Protein: ITPR2
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 (IP3 receptor isoform 2) (IP3R 2) (InsP3R2) (Inositol 1,4,5-trisphosphate receptor type 2) (Type 2 inositol 1,4,5-trisphosphate receptor) (Type 2 InsP3 receptor)

Gene: ITPR2
Organism: Homo sapiens
Interactions: 130
UniProt ID: Q14571

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0005220 - inositol 1,4,5-trisphosphate-gated calcium channel activity
GO:0005509 - calcium ion binding
GO:0005524 - ATP binding
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1128387

TRPC4
Short transient receptor potential channel 4

1

14

Small-scale

0.713

High

387112

TNNC2
Troponin C, skeletal muscle

1

7

High-throughput

0.691

High

1128331

ITPR3
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3

1

14

High-throughput

0.691

High

1128345

RASEF
Ras and EF-hand domain-containing protein

1

2

High-throughput

0.691

High

1128377

CABP2
Calcium-binding protein 2

1

10

High-throughput

0.691

High

60627

TESP1
Protein TESPA1

3

2

High-throughput

0.667

High

1128371

P2Y12
P2Y purinoceptor 12

3

4

High-throughput

0.667

High

1047007

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

4

0

High-throughput

0.653

High

1128395

CCG2
Voltage-dependent calcium channel gamma-2 subunit

3

0

High-throughput

0.638

High

170503

RAB7L
Ras-related protein Rab-7L1

2

6

High-throughput

0.628

High

733696

ACHA3
Neuronal acetylcholine receptor subunit alpha-3

2

1

High-throughput

0.628

High

1128354

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

2

1

High-throughput

0.628

High

1125429

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

11

High-throughput

0.618

High

1128355

LPAR1
Lysophosphatidic acid receptor 1

2

3

High-throughput

0.611

High

298263

BODG
Gamma-butyrobetaine dioxygenase

3

2

High-throughput

0.609

High

764227

CAH8
Carbonic anhydrase-related protein

3

2

High-throughput

0.609

High

1128375

IPPK
Inositol-pentakisphosphate 2-kinase

2

0

High-throughput

0.602

High

1110440

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

2

11

High-throughput

0.601

High

417432

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

2

2

High-throughput

0.584

High

1128379

ANLN
Anillin

2

2

High-throughput

0.584

High

516516

CALM3
Calmodulin-3

1

4

High-throughput

0.575

High

1128357

LMBL2
Lethal(3)malignant brain tumor-like protein 2

2

1

High-throughput

0.574

High

1128362

TAFA4
Chemokine-like protein TAFA-4

2

2

High-throughput

0.574

High

842372

RL35
Large ribosomal subunit protein uL29

2

0

High-throughput

0.559

High

1128335

RN123
E3 ubiquitin-protein ligase RNF123

1

9

High-throughput

0.553

High

1128340

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.553

High

248703

PEPL
Periplakin

1

9

High-throughput

0.536

High

640387

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

2

High-throughput

0.536

High

772801

MYH9
Myosin-9

1

5

High-throughput

0.536

High

866682

CAZA2
F-actin-capping protein subunit alpha-2

1

2

High-throughput

0.536

High

907012

CCR6
C-C chemokine receptor type 6

1

3

High-throughput

0.536

High

1052014

CALD1
Caldesmon

1

12

High-throughput

0.536

High

1101486

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

3

High-throughput

0.536

High

1110241

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

11

High-throughput

0.536

High

1110338

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

11

High-throughput

0.536

High

1128334

TTMP
TPA-induced transmembrane protein

1

1

High-throughput

0.536

High

1128390

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

11

High-throughput

0.536

High

1128396

IRAG1
Inositol 1,4,5-triphosphate receptor associated 1

1

3

High-throughput

0.536

High

1128388

ZRAN1
Ubiquitin thioesterase ZRANB1

2

1

High-throughput

0.533

High

1128343

S15A3
Solute carrier family 15 member 3

2

3

High-throughput

0.521

High

945227

NU107
Nuclear pore complex protein Nup107

1

0

High-throughput

0.513

High

1128341

TPRA1
Transmembrane protein adipocyte-associated 1

1

0

High-throughput

0.513

High

1128369

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.513

High

765512

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.489

High

848622

MAGA9
Melanoma-associated antigen 9

1

2

High-throughput

0.489

High

1128360

SGF29
SAGA-associated factor 29

1

2

High-throughput

0.489

High

173915

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

6

High-throughput

0.479

High

218181

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

241684

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

251758

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

15

High-throughput

0.479

High

291331

NU155
Nuclear pore complex protein Nup155

1

2

High-throughput

0.479

High

330965

KI20A
Kinesin-like protein KIF20A

1

6

High-throughput

0.479

High

332999

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

1

High-throughput

0.479

High

337943

CNEP1
CTD nuclear envelope phosphatase 1

1

3

High-throughput

0.479

High

418129

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

2

High-throughput

0.479

High

548333

CP2C9
Cytochrome P450 2C9

1

1

High-throughput

0.479

High

603979

CXA1
Gap junction alpha-1 protein

1

5

High-throughput

0.479

High

605681

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

9

High-throughput

0.479

High

610328

PRS6A
26S proteasome regulatory subunit 6A

1

6

High-throughput

0.479

High

847529

SSRA
Translocon-associated protein subunit alpha

1

2

High-throughput

0.479

High

867133

CAPZB
F-actin-capping protein subunit beta

1

2

High-throughput

0.479

High

880547

LMAN1
Protein ERGIC-53

1

1

High-throughput

0.479

High

894746

EMD
Emerin

1

2

High-throughput

0.479

High

901238

RAB7A
Ras-related protein Rab-7a

1

7

High-throughput

0.479

High

901809

RAB9A
Ras-related protein Rab-9A

1

6

High-throughput

0.479

High

903906

BAP31
B-cell receptor-associated protein 31

1

3

High-throughput

0.479

High

951147

SC61B
Protein transport protein Sec61 subunit beta

1

2

High-throughput

0.479

High

955169

CDC42
Cell division control protein 42 homolog

1

11

High-throughput

0.479

High

962046

RHOA
Transforming protein RhoA

1

12

High-throughput

0.479

High

1016010

RL19
Large ribosomal subunit protein eL19

1

1

High-throughput

0.479

High

1027000

REEP5
Receptor expression-enhancing protein 5

1

1

High-throughput

0.479

High

1035615

KIF23
Kinesin-like protein KIF23

1

3

High-throughput

0.479

High

1128333

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

1128346

CXD3
Gap junction delta-3 protein

1

5

High-throughput

0.479

High

1128349

PDZD8
PDZ domain-containing protein 8

1

1

High-throughput

0.479

High

1128356

ESR2
Estrogen receptor beta

1

6

High-throughput

0.479

High

1128358

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

2

High-throughput

0.479

High

1128361

DNJC1
DnaJ homolog subfamily C member 1

1

8

High-throughput

0.479

High

1128363

SEC62
Translocation protein SEC62

1

2

High-throughput

0.479

High

1128366

DERL1
Derlin-1

1

2

High-throughput

0.479

High

1128367

LNP
Endoplasmic reticulum junction formation protein lunapark

1

3

High-throughput

0.479

High

1128368

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.479

High

1128370

DJC25
DnaJ homolog subfamily C member 25

1

6

High-throughput

0.479

High

1128372

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

2

High-throughput

0.479

High

1128373

TMT1A
Thiol S-methyltransferase TMT1A

1

2

High-throughput

0.479

High

1128374

ECT2
Protein ECT2

1

1

High-throughput

0.479

High

1128376

B2L10
Bcl-2-like protein 10

1

2

Small-scale

0.479

High

1128380

PXMP2
Peroxisomal membrane protein 2

1

2

High-throughput

0.479

High

1128381

ST7
Suppressor of tumorigenicity 7 protein

1

2

High-throughput

0.479

High

1128385

ELOV5
Very long chain fatty acid elongase 5

1

2

High-throughput

0.479

High

1128386

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

2

High-throughput

0.479

High

1128391

LAMP3
Lysosome-associated membrane glycoprotein 3

1

2

High-throughput

0.479

High

1128392

DJC16
DnaJ homolog subfamily C member 16

1

4

High-throughput

0.479

High

124345

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.458

High

223040

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

342872

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.458

High

714118

PML
Protein PML

1

0

High-throughput

0.458

High

715062

OAS2
2'-5'-oligoadenylate synthase 2

1

0

Small-scale

0.458

High

967435

RS7
Small ribosomal subunit protein eS7

1

0

High-throughput

0.458

High

104149

F5H1C8
Solute carrier family 15 member 3

1

3

High-throughput

0.445

High

190226

MOT4
Monocarboxylate transporter 4

1

3

High-throughput

0.445

High

351218

MOT3
Monocarboxylate transporter 3

1

3

High-throughput

0.445

High

1128332

MFS10
Major facilitator superfamily domain-containing protein 10

1

2

High-throughput

0.445

High

1128337

MFSD5
Molybdate-anion transporter

1

2

High-throughput

0.445

High

1128339

NPAL3
NIPA-like protein 3

1

2

High-throughput

0.445

High

1128344

S35F3
Solute carrier family 35 member F3

1

2

High-throughput

0.445

High

1128350

ZNT7
Zinc transporter 7

1

4

High-throughput

0.445

High

1128351

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

4

High-throughput

0.445

High

1128352

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

6

High-throughput

0.445

High

1128353

S35F5
Solute carrier family 35 member F5

1

5

High-throughput

0.445

High

1128364

S1PR3
Sphingosine 1-phosphate receptor 3

1

3

High-throughput

0.445

High

1128393

S27A5
Long-chain fatty acid transport protein 5

1

2

High-throughput

0.445

High

1128383

EXOC1
Exocyst complex component 1

1

0

High-throughput

0.438

High

611120

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

1

High-throughput

0.437

High

629865

BTF3
Transcription factor BTF3

1

2

High-throughput

0.437

High

872321

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.437

High

976270

RB11A
Ras-related protein Rab-11A

1

1

High-throughput

0.437

High

1128336

A16L1
Autophagy-related protein 16-1

1

8

High-throughput

0.437

High

1128342

DYR2
Dihydrofolate reductase 2, mitochondrial

1

1

High-throughput

0.437

High

1128347

SIR6
NAD-dependent protein deacylase sirtuin-6

1

3

High-throughput

0.437

High

1128348

DHB11
Estradiol 17-beta-dehydrogenase 11

1

2

High-throughput

0.437

High

1128359

S2546
Mitochondrial outer membrane protein SLC25A46

1

1

High-throughput

0.437

High

1128365

CNPY3
Protein canopy homolog 3

1

1

Small-scale

0.437

High

1128382

OTULL
Inactive ubiquitin thioesterase OTULINL

1

2

High-throughput

0.437

High

1128338

ZNT6
Zinc transporter 6

1

4

High-throughput

0.407

High

1128378

S35C2
Solute carrier family 35 member C2

1

2

High-throughput

0.407

High

1128389

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.269

Low

129075

MEN1
Menin

1

0

High-throughput

0.249

Low

1128394

RT07
Small ribosomal subunit protein uS7m

1

0

High-throughput

0.249

Low

1128384

LYAR
Cell growth-regulating nucleolar protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025