

Small-scale

0.611

High

230024

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

2

0

Small-scale

0.602

High

1110442

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

2

11

High-throughput

0.601

High

728237

AKT1
RAC-alpha serine/threonine-protein kinase

1

7

Small-scale

0.586

High

283245

ERLN1
Erlin-1

2

4

Small-scale

0.584

High

1129021

RN170
E3 ubiquitin-protein ligase RNF170

2

2

Small-scale

0.584

High

410848

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

1

High-throughput

0.576

High

1129009

FXL14
F-box/LRR-repeat protein 14

2

1

High-throughput

0.574

High

1129023

TAFA4
Chemokine-like protein TAFA-4

2

2

High-throughput

0.574

High

1129039

B2L10
Bcl-2-like protein 10

1

2

Small-scale

0.569

High

799115

BRCA1
Breast cancer type 1 susceptibility protein

1

0

Small-scale

0.554

High

287697

KS6A5
Ribosomal protein S6 kinase alpha-5

1

7

High-throughput

0.536

High

698658

CALX
Calnexin

1

2

High-throughput

0.536

High

866684

CAZA2
F-actin-capping protein subunit alpha-2

1

2

High-throughput

0.536

High

1052016

CALD1
Caldesmon

1

12

High-throughput

0.536

High

1110340

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

11

High-throughput

0.536

High

1120436

SCRB2
Lysosome membrane protein 2

1

1

High-throughput

0.536

High

1129010

SYNPO
Synaptopodin

1

3

High-throughput

0.536

High

1129049

PLK2
Serine/threonine-protein kinase PLK2

1

5

High-throughput

0.536

High

1129035

E41L1
Band 4.1-like protein 1

1

0

Small-scale

0.529

High

1128998

PLEC
Plectin

1

5

High-throughput

0.515

High

1129003

TF2H5
General transcription factor IIH subunit 5

1

0

High-throughput

0.513

High

1129020

VMP1
Vacuole membrane protein 1

1

0

High-throughput

0.513

High

1051927

KPCD
Protein kinase C delta type

1

3

Small-scale

0.501

High

298265

BODG
Gamma-butyrobetaine dioxygenase

1

2

High-throughput

0.489

High

629868

BTF3
Transcription factor BTF3

1

2

High-throughput

0.489

High

848624

MAGA9
Melanoma-associated antigen 9

1

2

High-throughput

0.489

High

1125325

FGL2
Fibroleukin

1

4

High-throughput

0.489

High

1129019

SGF29
SAGA-associated factor 29

1

2

High-throughput

0.489

High

1129059

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

3

High-throughput

0.489

High

1129057

STA13
StAR-related lipid transfer protein 13

1

0

Small-scale

0.486

High

173917

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

6

High-throughput

0.479

High

218182

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

291333

NU155
Nuclear pore complex protein Nup155

1

2

High-throughput

0.479

High

330967

KI20A
Kinesin-like protein KIF20A

1

6

High-throughput

0.479

High

337945

CNEP1
CTD nuclear envelope phosphatase 1

1

3

High-throughput

0.479

High

417434

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

2

High-throughput

0.479

High

418131

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

2

High-throughput

0.479

High

445880

ENOA
Alpha-enolase

1

1

High-throughput

0.479

High

466253

RHOC
Rho-related GTP-binding protein RhoC

1

11

High-throughput

0.479

High

581050

RAC2
Ras-related C3 botulinum toxin substrate 2

1

11

High-throughput

0.479

High

605684

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

9

High-throughput

0.479

High

824146

RL13A
Large ribosomal subunit protein uL13

1

1

High-throughput

0.479

High

847531

SSRA
Translocon-associated protein subunit alpha

1

2

High-throughput

0.479

High

867135

CAPZB
F-actin-capping protein subunit beta

1

2

High-throughput

0.479

High

894748

EMD
Emerin

1

2

High-throughput

0.479

High

901241

RAB7A
Ras-related protein Rab-7a

1

7

High-throughput

0.479

High

903908

BAP31
B-cell receptor-associated protein 31

1

3

High-throughput

0.479

High

910052

RND2
Rho-related GTP-binding protein RhoN

1

12

High-throughput

0.479

High

934613

TERA
Transitional endoplasmic reticulum ATPase

1

5

Small-scale

0.479

High

951149

SC61B
Protein transport protein Sec61 subunit beta

1

2

High-throughput

0.479

High

953449

RAC3
Ras-related C3 botulinum toxin substrate 3

1

11

High-throughput

0.479

High

955173

CDC42
Cell division control protein 42 homolog

1

11

High-throughput

0.479

High

1015442

RHOG
Rho-related GTP-binding protein RhoG

1

11

High-throughput

0.479

High

1128997

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

1128999

CRTC2
CREB-regulated transcription coactivator 2

1

2

Small-scale

0.479

High

1129004

TM11B
Transmembrane protease serine 11B

1

3

High-throughput

0.479

High

1129008

CXD3
Gap junction delta-3 protein

1

5

High-throughput

0.479

High

1129011

SIR6
NAD-dependent protein deacylase sirtuin-6

1

3

High-throughput

0.479

High

1129013

DHB11
Estradiol 17-beta-dehydrogenase 11

1

2

High-throughput

0.479

High

1129022

DNJC1
DnaJ homolog subfamily C member 1

1

8

High-throughput

0.479

High

1129024

SEC62
Translocation protein SEC62

1

2

High-throughput

0.479

High

1129026

ERP44
Endoplasmic reticulum resident protein 44

1

1

Small-scale

0.479

High

1129028

DERL1
Derlin-1

1

2

High-throughput

0.479

High

1129029

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

1129031

LNP
Endoplasmic reticulum junction formation protein lunapark

1

3

High-throughput

0.479

High

1129032

DJC25
DnaJ homolog subfamily C member 25

1

6

High-throughput

0.479

High

1129033

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

2

High-throughput

0.479

High

1129034

CHM4B
Charged multivesicular body protein 4b

1

2

High-throughput

0.479

High

1129036

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.479

High

1129037

TMT1A
Thiol S-methyltransferase TMT1A

1

2

High-throughput

0.479

High

1129038

ECT2
Protein ECT2

1

1

High-throughput

0.479

High

1129043

PXMP2
Peroxisomal membrane protein 2

1

2

High-throughput

0.479

High

1129044

ST7
Suppressor of tumorigenicity 7 protein

1

2

High-throughput

0.479

High

1129046

TMPS4
Transmembrane protease serine 4

1

3

High-throughput

0.479

High

1129048

ELOV5
Very long chain fatty acid elongase 5

1

2

High-throughput

0.479

High

1129051

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

2

High-throughput

0.479

High

1129056

DJC16
DnaJ homolog subfamily C member 16

1

4

High-throughput

0.479

High

220374

LAT
Linker for activation of T-cells family member 1

1

0

Small-scale

0.458

High

702955

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.458

High

760443

SDC2
Syndecan-2

1

0

Small-scale

0.458

High

1097981

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

0

Small-scale

0.458

High

1129014

BANK1
B-cell scaffold protein with ankyrin repeats

1

0

Small-scale

0.458

High

1129053

AMFR
E3 ubiquitin-protein ligase AMFR

1

0

Small-scale

0.458

High

303017

PDE5A
cGMP-specific 3',5'-cyclic phosphodiesterase

1

3

Small-scale

0.457

High

351220

MOT3
Monocarboxylate transporter 3

1

3

High-throughput

0.445

High

704010

5HT1E
5-hydroxytryptamine receptor 1E

1

1

High-throughput

0.445

High

1103167

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.445

High

1128995

MFS10
Major facilitator superfamily domain-containing protein 10

1

2

High-throughput

0.445

High

1129001

MFSD5
Molybdate-anion transporter

1

2

High-throughput

0.445

High

1129002

NPAL3
NIPA-like protein 3

1

2

High-throughput

0.445

High

1129006

S35F3
Solute carrier family 35 member F3

1

2

High-throughput

0.445

High

1129015

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

6

High-throughput

0.445

High

1129045

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

768193

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

1128996

TNIP1
TNFAIP3-interacting protein 1

1

9

High-throughput

0.437

High

1129000

A16L1
Autophagy-related protein 16-1

1

8

High-throughput

0.437

High

1129017

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

1

2

Small-scale

0.437

High

1129027

CNPY3
Protein canopy homolog 3

1

1

Small-scale

0.437

High

1129042

ANLN
Anillin

1

2

High-throughput

0.437

High

1129047

OTULL
Inactive ubiquitin thioesterase OTULINL

1

2

High-throughput

0.437

High

1129016

CTL1
Choline transporter-like protein 1

1

0

High-throughput

0.426

High

1129030

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

1129005

S15A3
Solute carrier family 15 member 3

1

3

High-throughput

0.407

High

1129012

FRMD1
FERM domain-containing protein 1

1

2

High-throughput

0.407

High

1129041

S35C2
Solute carrier family 35 member C2

1

2

High-throughput

0.407

High

105935

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

1129018

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.249

Low

1129058

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025